Indications & Uses
Spiramycin is used to treat infections of the respiratory tract, the mouth (buccal cavity), the skin and the soft tissues, when the infection is caused by susceptible organisms. It is also an alternative choice for gonorrhea caused by Neisseria gonorrhoeae in patients who are allergic to the penicillins. Before starting treatment for gonorrhea, the doctor should rule out a possible infection with T. pallidum at the same time.
Pharmacology
How macrolides work has been a matter of debate for some time. Spiramycin is a 16-membered macrolide, and it inhibits translocation by binding to the 50S subunits of bacterial ribosomes, with an apparent 1 : 1 stoichiometry. The antibiotic is a potent inhibitor of the binding of both donor and acceptor substrates to the ribosome. Its primary action comes from stimulating the dissociation of peptidyl-tRNA from the ribosomes during translocation.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For adults, Spiramycin is given at 6 to 9 Million International Units in 24 hours, split into 2 doses. In severe infections the daily dose may go up to 12 to 15 Million International Units. For gonorrhea, the dose is 12 to 13.5 Million International Units taken as a single dose.
For children, the usual daily dose is based on 150,000 I.U./kg body weight, given in 2 or 3 divided doses.
Side Effects
Spiramycin can cause nausea, vomiting and diarrhea. Some people also get inflamed bowels, pruritus (itchy skin), or tingling or numbness in the skin.
Cautions & Contraindications
Warnings & Precautions
Spiramycin, like any antibiotic, should be given with care to a patient who has shown any kind of allergy, especially an allergy to drugs. If the treatment goes on for a long time or is repeated, watch for superinfection, which happens when organisms that the antibiotic doesn't affect overgrow. If superinfection does occur, stop the medicine and take suitable measures.
Contraindications
Spiramycin must not be given to anyone who is known to be hypersensitive to the medicine. It also must not be used in patients with meningitis. The reason is that spiramycin reaches the cerebrospinal fluid at levels much lower than those in the blood, and these levels are too low to be clinically useful.
Pregnancy & Breastfeeding
Nobody has yet established whether Spiramycin is safe to use during pregnancy.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
No case of accidental overdosage with Spiramycin has been reported. When oral doses go above 4 gm per day, a person may get abdominal discomfort, nausea or diarrhea. No specific treatment has been proposed, so management should be symptomatic.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Spiramycin in a dry place, between 15ºC and 30ºC.
Drug Interactions
Common questions about Rovamycine
What is Rovamycine Tablet?
Rovamycine Tablet is a medicine that contains Spiramycin. It is made by Synovia Pharma PLC. It belongs to the Macrolides group of medicines.
What is Rovamycine used for?
Spiramycin is used to treat infections of the respiratory tract, the mouth (buccal cavity), the skin and the soft tissues, when the infection is caused by susceptible organisms. It is also an alternative choice for gonorrhea caused by Neisseria gonorrhoeae in patients who are allergic to the penicillins.
What are the side effects of Rovamycine?
Spiramycin can cause nausea, vomiting and diarrhea. Some people also get inflamed bowels, pruritus (itchy skin), or tingling or numbness in the skin.
Can I take Rovamycine during pregnancy or while breastfeeding?
Nobody has yet established whether Spiramycin is safe to use during pregnancy. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Rovamycine?
No case of accidental overdosage with Spiramycin has been reported. When oral doses go above 4 gm per day, a person may get abdominal discomfort, nausea or diarrhea. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Rovamycine?
Keep Spiramycin in a dry place, between 15ºC and 30ºC.
Can I take other medicines with Rovamycine?
Some medicines can interact with Spiramycin, for example: Levodopa. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Rovamycine?
Rovamycine is a prescription (Rx) medicine. Take it as your doctor advises.