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Indications & Uses
Methylergonovine Maleate is used after the placenta has been delivered, for routine management of uterine atony, hemorrhage and subinvolution of the uterus. It is also used to control uterine hemorrhage in the second stage of labor, after the anterior shoulder has been delivered.
Pharmacology
Methylergonovine Maleate acts directly on the smooth muscle of the uterus. It increases the tone, the rate and the strength of the rhythmic contractions. This gives a rapid and sustained tetanic uterotonic effect, so the third stage of labor is shorter and blood loss is reduced.
After I.V. administration the effect starts immediately. After I.M. administration it starts in 2 to 5 minutes, and after oral administration in 5 to 10 minutes.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Intramuscularly, the dose is 1 ml (0.2 mg). It is given after delivery of the anterior shoulder, after delivery of the placenta, or during the puerperium. It may be repeated as required, at intervals of 2 to 4 hours.
Intravenously, the dose is 1 ml (0.2 mg), given slowly over no less than 60 seconds.
Orally, take one tablet of 0.2 mg, 3 or 4 times daily in the puerperium, for a maximum of 1 week.
Side Effects
The most common side effect of Methylergonovine Maleate is high blood pressure (hypertension), and in several cases it came with seizure and/or headache. Low blood pressure has also been reported. Abdominal pain, which comes from the uterine contractions, nausea and vomiting have occurred occasionally. Some reactions are rare. These include acute myocardial infarction, transient chest pains, vasoconstriction, vasospasm, coronary arterial spasm, bradycardia, tachycardia, dyspnea, hematuria, thrombophlebitis, water intoxication, hallucinations, leg cramps, dizziness, tinnitus, nasal congestion, diarrhea, diaphoresis, palpitation, rash and a foul taste. There have also been a few rare, isolated reports of anaphylaxis, but a causal link with the medicine has not been proven.
Cautions & Contraindications
Warnings & Precautions
Take care when using Methylergonovine Maleate in people with sepsis or obliterative vascular disease. Be careful during the second stage of labour too. With the right technique, and enough time allowed for the placenta to separate on its own, manual removal of a retained placenta should be needed only rarely.
Pregnancy & Breastfeeding
Methylergonovine is in Pregnancy Category C. Animal reproductive studies haven't been done with it, and it isn't known whether methylergonovine maleate can harm the fetus or affect reproductive capacity. Because of its uterotonic effects, Methylergonovine is contraindicated during pregnancy.
Mothers should not breast-feed while being treated with Methylergonovine, and any milk produced during this time should be discarded. The medicine may cause adverse effects in the breast-feeding infant, and it may also reduce the amount of breast milk. After the last dose, a mother should wait at least 12 hours before starting or resuming breast-feeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Methylergonovine Maleate has not been shown to be safe or effective in children.
Overdose
An acute overdose of Methylergonovine Maleate can cause nausea, vomiting, oliguria, abdominal pain, and numbness and tingling in the extremities. Blood pressure may rise, and in severe cases it is followed by hypotension. Respiratory depression, hypothermia, convulsions and coma can also occur.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store below 25°C in a tight container that keeps out light.
Drug Interactions
Common questions about Metherspan 125 mcg
What is Metherspan 125 mcg Tablet?
Metherspan 125 mcg Tablet is a medicine that contains Methylergonovine Maleate. It is made by Opsonin Pharma Limited. It belongs to the Drugs acting on the Uterus group of medicines.
What is Metherspan used for?
Methylergonovine Maleate is used after the placenta has been delivered, for routine management of uterine atony, hemorrhage and subinvolution of the uterus. It is also used to control uterine hemorrhage in the second stage of labor, after the anterior shoulder has been delivered.
What are the side effects of Metherspan?
The most common side effect of Methylergonovine Maleate is high blood pressure (hypertension), and in several cases it came with seizure and/or headache. Low blood pressure has also been reported.
Can I take Metherspan during pregnancy or while breastfeeding?
Methylergonovine is in Pregnancy Category C. Animal reproductive studies haven't been done with it, and it isn't known whether methylergonovine maleate can harm the fetus or affect reproductive capacity. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Metherspan?
An acute overdose of Methylergonovine Maleate can cause nausea, vomiting, oliguria, abdominal pain, and numbness and tingling in the extremities. Blood pressure may rise, and in severe cases it is followed by hypotension. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Metherspan?
Store below 25°C in a tight container that keeps out light.
Can I take other medicines with Metherspan?
Some medicines can interact with Methylergonovine Maleate, for example: Lopinavir + Ritonavir, Erythromycin, Fluconazole, Clotrimazole, Clarithromycin, Itraconazole. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Metherspan is already among the lowest-priced brands of Methylergonovine Maleate at this strength.
Do I need a prescription for Metherspan?
Metherspan is a prescription (Rx) medicine. Take it as your doctor advises.