Nyclobate-S
Rx0.05%+3% • Ointment
Indications & Uses
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults: Apply a thin layer of this ointment to the affected skin areas twice daily and rub in gently and completely. For some patients, adequate maintenance therapy may be achieved with less frequent application. As with other highly active corticosteroids, therapy should be discontinued once control has been achieved. If no improvement is seen within 2 weeks, the diagnosis may need to be reassessed. It should not be used with an occlusive dressing. Treatment should not go beyond 2 consecutive weeks, and the amount used should not exceed 50 g per week, because of the potential for the drug to suppress the hypothalamic pituitary adrenal axis. Children: Use in children under 12 years of age is not recommended.
Side Effects
As with other topical corticosteroids, using large amounts of Clobetasol Propionate for a long time, or applying it over extensive areas, can lead to enough absorption into the body to produce the features of hypercortisolism. This is more likely in infants and children, and when occlusive dressings are used. Local skin thinning (atrophy) may occur after prolonged treatment. In rare cases, treating psoriasis with corticosteroids (or stopping them) is thought to have triggered the pustular form of the disease. Clobetasol Propionate is usually well tolerated, but if signs of hypersensitivity appear, stop applying it immediately. Salicylic Acid may cause sensitivity reactions, dryness and irritation.
Cautions & Contraindications
Warnings & Precautions
Clobetasol propionate should be used with caution on lesions close to the eye. When it is applied over extensive areas for prolonged periods, enough of the drug may be absorbed to cause adrenal suppression. This is particularly true for paediatric patients, who may be more susceptible to systemic toxicity from equivalent doses because of their larger skin surface to body mass ratio. Topical corticosteroids may be hazardous in psoriasis for a number of reasons, including rebound relapses, development of tolerance, risk of generalised pustular psoriasis, and development of local or systemic toxicity due to impaired barrier function of the skin. If used in psoriasis, careful patient supervision is important. Appropriate antimicrobial therapy should be used whenever treating inflammatory lesions that have become infected. Any spread of infection requires withdrawal of topical corticosteroid therapy and systemic administration of antimicrobial agents. Bacterial infection is encouraged by the warm, moist conditions created by occlusive dressings, so the skin should be cleansed before a fresh dressing is applied. Avoid contact with broken or inflamed skin. Salicylate toxicity may occur if the preparation is applied to large areas of skin or to the skin of neonates.
Contraindications
Clobetasol propionate must not be used by anyone who is hypersensitive to it. This preparation should also not be used on skin lesions that are primarily infected by bacteria or fungi unless an anti-infective agent is used at the same time, on primary viral skin infections (such as herpes simplex, vaccinia and varicella), or on tuberculous skin lesions. Clobetasol propionate is also not to be used for skin conditions in children under one year of age, including dermatitis and nappy rash. Salicylic acid must not be used by anyone with a known hypersensitivity to salicylates, or sensitivity to any other ingredient in the preparation.