More from Proston
Other strengths and forms by Renata PLC
Indications & Uses
Proston is used to help start labour, and it widens the cervix so delivery is easier. It is also used to bring on an abortion at about 12 to 20 weeks of pregnancy. Another use is to help clear the vagina after a miscarriage.
Pharmacology
Dinoprostone is a substance that the body makes naturally. It acts as a local hormone, meaning it works on the tissue where it is found rather than travelling around the whole body. It relaxes the muscles of the cervix and makes them open up. Over time, this helps the muscle of the uterus begin to contract during labour. Its action is much like that of PGE2, also known as prostaglandin E2.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For adult patients, the recommended dose of Dinoprostone gel is 0.5 mg. After the gel is placed, the patient should remain lying on her back for 10 to 15 minutes to minimize gel leakage. In geriatrics (patients over 65 years of age), Dinoprostone gel has not been studied and is not recommended for use. In pediatrics (patients under 18 years of age), Dinoprostone gel has not been studied and is not recommended for use.
Side Effects
Common: Abnormal labor affecting the fetus, disorders of the fetal heart rate, fetal distress syndrome, and uterine hypertonus (overly strong or frequent contractions). Uncommon: Nausea, vomiting, fever, abdominal pain, and diarrhea. Rare: Disseminated intravascular coagulation, rupture of the uterus, and anaphylactic (severe allergic) reaction.
Cautions & Contraindications
Warnings & Precautions
Caution is advised when giving Proston Gel to patients with hypertonus, sustained uterine contractility, or fetal distress; hypertonic uterine contractility or tetanic uterine contractions; asthma; glaucoma; heart diseases; or depression.
Contraindications
Dinoprostone Gel should not be used in patients with known hypersensitivity to the drug or to any ingredient in the formulation, or in those for whom oxytocic drugs are unsuitable or in whom prolonged uterine contractions would be inappropriate. It should also be avoided in women with a history of cesarean section or major uterine surgery, a significant degree of cephalopelvic disproportion, or a history of difficult labor and/or traumatic delivery. Additional situations where its use is not appropriate include grand multiparae with six or more previous term pregnancies, suspected or clinically evident pre-existing fetal distress, and overdistention of the uterus such as from multiple pregnancy or polyhydramnios. It should not be given if the amniotic membranes have ruptured or chorioamnionitis is suspected, if there is unexplained vaginal bleeding during the pregnancy, or if fetal malpresentation is present. Other contraindications include gynecological, obstetrical, or medical conditions that rule out vaginal delivery; a history of epilepsy; and pregnancies complicated by an abnormal position of the placenta or umbilical cord.
Pregnancy & Breastfeeding
Dinoprostone falls under FDA pregnancy category C. It isn't recommended for use during pregnancy, labor, or delivery, and it should also be avoided by mothers who are breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Dinoprostone in a cool, dry place where the temperature doesn't go above 8°C. Protect it from light and moisture. As with all medicines, keep it out of the reach of children.
Drug Interactions
Common questions about Proston 500 mcg
What is Proston 500 mcg Cervical Gel?
Proston 500 mcg Cervical Gel is a medicine that contains Dinoprostone. It is made by Renata PLC.
What is Proston used for?
Proston is used to help start labour, and it widens the cervix so delivery is easier. It is also used to bring on an abortion at about 12 to 20 weeks of pregnancy.
What are the side effects of Proston?
Common: Abnormal labor affecting the fetus, disorders of the fetal heart rate, fetal distress syndrome, and uterine hypertonus (overly strong or frequent contractions). Uncommon: Nausea, vomiting, fever, abdominal pain, and diarrhea.
Can I take Proston during pregnancy or while breastfeeding?
Dinoprostone falls under FDA pregnancy category C. It isn't recommended for use during pregnancy, labor, or delivery, and it should also be avoided by mothers who are breastfeeding. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Proston?
Keep Dinoprostone in a cool, dry place where the temperature doesn't go above 8°C. Protect it from light and moisture.
Can I take other medicines with Proston?
Some medicines can interact with Dinoprostone, for example: Oxytocin. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Proston?
Proston is a prescription (Rx) medicine. Take it as your doctor advises.