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Other brands with the same active ingredient
These brands contain the same active ingredient (Oxymorphone Hydrochloride). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Narco 10 is indicated for:
Pharmacology
Oxymorphone is an opioid agonist, and its main therapeutic effect is pain relief. As with all pure opioid agonist analgesics, higher doses bring greater pain relief, with no ceiling on the analgesic effect. This differs from mixed agonist/antagonist opioids or non-opioid analgesics, where pain relief plateaus even as the dose is increased. When given by injection, 1 mg of Oxymorphone Hydrochloride provides analgesia roughly equivalent to 10 mg of Morphine sulfate.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
This may be used as needed to treat acute post-surgical pain, at a dose of 5 to 10 mg every 4 hours. Take Oxymorphone Tablet on an empty stomach, at least one hour before or two hours after eating.
Dosage for other forms (2)
For subcutaneous or intramuscular administration, the initial dose is 1 mg to 1.5 mg, repeated every 4 to 6 hours as needed. For intravenous administration, the initial dose is 0.5 mg. For pain relief during labor, 0.5 mg to 1 mg given intramuscularly is recommended.
Since oral Oxymorphone has an absolute bioavailability of approximately 10%, patients may be switched from oral Oxymorphone to Oxymorphone Hydrochloride injection by giving one-tenth of the patient's total daily oral Oxymorphone dose as Oxymorphone Hydrochloride injection, split into four or six equal doses (that is, the total daily oral dose divided by 10, then by 4). For example, a patient on a total daily oral dose of 40 mg of Oxymorphone may need about 1 mg of Oxymorphone Hydrochloride injection given intramuscularly every 6 hours (4 mg total daily IM dose) for equivalent pain relief. As with any opioid medicine, the dosing regimen should be adjusted for each patient individually, taking into account their prior experience with pain-relief treatment.
Side Effects
Respiratory depression, fatigue, and asthenia may occur as general disorders. Metabolism and nutrition disorders can include anorexia. Cardiac disorders such as tachycardia, bradycardia, and palpitations have been reported, along with eye disorders like miosis, diplopia, and blurred vision. Gastrointestinal disorders may present as vomiting and constipation. Psychiatric disorders associated with this medicine include dysphoria, euphoric mood, nervousness, restlessness, insomnia, agitation, hallucination, and depression. Vascular disorders such as hypotension and flushing have also been observed.
Cautions & Contraindications
Warnings & Precautions
Opioid analgesics should be used with caution, especially when they are combined with other drugs. O-Morphon should be used carefully in elderly and debilitated patients, and in patients known to be sensitive to central nervous system depressants, such as those with cardiovascular, pulmonary, renal or hepatic disease. Caution is also needed in acute alcoholism, coma and delirium tremens. Patients with conditions that cause low oxygen (hypoxia), raised carbon dioxide (hypercapnia) or reduced respiratory reserve need extreme caution. These include asthma, chronic obstructive pulmonary disease, severe obesity, sleep apnea syndrome, myxedema, kyphoscoliosis, CNS depression, and coma. O-Morphon, like all opioid analgesics, should be started at 1/3 to 1/2 of the usual dose in patients who are also taking other central nervous system (CNS) depressants. These include sedatives or hypnotics, general anesthetics, phenothiazines, tranquilizers and alcohol. Without this, respiratory depression, low blood pressure, deep sedation, coma or death may follow. Use O-Morphon with caution in patients with mild hepatic impairment, and start with the lowest dose, for example 5 mg. The plasma levels of O-Morphon given as an extended-release tablet were about 40% higher in elderly people (65 years of age or over) than in younger subjects. So for geriatric patients, treatment may be started with O-Morphon 5 mg. Bioavailability of O-Morphon rises by 57% in patients with moderate renal impairment and by 65% in those with severe renal impairment. For renally impaired patients, treatment may therefore be started with O-Morphon 5 mg. Use O-Morphon with caution in adrenocortical insufficiency (for example, Addison's disease), prostatic hypertrophy or urethral stricture, severe impairment of pulmonary or renal function, and toxic psychosis. Opioid analgesics impair the mental and physical abilities needed for potentially hazardous activities, such as driving a car or operating machinery. Dependence: O-Morphon should not be stopped abruptly. When a patient no longer needs O-Morphon, the dose should be reduced gradually to prevent withdrawal signs and symptoms in a physically dependent patient.
Contraindications
Oxymorphone Hydrochloride (tablet and injection) should not be given to anyone with a known hypersensitivity to oxymorphone hydrochloride, to any of its other ingredients, or to morphine-type analgesics such as codeine. It is also contraindicated in patients with respiratory depression, acute or severe bronchial asthma, paralytic ileus, or moderate to severe hepatic impairment.
Pregnancy & Breastfeeding
Pregnancy Category C. Whether Oxymorphone is safe to use during pregnancy has not been established, and its potential effects on the developing fetus are unknown. Because of this, Oxymorphone should only be used during pregnancy, while breastfeeding, or in women who may become pregnant if the potential benefits to the mother are judged to outweigh the potential risks to her and the child.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: Safety and effectiveness of Oxymorphone Hydrochloride tablet and injection have not been established in patients below 18 years of age.
Geriatric use: Oxymorphone Hydrochloride tablet and injection should be used with caution in elderly patients. These adverse events included dizziness, somnolence, confusion and nausea.
Storage
Keep oxymorphone hydrochloride tablets in a cool, dry place and protect them from light. The injection should be stored at 25°C, also protected from light.
Common questions about Narco 10 10 mg
What is Narco 10 10 mg Tablet?
Narco 10 10 mg Tablet is a medicine that contains Oxymorphone Hydrochloride. It is made by Globe Pharmaceuticals Ltd. It belongs to the Opioid analgesics group of medicines.
What is Narco 10 used for?
Narco 10 is used for: Pain, Low Back Pain, Anxiety, Cancer, Edema.
What are the side effects of Narco 10?
Respiratory depression, fatigue, and asthenia may occur as general disorders. Metabolism and nutrition disorders can include anorexia.
Can I take Narco 10 during pregnancy or while breastfeeding?
Pregnancy Category C. Whether Oxymorphone is safe to use during pregnancy has not been established, and its potential effects on the developing fetus are unknown. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Narco 10?
Keep oxymorphone hydrochloride tablets in a cool, dry place and protect them from light. The injection should be stored at 25°C, also protected from light.
Do I need a prescription for Narco 10?
Narco 10 is a prescription (Rx) medicine. Take it as your doctor advises.