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Indications & Uses
Nerupa is indicated for:
Pharmacology
Rupatadine is a long-acting antagonist of histamine H1-receptors, and it doesn't cause sedation. It also blocks platelet activating factor (PAF). Both histamine and PAF cause broncho constriction, which leads to an increase in vascular permeability, and both act as mediators in the inflammatory process. Because Rupatadine works in these two ways, it shows a better therapeutic effect than an antihistamine that acts alone.
Rupatadine has other anti allergic properties too. It inhibits the degranulation of mast cells, whether the trigger is immunological or non immunological. It also inhibits the release of cytokines, particularly tumor necrosis factor alpha (TNF α), in human mastocytes and monocytes.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults and adolescents over 12 years should take Rupatadine at a dose of 10 mg once a day. It can be taken with or without food.
For children aged 2 to 11 years, a child weighing 25 kg or more takes 1 teaspoonful (5 ml) of the oral solution once daily, with or without food. A child weighing 10 kg or more but less than 25 kg takes 1/2 teaspoonful (2.5 ml) of the oral solution once daily, also with or without food.
Side Effects
Rupatadine Fumarate most often causes weakness (asthenia), dizziness and drowsiness. Less often, people have increased appetite, joint pain (arthralgia), back pain, poor concentration, constipation, cough, diarrhea, a dry throat, nosebleed (epistaxis), fever, stomach or gut discomfort, a higher risk of infection, irritability, a general feeling of being unwell (malaise), muscle pain (myalgia), nasal dryness, nausea, pain in the mouth and throat (oropharyngeal pain), rash, thirst, vomiting and weight gain. Rare side effects are palpitations and tachycardia.
Cautions & Contraindications
Warnings & Precautions
Take care when using Rupatadine Fumarate in patients with a known prolongation of the QT interval, uncorrected hypokalemia, or ongoing proarrhythmic conditions such as clinically significant bradycardia or acute myocardial ischemia. Caution is also needed in elderly patients (65 years and older). There is no clinical experience in patients with impaired kidney or liver function, so Rupatadine Fumarate 10 mg tablets are not recommended for these patients at present.
Pregnancy & Breastfeeding
There is no clinical data on the use of Rupatadine in pregnancy, so pregnant women should not take it unless the possible benefit is greater than the possible risk to the infant. It is also not known whether Rupatadine passes into breast milk. For that reason it shouldn't be used while breastfeeding, unless the possible benefit to the mother justifies the possible risk to the infant.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Elderly: Rupatadine Fumarate should be used with caution in elderly people. There's no information to suggest that the dose needs to be adjusted in this group.
Children: The safety and efficacy of Rupatadine Fumarate haven't been established in patients under 12 years of age.
Patients with renal or hepatic insufficiency: Rupatadine Fumarate isn't recommended in patients with renal or hepatic insufficiency, because no relevant clinical data is available.
Overdose
Somnolence was the most common adverse reaction reported with Rupatadine Fumarate. If someone accidentally takes a very high dose, the doctor should treat the symptoms and give the necessary supportive measures.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Rupatadine Fumarate in a cool, dry place below 30°C. Protect it from light and moisture, and keep it out of reach of children.
Drug Interactions
Common questions about Nerupa 5 mg/5 ml
What is Nerupa 5 mg/5 ml Oral Solution?
Nerupa 5 mg/5 ml Oral Solution is a medicine that contains Rupatadine Fumarate. It is made by Team Pharmaceuticals Ltd. It belongs to the Non-sedating antihistamines group of medicines.
What is Nerupa used for?
Nerupa is used for: Allergic Rhinitis, Urticaria.
What are the side effects of Nerupa?
Rupatadine Fumarate most often causes weakness (asthenia), dizziness and drowsiness. Less often, people have increased appetite, joint pain (arthralgia), back pain, poor concentration, constipation, cough, diarrhea, a dry throat, nosebleed (epistaxis), fever, stomach or gut discomfort, a higher risk of infection, irritability, a general feeling of being unwell (malaise), muscle pain (myalgia), nasal dryness, nausea, pain in the mouth and throat (oropharyngeal pain), rash, thirst, vomiting and weight gain.
Can I take Nerupa during pregnancy or while breastfeeding?
There is no clinical data on the use of Rupatadine in pregnancy, so pregnant women should not take it unless the possible benefit is greater than the possible risk to the infant. It is also not known whether Rupatadine passes into breast milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Nerupa?
Somnolence was the most common adverse reaction reported with Rupatadine Fumarate. If someone accidentally takes a very high dose, the doctor should treat the symptoms and give the necessary supportive measures. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Nerupa?
Keep Rupatadine Fumarate in a cool, dry place below 30°C. Protect it from light and moisture, and keep it out of reach of children.
Can I take other medicines with Nerupa?
Some medicines can interact with Rupatadine Fumarate, for example: Rupatadine, Erythromycin, Ketoconazole. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Nerupa?
Nerupa is a prescription (Rx) medicine. Take it as your doctor advises.