Pricing
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All price changes →Nyclobate-S
Rx0.05%+3% • Ointment
Indications & Uses
Pharmacology
Clobetasol propionate is a high-potency corticosteroid. Corticosteroids ease inflammation by stabilizing the lysosomal membranes within leukocytes, which keeps destructive acid hydrolases from being released; they curb the buildup of macrophages at inflamed sites, lessen leukocyte adhesion to capillary walls, and reduce capillary permeability and the swelling it causes. They also lower complement levels, work against histamine activity and kinin release, and cut back fibroblast growth, collagen deposition, and the scarring that follows.
Salicylic acid, when applied to the skin, acts as a strong keratolytic with a mild antiseptic effect. It draws moisture into the stratum corneum, causing the horny outer layer to swell, soften, and shed. At higher concentrations it becomes caustic, and it carries weak antifungal and antibacterial activity as well.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults: Apply a thin layer of this ointment to the affected skin areas twice daily and rub in gently and completely. For some patients, adequate maintenance therapy may be achieved with less frequent application. As with other highly active corticosteroids, therapy should be discontinued once control has been achieved. If no improvement is seen within 2 weeks, the diagnosis may need to be reassessed. It should not be used with an occlusive dressing. Treatment should not go beyond 2 consecutive weeks, and the amount used should not exceed 50 g per week, because of the potential for the drug to suppress the hypothalamic pituitary adrenal axis.
Children: Use in children under 12 years of age is not recommended.
Side Effects
As with other topical corticosteroids, using large amounts of Clobetasol Propionate for a long time, or applying it over extensive areas, can lead to enough absorption into the body to produce the features of hypercortisolism. This is more likely in infants and children, and when occlusive dressings are used. Local skin thinning (atrophy) may occur after prolonged treatment. In rare cases, treating psoriasis with corticosteroids (or stopping them) is thought to have triggered the pustular form of the disease. Clobetasol Propionate is usually well tolerated, but if signs of hypersensitivity appear, stop applying it immediately. Salicylic Acid may cause sensitivity reactions, dryness and irritation.
Cautions & Contraindications
Warnings & Precautions
Clobetasol propionate should be used with caution on lesions close to the eye. When it is applied over extensive areas for prolonged periods, enough of the drug may be absorbed to cause adrenal suppression. This is particularly true for paediatric patients, who may be more susceptible to systemic toxicity from equivalent doses because of their larger skin surface to body mass ratio. Topical corticosteroids may be hazardous in psoriasis for a number of reasons, including rebound relapses, development of tolerance, risk of generalised pustular psoriasis, and development of local or systemic toxicity due to impaired barrier function of the skin. If used in psoriasis, careful patient supervision is important. Appropriate antimicrobial therapy should be used whenever treating inflammatory lesions that have become infected. Any spread of infection requires withdrawal of topical corticosteroid therapy and systemic administration of antimicrobial agents. Bacterial infection is encouraged by the warm, moist conditions created by occlusive dressings, so the skin should be cleansed before a fresh dressing is applied. Avoid contact with broken or inflamed skin. Salicylate toxicity may occur if the preparation is applied to large areas of skin or to the skin of neonates.
Contraindications
Clobetasol propionate must not be used by anyone who is hypersensitive to it. This preparation should also not be used on skin lesions that are primarily infected by bacteria or fungi unless an anti-infective agent is used at the same time, on primary viral skin infections (such as herpes simplex, vaccinia and varicella), or on tuberculous skin lesions. Clobetasol propionate is also not to be used for skin conditions in children under one year of age, including dermatitis and nappy rash. Salicylic acid must not be used by anyone with a known hypersensitivity to salicylates, or sensitivity to any other ingredient in the preparation.
Pregnancy & Breastfeeding
Pregnancy & Breastfeeding
In animal studies, corticosteroids applied to the skin during pregnancy have been linked to abnormal fetal development, though it isn't known whether this applies to humans. The safety of Clobetasol Propionate during breastfeeding also hasn't been established. For this reason, it should only be used during pregnancy or breastfeeding if the potential benefit to the mother clearly outweighs any potential risk to the baby, and steroids of this type should not be applied over large areas of skin or used for extended periods in pregnant patients.
Salicylic Acid ointment has no known contraindications in pregnancy or breastfeeding, but its safety hasn't been formally established either, so it should also be used with caution during these periods.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Acute overdose with Clobetasol Propionate + Salicylic Acid is very unlikely. Chronic overdose or misuse is a different matter, because the features of hypercortisolism may appear. If that happens, the topical steroid should be stopped gradually. There is a risk of acute adrenal suppression, so this should be done under medical supervision.
Symptoms of systemic salicylate poisoning (tinnitus, dizziness and deafness) have been reported after Salicylic Acid was applied to large areas of skin for prolonged periods. Salicylism may also occur if large quantities are swallowed, though that is unlikely. When Salicylic Acid ointment is used as indicated, salicylism is unlikely to occur.
Salicylate poisoning is usually associated with plasma concentrations above 350 mg/L. Most adult deaths occur in patients whose concentrations exceed 700 ml/L. Single doses of less than 100 mg/kg are unlikely to cause serious poisoning.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep this medicine in a cool, dry place, away from light.
Drug Interactions
Common questions about Nyclobate-S 0.05%+3%
What is Nyclobate-S 0.05%+3% Ointment?
Nyclobate-S 0.05%+3% Ointment is a medicine that contains Clobetasol Propionate + Salicylic Acid. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Clobetasol / Clobetasone & Combined Preparations group of medicines.
What is Nyclobate-S used for?
Nyclobate-S is used for: Eczema, Psoriasis.
What are the side effects of Nyclobate-S?
As with other topical corticosteroids, using large amounts of Clobetasol Propionate for a long time, or applying it over extensive areas, can lead to enough absorption into the body to produce the features of hypercortisolism. This is more likely in infants and children, and when occlusive dressings are used.
Can I take Nyclobate-S during pregnancy or while breastfeeding?
Pregnancy & Breastfeeding In animal studies, corticosteroids applied to the skin during pregnancy have been linked to abnormal fetal development, though it isn't known whether this applies to humans. The safety of Clobetasol Propionate during breastfeeding also hasn't been established. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Nyclobate-S?
Acute overdose with Clobetasol Propionate + Salicylic Acid is very unlikely. Chronic overdose or misuse is a different matter, because the features of hypercortisolism may appear. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Nyclobate-S?
Keep this medicine in a cool, dry place, away from light.
Can I take other medicines with Nyclobate-S?
Some medicines can interact with Clobetasol Propionate + Salicylic Acid, for example: Salicylic Acid, Clobetasol Propionate. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Nyclobate-S?
Nyclobate-S is a prescription (Rx) medicine. Take it as your doctor advises.