Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →Indications & Uses
Pitavastatin Calcium is used alongside diet in people with primary hyperlipidemia and mixed dyslipidemia. It helps lower raised total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B) and triglycerides (TG), and it helps raise high-density lipoprotein cholesterol (HDL-C).
Pharmacology
Pitavastatin works by competitively inhibiting HMG-CoA reductase, the rate-determining enzyme in the making of cholesterol. It competes with the substrate for the enzyme, and this blocks cholesterol synthesis in the liver. The liver then produces more LDL-receptors, so more LDL is taken up from the blood into the liver, and plasma TC falls. Pitavastatin also keeps cholesterol synthesis in the liver suppressed over time, and this lowers the levels of very low density lipoproteins.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
General Dosing Information
Pitavastatin is taken by mouth once daily, at any time of the day, with or without food. The dose range is 1 to 4 mg. The recommended starting dose is 2 mg and the maximum dose is 4 mg. Both the starting dose and the maintenance doses should be individualized according to patient characteristics, such as goal of therapy and response. After pitavastatin is started, or after the dose is titrated, lipid levels should be analyzed after 4 weeks and the dosage adjusted accordingly.
Dosage in Patients with Renal Impairment
Moderate and severe renal impairment mean a glomerular filtration rate of 30-59 mL/min/1.73 m2 and 15-29 mL/min/1.73 m2 respectively, in patients not receiving hemodialysis. Patients with either of these, and patients with end-stage renal disease receiving hemodialysis, should start on pitavastatin 1 mg once daily. Their maximum dose is pitavastatin 2 mg once daily.
Use with Erythromycin
In patients taking erythromycin, a dose of pitavastatin 1 mg once daily should not be exceeded.
Use with Rifampin
In patients taking rifampin, a dose of pitavastatin 2 mg once daily should not be exceeded.
Side Effects
With Pitavastatin Calcium, the reactions people report most often are muscle pain (myalgia), back pain, diarrhoea, constipation and pain in the arms or legs.
Cautions & Contraindications
Warnings & Precautions
Skeletal muscle effects such as myopathy and rhabdomyolysis can occur with pitavastatin. The risk rises in a dose-dependent manner. It is also higher with advanced age (>65), renal impairment, inadequately treated hypothyroidism, and use together with fibrates. Patients should be advised to report unexplained muscle pain, tenderness or weakness promptly. If any of these signs or symptoms appear, pitavastatin should be stopped. Liver enzyme abnormalities need monitoring too. Persistent elevations in hepatic transaminases can occur, so liver enzymes should be checked before treatment and during it.
Contraindications
Pitavastatin Calcium must not be used by anyone with a known hypersensitivity to it. It is also not for people with active liver disease, which may include unexplained persistent elevations in hepatic transaminase levels. Women who are pregnant or may become pregnant should not take it, and it must not be given together with cyclosporine.
Pregnancy & Breastfeeding
Pitavastatin is Pregnancy Category X, so it must not be used by women who are pregnant or who may become pregnant. Nobody knows yet whether pitavastatin passes into human breast milk. Another medicine in the same class has been shown to pass a small amount into milk, though. For this reason, women who need treatment with pitavastatin should be advised not to breastfeed their infants, or to stop pitavastatin.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Pitavastatin Calcium in a cool, dry place and protect it from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Pivasta 2 mg
What is Pivasta 2 mg Tablet?
Pivasta 2 mg Tablet is a medicine that contains Pitavastatin Calcium. It is made by Eskayef Pharmaceuticals Ltd. It belongs to the Other Anti-anginal & Anti-ischaemic drugs group of medicines.
What is Pivasta used for?
Pitavastatin Calcium is used alongside diet in people with primary hyperlipidemia and mixed dyslipidemia. It helps lower raised total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B) and triglycerides (TG), and it helps raise high-density lipoprotein cholesterol (HDL-C).
What are the side effects of Pivasta?
With Pitavastatin Calcium, the reactions people report most often are muscle pain (myalgia), back pain, diarrhoea, constipation and pain in the arms or legs.
Can I take Pivasta during pregnancy or while breastfeeding?
Pitavastatin is Pregnancy Category X, so it must not be used by women who are pregnant or who may become pregnant. Nobody knows yet whether pitavastatin passes into human breast milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Pivasta?
Keep Pitavastatin Calcium in a cool, dry place and protect it from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Pivasta?
Some medicines can interact with Pitavastatin Calcium, for example: Cyclosporine, Erythromycin, Rifampicin, Gemfibrozil, Warfarin Sodium. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Pivasta is already among the lowest-priced brands of Pitavastatin Calcium at this strength.
Do I need a prescription for Pivasta?
Pivasta is a prescription (Rx) medicine. Take it as your doctor advises.