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Other brands with the same active ingredient
These brands contain the same active ingredient (Rasagiline). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Ralcet 1 is indicated for:
Pharmacology
Rasagiline is an irreversible inhibitor of monoamine oxidase. Doctors use it on its own in early Parkinson's disease, or as an add-on treatment in more advanced cases. It works through its MAO-B inhibitory activity, which raises the extracellular level of dopamine in the striatum. This higher dopamine level and the increased dopaminergic activity that follows are likely to be behind the benefit seen with rasagiline in models of dopaminergic motor dysfunction.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended dose of Rasagiline is 1 mg by mouth once daily, either on its own or as an add-on in patients who are not taking levodopa. For patients taking levodopa, with or without other PD drugs (for example a dopamine agonist, amantadine or anticholinergics), the starting dose is 0.5 mg once daily. If the patient tolerates 0.5 mg a day but the clinical response is not sufficient, the dose may be increased to 1 mg once daily. When Rasagiline is given together with levodopa, the levodopa dose may be reduced, depending on how the individual patient responds. The recommended dose should not be exceeded because of the risk of hypertension.
Pediatric use: Safety and effectiveness in children have not been established.
Geriatric use: No significant differences in the safety profile were seen between elderly and non-elderly patients.
Side Effects
Rasagiline can cause joint pain, mild headache, depressed mood, dizziness and a spinning sensation. Some people also get hair loss, a mild skin rash, or numbness or a tingly feeling. Dry mouth, loss of appetite, constipation, diarrhea, stomach pain or upset, vomiting and weight loss are other side effects that may occur, and there can be others as well.
Cautions & Contraindications
Contraindications
Rasagiline must not be used together with meperidine, tramadol, methadone or propoxyphene. It must also not be used with MAO inhibitors (MAOIs), and that includes other selective MAO-B inhibitors. The reason is the risk of serotonin syndrome.
Pregnancy & Breastfeeding
Rasagiline is in pregnancy category C, so a doctor should be careful when prescribing it to a pregnant woman. Experimental data showed that Rasagiline inhibits prolactin secretion, which means it may also inhibit lactation. Nobody knows yet whether Rasagiline passes into human milk. For that reason, take care when giving it to a breastfeeding mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
An overdose of Rasagiline may cause drowsiness, dizziness, faintness, irritability, hyperactivity, agitation, severe headache, hallucinations, trismus, opisthotonos, convulsions and coma. It may also cause a rapid and irregular pulse, hypertension, hypotension and vascular collapse. Other signs are precordial pain, respiratory depression and failure, hyperpyrexia, diaphoresis, and cool, clammy skin.
Treatment: there is no specific antidote for Rasagiline overdose, so the following suggestions are offered. Breathing should be supported with appropriate measures, including airway management, supplemental oxygen and mechanical ventilator assistance when required. Body temperature should be watched closely, and hyperpyrexia may need intensive management. Keeping fluid and electrolyte balance in order is essential. For this reason, after an overdose with Rasagiline, dietary tyramine restriction should be followed for several weeks to lower the risk of a hypertensive tyramine reaction. A poison control center should also be called for the most current treatment guidelines.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Rasagiline in a dry place at a temperature not above 30ºC, and protect it from light. Keep it out of reach of children. Shops can sell it only on the prescription of a registered physician.
Drug Interactions
Common questions about Ralcet 1 1 mg
What is Ralcet 1 1 mg Tablet?
Ralcet 1 1 mg Tablet is a medicine that contains Rasagiline. It is made by Sun Pharmaceuticals (EZ) Ltd., Narayanganj. It belongs to the Antiparkinson drugs group of medicines.
What is Ralcet 1 used for?
Ralcet 1 is used for: Parkinson's Disease.
What are the side effects of Ralcet 1?
Rasagiline can cause joint pain, mild headache, depressed mood, dizziness and a spinning sensation. Some people also get hair loss, a mild skin rash, or numbness or a tingly feeling.
Can I take Ralcet 1 during pregnancy or while breastfeeding?
Rasagiline is in pregnancy category C, so a doctor should be careful when prescribing it to a pregnant woman. Experimental data showed that Rasagiline inhibits prolactin secretion, which means it may also inhibit lactation. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Ralcet 1?
An overdose of Rasagiline may cause drowsiness, dizziness, faintness, irritability, hyperactivity, agitation, severe headache, hallucinations, trismus, opisthotonos, convulsions and coma. It may also cause a rapid and irregular pulse, hypertension, hypotension and vascular collapse. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Ralcet 1?
Keep Rasagiline in a dry place at a temperature not above 30ºC, and protect it from light. Keep it out of reach of children.
Can I take other medicines with Ralcet 1?
Some medicines can interact with Rasagiline, for example: Dextromethorphan + Phenylephrine + Triprolidine, Dextromethorphan + Pseudoephedrine + Triprolidine. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Ralcet 1?
Ralcet 1 is a prescription (Rx) medicine. Take it as your doctor advises.