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All price changes →Polymix G
Rx25 IU+1700 IU+5000 IU • Ophthalmic Solution
Indications & Uses
Gramicidin, Neomycin and Polymyxin B Sulfates ophthalmic solution is used on the eye to treat superficial infections of the external eye and its adnexa, when the infection is caused by susceptible bacteria. These infections include conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis.
Pharmacology
Neomycin kills many gram-positive and gram-negative bacteria. It is an aminoglycoside antibiotic, and it stops bacteria making protein by binding to ribosomal RNA, which makes the bacterial genetic code get misread.
Polymyxin B kills a variety of gram-negative organisms. It makes the bacterial cell membrane more permeable by interacting with the phospholipid components of the membrane.
Gramicidin kills a variety of gram-positive organisms. It also makes the cell membrane more permeable, in this case to inorganic cations, by forming a network of channels through the normal lipid bilayer of the membrane.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Put one or two drops of Gramacidin + Neomycin + Polymixin B into the affected eye every 4 hours, for 7 to 10 days. If the infection is severe, the dose may be raised to as much as two drops every hour.
Side Effects
Side effects have been reported with the anti-infective components of Gramacidin + Neomycin + Polymixin B, but how often they happen is not known. The reactions seen most often are allergic ones, such as itching, swelling and redness of the conjunctiva (conjunctival erythema). More serious hypersensitivity reactions, including anaphylaxis, have been reported rarely. Some people have also had local irritation when the drops were put into the eye.
Cautions & Contraindications
Warnings & Precautions
As with other antibiotic preparations, using Gramacidin + Neomycin + Polymixin B for a long time may allow organisms that the medicine can't kill to overgrow, including fungi. If a superinfection occurs, appropriate measures should be started. Bacterial resistance to Gramacidin + Neomycin + Polymixin B may also develop. If purulent discharge, inflammation or pain gets worse, the patient should stop using the medicine and consult a physician. There have been reports of bacterial keratitis linked to topical ophthalmic products in multiple-dose containers that patients had contaminated by accident. Most of these patients already had a corneal disease or a break in the surface layer of the eye (the ocular epithelium). Allergic cross-reactions may occur, and these could rule out the use of any or all of these antibiotics for treating future infections: kanamycin, paromomycin, streptomycin, and possibly gentamicin.
Contraindications
Don't use this product if you have ever shown hypersensitivity to any of its components, which are Gramacidin, Neomycin and Polymixin B.
Pregnancy & Breastfeeding
Pregnancy Category C. No adequate animal reproductive studies have been done with gramicidin, neomycin and polymyxin B. It's also not known whether this product can harm the fetus when given to a pregnant woman, or whether it can affect the ability to reproduce. So it should be given to a pregnant woman only if clearly needed.
Nursing Mothers: It's not known whether this drug passes into human milk. Many drugs do pass into human milk, so caution should be exercised when this product is given to a nursing woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric Use
Safety and effectiveness of Gramacidin + Neomycin + Polymixin B in children have not been established.
Storage
Keep this medicine in a cool, dry place.
Common questions about Polymix G 25 IU+1700 IU+5000 IU
What is Polymix G 25 IU+1700 IU+5000 IU Ophthalmic Solution?
Polymix G 25 IU+1700 IU+5000 IU Ophthalmic Solution is a medicine that contains Gramacidin + Neomycin + Polymixin B. It is made by OSL Pharma Ltd. It belongs to the Ophthalmic antibacterial drugs group of medicines.
What is Polymix G used for?
Gramicidin, Neomycin and Polymyxin B Sulfates ophthalmic solution is used on the eye to treat superficial infections of the external eye and its adnexa, when the infection is caused by susceptible bacteria. These infections include conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis.
What are the side effects of Polymix G?
Side effects have been reported with the anti-infective components of Gramacidin + Neomycin + Polymixin B, but how often they happen is not known. The reactions seen most often are allergic ones, such as itching, swelling and redness of the conjunctiva (conjunctival erythema).
Can I take Polymix G during pregnancy or while breastfeeding?
Pregnancy Category C. No adequate animal reproductive studies have been done with gramicidin, neomycin and polymyxin B. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Polymix G?
Keep this medicine in a cool, dry place.
Do I need a prescription for Polymix G?
Polymix G is a prescription (Rx) medicine. Take it as your doctor advises.