Pricing
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Same active ingredient — pay up to 6% less
These brands contain the same active ingredient (Omarigliptin). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Makario
Other strengths and forms by Incepta Pharmaceuticals Ltd.
Indications & Uses
Makario is indicated for:
Pharmacology
Omarigliptin is a long-acting inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). This enzyme breaks down incretin hormones very quickly. Incretins help lower blood glucose after a meal, because they raise insulin and lower glucagon levels, and they do this only in response to glucose. By blocking DPP-4, Omarigliptin boosts the action of these incretin hormones.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Omarigliptin tablets should be taken by mouth. The recommended dose of omarigliptin is 25 mg once weekly, either as monotherapy or as add-on therapy for optimisation of glycemic control. If a patient misses a dose, advise them to take the missed dose as soon as possible and then carry on with the regular weekly schedule. Never take two doses at one time.
For renal impairment, the dose in patients with severe renal dysfunction, end-stage renal failure, or those who need hemodialysis or peritoneal dialysis should follow the values below. In severe end-stage kidney failure, men with CrCl>1.9 take 12.5 mg once a week, and women with CrCl >1.4 take 12.5 mg once a week.
The safety and efficacy of omarigliptin in children and adolescents have not been established.
Side Effects
Most people tolerate Omarigliptin well. The side effects seen most often are nasopharyngitis, hypoglycemia, constipation, diarrhea, gastrointestinal problems, and disorders of the skin and subcutaneous tissue.
Cautions & Contraindications
Warnings & Precautions
Use Omarigliptin with caution in patients who have, or may develop, conditions that can cause low blood sugar. These include pituitary dysfunction or adrenal insufficiency, malnutrition, starvation, irregular or poor dietary intake, a debilitated state, intense muscle movement, and excessive alcohol intake. Elderly people also need caution. Take care as well with patients who do aerial work or drive an automobile.
Contraindications
Don't give omarigliptin to anyone who is hypersensitive to omarigliptin or to any other component of the product. It is also contraindicated in severe ketosis, and in diabetic coma or precoma in people with type 1 diabetes. Other situations where it must not be used are severe infection where blood glucose is to be controlled with insulin injection, the period before and after surgery, and severe trauma.
Pregnancy & Breastfeeding
Nobody has tested omarigliptin in pregnant women in clinical trials. So it should be used during pregnancy only if the likely benefit to the mother justifies the possible risk to the fetus. Mothers who are taking omarigliptin should avoid breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
There is no data on overdose with Omarigliptin. If an overdose does happen, supportive care is advised.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Omarigliptin in a cool, dry place, below 30°C, and away from light. Make sure children can't reach it.
Drug Interactions
Common questions about Makario 12.5 mg
What is Makario 12.5 mg Tablet?
Makario 12.5 mg Tablet is a medicine that contains Omarigliptin. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Dipeptidyl Peptidase-4 (DPP-4) inhibitor group of medicines.
What is Makario used for?
Makario is used for: Type 2 Diabetes Mellitus, Diabetes Mellitus.
What are the side effects of Makario?
Most people tolerate Omarigliptin well. The side effects seen most often are nasopharyngitis, hypoglycemia, constipation, diarrhea, gastrointestinal problems, and disorders of the skin and subcutaneous tissue.
Can I take Makario during pregnancy or while breastfeeding?
Nobody has tested omarigliptin in pregnant women in clinical trials. So it should be used during pregnancy only if the likely benefit to the mother justifies the possible risk to the fetus. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Makario?
There is no data on overdose with Omarigliptin. If an overdose does happen, supportive care is advised. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Makario?
Keep Omarigliptin in a cool, dry place, below 30°C, and away from light. Make sure children can't reach it.
Can I take other medicines with Makario?
Some medicines can interact with Omarigliptin, for example: Atorvastatin, Glimepiride, Adrenaline, Salicylic Acid, Metformin, Insulin (Human) 30/70. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Omariglip by Orion Pharma Ltd. has the same ingredient and strength for ৳75.00 per unit, compared with ৳80.00 for Makario. Ask your doctor or pharmacist before switching.
Do I need a prescription for Makario?
Makario is a prescription (Rx) medicine. Take it as your doctor advises.