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These brands contain the same active ingredient (Quetiapine Fumarate). Same strength and form. Confirm the switch with your doctor or pharmacist.
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Other strengths and forms by Opsonin Pharma Limited
Indications & Uses
Queta is indicated for:
Pharmacology
Quetiapine Fumarate is an atypical psychotropic medicine from a chemical class called the dibenzothiazepine derivatives. In the brain, quetiapine blocks several neurotransmitter receptors: serotonin 5HT1A and 5HT2, dopamine D1 and D2, histamine H1, and adrenergic α1 and α2 receptors. It has no appreciable affinity for cholinergic muscarinic and benzodiazepine receptors.
How quetiapine works is not known. It has been proposed, though, that its effect in schizophrenia comes from a combination of dopamine D2 and serotonin 5HT2 antagonism. Blocking the histamine H1 receptors may explain the somnolence seen with this medicine, and blocking the adrenergic α receptors may explain the orthostatic hypotension.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Acute and chronic psychoses, including schizophrenia: Quetiapine is given twice a day, with or without food. The total daily dose for the first four days is 50 mg on Day 1, 100 mg on Day 2, 200 mg on Day 3 and 300 mg on Day 4. From Day 4 onwards, the dose is titrated to the usual effective range of 300 to 450 mg/day. It can still be adjusted within the range of 150 to 750 mg/day, depending on the clinical response and how well the individual patient tolerates it.
Manic episodes associated with bipolar disorder: Give it twice a day, with or without food. The total daily dose for the first four days is 100 mg on Day 1, 200 mg on Day 2, 300 mg on Day 3 and 400 mg on Day 4. Further adjustments, up to 800mg/day by Day 6, should be in steps of no more than 200 mg/day. The dose can be adjusted within the range of 200 to 800 mg/day, depending on clinical response and tolerability in the individual patient. The usual effective dose is 400 to 800mg/day.
Depressive episodes associated with bipolar disorder: Give it once a day at bedtime, with or without food. The usual dose is 300 mg/day. For the first four days the daily dose is 50 mg on Day 1, 100 mg on Day 2, 200 mg on Day 3 and 300 mg on Day 4. Quetiapine can be titrated to 400 mg on Day 5 and up to 600mg by Day 8. Antidepressant efficacy was shown at 300mg and 600 mg, but the 600mg group showed no additional benefit during short term treatment.
Maintenance treatment of bipolar I disorder in combination with mood stabilizers: Patients who have responded to quetiapine together with a mood stabiliser in the acute treatment of bipolar disorder should stay on quetiapine at the same dose. The dose can be re-adjusted depending on the clinical response and tolerability of the individual patient. Efficacy was shown with quetiapine given twice daily, totalling 400mg to 800mg a day, as combination therapy with a mood stabilizer.
Side Effects
Quetiapine Fumarate most often causes somnolence, dizziness and dry mouth. People may also have withdrawal (discontinuation) symptoms, weight gain and extrapyramidal symptoms. Blood changes are common too: higher serum triglyceride levels, higher total cholesterol (mostly LDL cholesterol), lower HDL cholesterol and decreased haemoglobin. These are the Adverse Drug Reactions (ADRs) reported most commonly with quetiapine.
Cautions & Contraindications
Warnings & Precautions
Suicidal thoughts or clinical worsening: depression carries a higher risk of suicidal thoughts, self-harm and suicide (suicide-related events), and this risk stays until significant remission occurs. Concomitant illness: Quetiapine Fumarate should be used with caution in patients with known cardiovascular disease, cerebrovascular disease, or other conditions that make low blood pressure more likely. It may cause orthostatic hypotension, especially during the initial dose-titration period. Seizures: as with other antipsychotics, take care when treating patients who have a history of seizures. Tardive dyskinesia and extrapyramidal symptoms (EPS): if signs and symptoms of tardive dyskinesia appear, the doctor should consider reducing the dose or stopping Quetiapine Fumarate. Neuroleptic malignant syndrome: this syndrome has been linked with antipsychotic treatment. If it happens, the medicine should be stopped and appropriate medical treatment given. QT prolongation: as with other antipsychotics, be careful when prescribing to patients with cardiovascular disease or a family history of QT prolongation. Neutropenia: severe neutropenia (<0.5x109/L) has been reported uncommonly in clinical trials. Most cases of severe neutropenia occurred within the first two months of starting treatment. Hyperglycemia and diabetes mellitus: clinical trials have shown increases in blood glucose and hyperglycaemia, along with occasional reports of diabetes, in people taking Quetiapine Fumarate.
Contraindications
Quetiapine should not be given to anyone who is hypersensitive to it.
Pregnancy & Breastfeeding
Doctors have not established whether Quetiapine is safe or effective during human pregnancy. So it should be used in pregnancy only when the benefits justify the possible risks, and the dose and the length of treatment should be kept as low and as short as possible.
It is not known how much Quetiapine passes into human milk. Women who are breast-feeding should therefore be advised to avoid breast-feeding while they are taking Quetiapine.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Elderly: Quetiapine Fumarate should be used with caution in older people, as with other antipsychotics, and especially at the start of treatment. The dose may need to be raised more slowly, and the daily dose may need to be lower than in younger patients. This depends on how the individual patient responds and how well they tolerate the medicine. In elderly subjects, the mean plasma clearance of Quetiapine Fumarate was reduced by 30% to 50% compared with younger patients.
Children and Adolescents: Quetiapine Fumarate is not indicated for use in children and adolescents below 18 years of age.
Overdose
In clinical trials, people have survived acute overdoses of up to 30 grams of Quetiapine Fumarate. There is no specific antidote to Quetiapine Fumarate. In severe intoxication, the doctor should consider that more than one drug may be involved, and intensive care is recommended. This means establishing and maintaining a patent airway, making sure oxygenation and ventilation are adequate, and monitoring and supporting the cardiovascular system.
If refractory hypotension occurs in a Quetiapine Fumarate overdose, it should be treated with suitable measures such as intravenous fluids and/or sympathomimetic agents. Adrenaline and dopamine should be avoided, because beta stimulation may worsen hypotension when Quetiapine Fumarate-induced alpha blockade is present. The patient should stay under close medical supervision and monitoring until they recover.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Quetiapine Fumarate out of the sight and reach of children. Don't use it after the expiry date printed on the blister pack and the carton. The expiry date means the last day of that month. Store the medicine in a cool, dry place, away from light.
Drug Interactions
Common questions about Queta 100 mg
What is Queta 100 mg Tablet?
Queta 100 mg Tablet is a medicine that contains Quetiapine Fumarate. It is made by Opsonin Pharma Limited. It belongs to the Atypical neuroleptic drugs group of medicines.
What is Queta used for?
Queta is used for: Schizophrenia, Bipolar Disorder.
What are the side effects of Queta?
Quetiapine Fumarate most often causes somnolence, dizziness and dry mouth. People may also have withdrawal (discontinuation) symptoms, weight gain and extrapyramidal symptoms.
Can I take Queta during pregnancy or while breastfeeding?
Doctors have not established whether Quetiapine is safe or effective during human pregnancy. So it should be used in pregnancy only when the benefits justify the possible risks, and the dose and the length of treatment should be kept as low and as short as possible. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Queta?
In clinical trials, people have survived acute overdoses of up to 30 grams of Quetiapine Fumarate. There is no specific antidote to Quetiapine Fumarate. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Queta?
Keep Quetiapine Fumarate out of the sight and reach of children. Don't use it after the expiry date printed on the blister pack and the carton.
Can I take other medicines with Queta?
Some medicines can interact with Quetiapine Fumarate, for example: Carbamazepine, Phenytoin. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Qtia by Naafco Pharma PLC. has the same ingredient and strength for ৳9.50 per unit, compared with ৳10.00 for Queta. Ask your doctor or pharmacist before switching.
Do I need a prescription for Queta?
Queta is a prescription (Rx) medicine. Take it as your doctor advises.