More from Metafen
Other strengths and forms by Incepta Pharmaceuticals Ltd.
Indications & Uses
Metafen is indicated for:
Pharmacology
Paracetamol is a para-aminophenol derivative. It relieves pain and reduces fever, and its anti-inflammatory activity is weak. Its pain-relieving effect may come from blocking prostaglandin synthesis in the central nervous system and from modulating the inhibitory descending serotonergic pathways. The fever-reducing effect may be due to less prostaglandin being produced in the hypothalamus.
Ibuprofen is an NSAID with pain-relieving, anti-inflammatory and fever-reducing properties. It inhibits the COX-1 and COX-2 enzymes, and in doing so it also blocks prostaglandin synthesis.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Take the Ibuprofen + Paracetamol tablet by mouth, with food.
The recommended dose is one 200/500 tablet or two 125/250 tablets, three times daily (every 8 hours). If necessary, you can take a maximum of two 200/500 tablets three times daily. Leave at least six hours between doses. Don't take more than 3000 mg paracetamol and 1200 mg ibuprofen in any 24 hour period.
Safety and effectiveness have not been established in children and adolescents below 18 years of age.
Side Effects
Ibuprofen with Paracetamol most commonly causes abdominal pain and discomfort, vomiting, diarrhoea, nausea and dyspepsia. Some people also sweat a lot (hyperhidrosis). Blood tests may show a rise in serum creatinine and blood urea, and liver function tests can come back abnormal.
Cautions & Contraindications
Warnings & Precautions
Take care when giving Ibuprofen + Paracetamol to patients who have, or have had, bronchial asthma or an allergic disease. The same goes for hypertension, mild to moderate CHF, mixed connective tissue disorder, SLE, non-cirrhotic alcoholic liver disease, G6PD deficiency, chronic malnutrition, anorexia, bulimia, cachexia, dehydration and hypovolemia. Elderly patients also need care. Check the patient regularly for gastrointestinal bleeding. Renal function should be monitored in people with renal, cardiac or liver impairment, in those taking diuretics, and in the elderly.
Contraindications
Don't take the ibuprofen and paracetamol combination if you have ever had a known hypersensitivity to it, to acetylsalicylic acid, to other NSAIDs, or to any other component of the product. It is also contraindicated if you have a history of gastrointestinal ulceration, perforation or bleeding, or have one now, including when it was linked to NSAIDs. The same applies to defects in coagulation, severe hepatic failure, severe renal failure and severe heart failure (NYHA Class IV).
Pregnancy & Breastfeeding
Pregnancy: No well controlled studies have been done in pregnant women exposed to the combination of ibuprofen and paracetamol, so the risk of major birth defects, miscarriage or harmful outcomes for the mother or baby is not known. Avoid this combination in the first six months of pregnancy. In the last three months of pregnancy it is contraindicated.
Lactation: Paracetamol passes into breast milk, but not in an amount that matters clinically. For short-term treatment at the recommended dose, there is no need to stop breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
An overdose of ibuprofen and paracetamol can cause pallor, nausea, vomiting, abdominal pain, drowsiness and convulsions. Damage to the liver or kidneys may also occur. Treatment is based on the symptoms the person has. Activated charcoal should be considered within 1 hour of the overdose, and N-acetylcysteine can be given up to 24 hours after it.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep the Ibuprofen + Paracetamol tablets in a dry place below 30°C, and away from light. Make sure children can't reach them.
Drug Interactions
Common questions about Metafen 200 mg
What is Metafen 200 mg Tablet?
Metafen 200 mg Tablet is a medicine that contains Ibuprofen + Paracetamol. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Non-steroidal Anti-inflammatory Drugs (NSAIDs) group of medicines.
What is Metafen used for?
Metafen is used for: Pharyngitis, Migraine, Headache, Pain, Fever.
What are the side effects of Metafen?
Ibuprofen with Paracetamol most commonly causes abdominal pain and discomfort, vomiting, diarrhoea, nausea and dyspepsia. Some people also sweat a lot (hyperhidrosis).
Can I take Metafen during pregnancy or while breastfeeding?
Pregnancy: No well controlled studies have been done in pregnant women exposed to the combination of ibuprofen and paracetamol, so the risk of major birth defects, miscarriage or harmful outcomes for the mother or baby is not known. Avoid this combination in the first six months of pregnancy. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Metafen?
An overdose of ibuprofen and paracetamol can cause pallor, nausea, vomiting, abdominal pain, drowsiness and convulsions. Damage to the liver or kidneys may also occur. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Metafen?
Keep the Ibuprofen + Paracetamol tablets in a dry place below 30°C, and away from light. Make sure children can't reach them.
Can I take other medicines with Metafen?
Some medicines can interact with Ibuprofen + Paracetamol, for example: Paracetamol, Zidovudine, Domperidone, Tacrolimus, Cholestyramine, Mifepristone. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Metafen?
Metafen is a prescription (Rx) medicine. Take it as your doctor advises.