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Same active ingredient — pay up to 1% less
These brands contain the same active ingredient (Ropinirole). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Perkirol
Other strengths and forms by Square Pharmaceuticals PLC, Pabna
Indications & Uses
Perkirol is indicated for:
Pharmacology
Ropinirole is a non-ergoline dopamine agonist. Among the dopamine receptor subtypes, it binds most strongly to D3 receptors, which are concentrated in the limbic areas of the brain and may account for some of its neuropsychiatric effects. How ropinirole works in Parkinson's disease is not fully understood, but it is thought to relate to its ability to selectively stimulate dopamine D2 receptors within the caudate-putamen system, which governs body movement. It shows negligible affinity for peripheral α2 adrenoreceptors and 5HT-1 receptors, and no affinity at all for D1-like, benzodiazepine, or GABA receptors. Its mechanism in Restless Legs Syndrome is likewise not fully understood, but is thought to stem from its ability to stimulate dopamine receptors.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosing for Parkinson's disease: The recommended starting dose for Parkinson's disease is 0.25 mg three times daily. Based on individual patient therapeutic response and tolerability, the dosing should then be titrated with weekly increments as needed, as described below. Maximum recommended total daily dose is 24 mg (8 mg three times daily).
Week 1: 0.25 mg three times daily. Total daily dose 0.75 mg.
Week 2: 0.5 mg three times daily. Total daily dose 1.50 mg.
Week 3: 0.75 mg three times daily. Total daily dose 2.25 mg.
Week 4: 1 mg three times daily. Total daily dose 3 mg.
Dosing for Restless Legs Syndrome: The recommended adult starting dose for RLS is 0.25 mg once daily, taken 1 to 3 hours before bedtime. After 2 days, if necessary, the dose can be increased to 0.5 mg once daily, and to 1 mg once daily at the end of the first week of dosing, then adjusted further as shown below as needed to achieve efficacy. Dosing titration should be based on individual patient therapeutic response and tolerability, up to a maximum recommended dose of 4 mg daily.
Days 1 and 2: 0.25 mg once daily, 1 to 3 hours before bedtime.
Days 3 to 7: 0.5 mg once daily, 1 to 3 hours before bedtime.
Day 2 (of further titration): 1 mg once daily, 1 to 3 hours before bedtime.
Day 3: 1.5 mg once daily, 1 to 3 hours before bedtime.
Day 4: 2 mg once daily, 1 to 3 hours before bedtime.
Day 5: 2.5 mg once daily, 1 to 3 hours before bedtime.
Day 6: 3 mg once daily, 1 to 3 hours before bedtime.
Day 7: 4 mg once daily, 1 to 3 hours before bedtime.
Side Effects
Perkirol commonly causes fainting, drowsiness, hallucinations, and dizziness, along with nausea or vomiting and uncontrolled, sudden movements. Some people also experience swelling in the legs, fatigue, confusion, headache, an upset stomach, abdominal pain or discomfort, and increased sweating, among other effects.
Cautions & Contraindications
Warnings & Precautions
Patients treated with Perkirol have reported falling asleep while engaged in daily activities. Dopamine agonists, based on clinical trials and clinical experience, appear to impair the body's normal regulation of blood pressure, which can result in orthostatic hypotension.
Contraindications
This medicine should not be used by anyone who is hypersensitive to Ropinirole.
Pregnancy & Breastfeeding
Pregnancy category C. Well-controlled studies in pregnant women are lacking, so ropinirole should be used in pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus. It is also known to suppress prolactin secretion in humans, and for this reason it may reduce breast milk production.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Ropinirole away from light and moisture, and store it below 25°C. Keep it out of the reach of children.
Drug Interactions
Common questions about Perkirol 2 mg
What is Perkirol 2 mg Tablet?
Perkirol 2 mg Tablet is a medicine that contains Ropinirole. It is made by Square Pharmaceuticals PLC, Pabna. It belongs to the Antiparkinson drugs group of medicines.
What is Perkirol used for?
Perkirol is used for: Parkinson's Disease.
What are the side effects of Perkirol?
Perkirol commonly causes fainting, drowsiness, hallucinations, and dizziness, along with nausea or vomiting and uncontrolled, sudden movements. Some people also experience swelling in the legs, fatigue, confusion, headache, an upset stomach, abdominal pain or discomfort, and increased sweating, among other effects.
Can I take Perkirol during pregnancy or while breastfeeding?
Pregnancy category C. Well-controlled studies in pregnant women are lacking, so ropinirole should be used in pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Perkirol?
Keep Ropinirole away from light and moisture, and store it below 25°C. Keep it out of the reach of children.
Can I take other medicines with Perkirol?
Some medicines can interact with Ropinirole, for example: Amisulpride, Niraparib, Dopamine Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Ropinol by Incepta Pharmaceuticals Ltd. has the same ingredient and strength for ৳6.00 per unit, compared with ৳6.04 for Perkirol. Ask your doctor or pharmacist before switching.
Do I need a prescription for Perkirol?
Perkirol is a prescription (Rx) medicine. Take it as your doctor advises.