Pricing
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Lurbin is indicated for:
Pharmacology
Lurbinectedin is an alkylating drug. It binds to guanine residues in the minor groove of DNA and forms adducts, which bend the DNA helix towards the major groove. These adducts set off a cascade of events that can change how DNA binding proteins work later on, including some transcription factors, and they also affect DNA repair pathways. The result is disturbance of the cell cycle and, in the end, cell death. In laboratory studies (in vitro), lurbinectedin inhibited the activity of human monocytes, and in mice it reduced macrophage infiltration in implanted tumors.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended dose of Lurbinectedin is 3.2 mg/m2, given by intravenous infusion over 60 minutes every 21 days. Treatment continues until the disease progresses or the toxicity becomes unacceptable. Initiate treatment with Lurbinectedin only if the absolute neutrophil count (ANC) is at least 1,500 cells/mm3 and the platelet count is at least 100,000/mm3.
Side Effects
The most common side effects of Lurbinectedin, including changes seen in laboratory tests, each affect 20% or more of people. These are leukopenia, lymphopenia, fatigue, anemia and neutropenia. Also common are increased creatinine, increased alanine aminotransferase, increased glucose, thrombocytopenia, nausea and decreased appetite. The list continues with musculoskeletal pain, decreased albumin, constipation, dyspnea, decreased sodium, increased aspartate aminotransferase and vomiting. Cough, decreased magnesium and diarrhea complete it.
Cautions & Contraindications
Warnings & Precautions
Myelosuppression: Check blood counts before every dose. Start Lurbin only if the baseline neutrophil count is 1,500 cells/mm3 or above and the platelet count is 100,000/mm3 or above. Depending on how severe the problem is, withhold the medicine, reduce the dose or stop it permanently. Hepatotoxicity: Check liver function tests before starting Lurbin, then periodically during treatment and whenever clinically needed. Depending on severity, withhold the medicine, reduce the dose or stop it permanently. Extravasation resulting in tissue necrosis: Consider using a central venous catheter to reduce the risk of extravasation. Watch the patient for signs and symptoms of extravasation throughout the infusion. If it happens, stop the infusion immediately, remove the infusion catheter and keep monitoring for signs and symptoms of tissue necrosis. Rhabdomyolysis: Check creatine phosphokinase (CPK) before starting Lurbin and periodically during treatment, as clinically indicated. Depending on severity, withhold the medicine, reduce the dose or stop it permanently. Embryo-fetal toxicity: Lurbin can cause fetal harm. Females and males of reproductive potential should be told about the potential risk to a fetus and advised to use an effective method of contraception.
Pregnancy & Breastfeeding
Animal data and the way lurbinectedin works suggest it can harm an unborn baby if a pregnant woman is given it. There is no data on the risk of using lurbinectedin in pregnant women, so the actual risk isn't known. Nor is there any data on whether lurbinectedin passes into human milk, what it does to a breastfed child, or whether it affects milk production. Because lurbinectedin could cause serious adverse reactions in a breastfed child, women should be advised not to breastfeed during treatment and for 2 weeks after the last dose.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Lurbinectedin below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Common questions about Lurbin 4 mg
What is Lurbin 4 mg IV Injection?
Lurbin 4 mg IV Injection is a medicine that contains Lurbinectedin. It is made by Eskayef Pharmaceuticals Ltd.
What is Lurbin used for?
Lurbin is used for: Cancer.
What are the side effects of Lurbin?
The most common side effects of Lurbinectedin, including changes seen in laboratory tests, each affect 20% or more of people. These are leukopenia, lymphopenia, fatigue, anemia and neutropenia.
Can I take Lurbin during pregnancy or while breastfeeding?
Animal data and the way lurbinectedin works suggest it can harm an unborn baby if a pregnant woman is given it. There is no data on the risk of using lurbinectedin in pregnant women, so the actual risk isn't known. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Lurbin?
Store Lurbinectedin below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Do I need a prescription for Lurbin?
Lurbin is a prescription (Rx) medicine. Take it as your doctor advises.