Indications & Uses
Lurbin is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The recommended dosage of Lurbinectedin is 3.2 mg/m2 by intravenous infusion over 60 minutes every 21 days until disease progression or unacceptable toxicity.Initiate treatment with Lurbinectedin only if absolute neutrophil count (ANC) is at least 1,500 cells/mm3 and platelet count is at least 100,000/mm3.
Side Effects
The most common adverse reactions, including laboratory abnormalities, (≥20%) are leukopenia, lymphopenia, fatigue, anemia, neutropenia, increased creatinine, increased alanine aminotransferase, increased glucose,thrombocytopenia, nausea, decreased appetite, musculoskeletal pain, decreased albumin, constipation, dyspnea, decreased sodium, increased aspartate aminotransferase, vomiting, cough, decreased magnesium and diarrhea.
Cautions & Contraindications
Warnings & Precautions
Myelosuppression: Monitor blood counts prior to each administration. Initiate treatment with Lurbin only if baseline neutrophil count is ≥1,500 cells/mm3 and platelet count is ≥100,000/mm3. Withhold, reduce the dose, or permanently discontinue Lurbin based on severity.Hepatotoxicity: Monitor liver function tests prior to initiating Lurbin, periodically during treatment and as clinically indicated. Withhold, reduce the dose, or permanently discontinue Lurbin based on severity.Extravasation Resulting in Tissue Necrosis: Consider use of a central venous catheter to reduce the risk of extravasation. Monitor patients for signs and symptoms of extravasation during the Lurbin infusion. If extravasation occurs, immediately discontinue the infusion, remove the infusion catheter, and monitor for signs and symptoms of tissue necrosis.Rhabdomyolysis: Monitor creatine phosphokinase (CPK) prior to initiating Lurbin and periodically during treatment as clinically indicated. Withhold, reduce the dose, or permanently discontinue Lurbin based on severity.Embryo-Fetal Toxicity: Can cause fetal harm. Advise females and males of reproductive potential of the potential risk to a fetus and to use an effective method of contraception.