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All price changes →Indications & Uses
Moxifloxacin and Dexamethasone eye drop is used to treat eye infections caused by susceptible microorganisms. Doctors also use it after eye surgery, to prevent the inflammation and bacterial infection that can follow.
Pharmacology
Moxifloxacin is a broad spectrum, 4th generation fluorinated quinolone. It blocks two enzymes, topoisomerase II (DNA gyrase) and topoisomerase IV. DNA gyrase is an essential enzyme in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is known to play a key role in partitioning the chromosomal DNA when a bacterial cell divides.
Dexamethasone is a cortisone derivative with high activity, which comes from the methyl group in the 16-alpha position and the fluorine atom in the 9-alpha position. Like other glucocorticoids, it is anti-allergic, anti-exudative and anti-proliferative. It works by inhibiting phospholipase A2, the first step in prostaglandin synthesis. Dexamethasone also inhibits the chemotactic infiltration of neutrophils into the site of inflammation.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
To prevent infection and post-surgical inflammation of the eye with Moxifloxacin Hydrochloride + Dexamethasone, put 1 drop in the eye to be operated, 4 times a day. Start 1 day before surgery and continue until 15 days after surgery.
For cataract surgery, put the medicine in on the day of surgery, straight after the operation. For LASIK refractive surgery, put it in on the day of surgery at least 15 minutes after the operation.
For eye infections caused by susceptible microorganisms, the dose is 1 drop, 4 times a day, for up to 7 days.
Side Effects
Moxifloxacin can cause conjunctivitis, decreased visual acuity, dry eye, keratitis, ocular discomfort, hyperemia, pain, subconjunctival hemorrhage and tearing. Dexamethasone can cause visual acuity and field defects, cataract formation, and secondary ocular infection following suppression of the host response. It can also cause perforation of the globe.
Cautions & Contraindications
Warnings & Precautions
If you have an allergic reaction to Moxifloxacin, stop using the product and contact your doctor. Using a steroid for a long time can raise the pressure inside the eye (ocular hypertension) and may lead to glaucoma, which can damage the optic nerve. It can also cause a defect in visual acuity and in the fields of vision, posterior subcapsular cataract formation, or a greater risk of secondary eye infections. The intraocular pressure must be checked routinely. Some diseases cause thinning of the cornea or sclera (the white part of the eye). In these conditions, perforations have been known to occur when topical corticosteroids are used. In acute purulent conditions of the eye, steroids may mask an infection or make an existing infection worse.
Contraindications
Don't use Moxifloxacin Hydrochloride + Dexamethasone if you are hypersensitive to other quinolones or to any component of the product. It is also not for people with glaucoma, or with an eye disease that causes thinning of the cornea or sclera. Eye inflammation caused by a virus, fungi or mycobacteria is another contraindication. The same applies to epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella and many other viral diseases of the cornea and conjunctiva. Mycobacterial infection of the eye is also included, and so are fungal diseases of the ocular structures.
Pregnancy & Breastfeeding
No adequate and well-controlled studies have been done in pregnant women. So Moxifloxacin and Dexamethasone combination eye drops should be used in pregnancy only if the likely benefit justifies the possible risk to the fetus. Take care when the eye drops are given to women who are breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Use in the elderly
No change in dose is needed when the product is given to elderly patients.
Use in children
The efficacy and safety of Moxifloxacin and Dexamethasone combination eye drops have not been established in children.
Overdose
There is no information on overdosage of Moxifloxacin Hydrochloride + Dexamethasone in humans.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Moxifloxacin Hydrochloride + Dexamethasone in a cool place, below 30°C, and away from light. Once you open the container, use the contents within 28 days. During that time it can be kept at room temperature, up to 30°C. Throw away whatever is left after the 28 days. Keep it out of reach of children.
Common questions about Moxigram-D 0.5%+0.1%
What is Moxigram-D 0.5%+0.1% Ophthalmic Solution?
Moxigram-D 0.5%+0.1% Ophthalmic Solution is a medicine that contains Moxifloxacin Hydrochloride + Dexamethasone. It is made by Apex Pharma Ltd. It belongs to the 4-Quinolone preparations group of medicines.
What is Moxigram-D used for?
Moxifloxacin and Dexamethasone eye drop is used to treat eye infections caused by susceptible microorganisms. Doctors also use it after eye surgery, to prevent the inflammation and bacterial infection that can follow.
What are the side effects of Moxigram-D?
Moxifloxacin can cause conjunctivitis, decreased visual acuity, dry eye, keratitis, ocular discomfort, hyperemia, pain, subconjunctival hemorrhage and tearing. Dexamethasone can cause visual acuity and field defects, cataract formation, and secondary ocular infection following suppression of the host response.
Can I take Moxigram-D during pregnancy or while breastfeeding?
No adequate and well-controlled studies have been done in pregnant women. So Moxifloxacin and Dexamethasone combination eye drops should be used in pregnancy only if the likely benefit justifies the possible risk to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Moxigram-D?
There is no information on overdosage of Moxifloxacin Hydrochloride + Dexamethasone in humans. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Moxigram-D?
Keep Moxifloxacin Hydrochloride + Dexamethasone in a cool place, below 30°C, and away from light. Once you open the container, use the contents within 28 days.
Do I need a prescription for Moxigram-D?
Moxigram-D is a prescription (Rx) medicine. Take it as your doctor advises.