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Indications & Uses
Lanthanum Carbonate is a phosphate binder. Doctors use it to lower the level of phosphate in the blood (serum phosphate) in patients with end-stage renal disease (ESRD).
Pharmacology
Lanthanum Carbonate is a phosphate binder. It forms insoluble Lanthanum phosphate complexes that pass through the Gl tract without being absorbed, so less phosphate gets into the body. Because less dietary phosphate is absorbed, both serum phosphate and calcium phosphate product go down.
In vitro studies show that Lanthanum binds phosphate across the physiologically relevant pH range of 3 to 7. In simulated gastric fluid, when Lanthanum is present in a two-fold molar excess to phosphate, it binds approximately 97% of the available phosphate at pH 3-5 and 67% at pH 7. Bile acids have not been shown to affect how well Lanthanum binds phosphate.
To bind dietary phosphate, Lanthanum Carbonate must be taken with meals or immediately after them.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults usually start Lanthanum Carbonate at a total daily dose of 1,500 mg, divided into separate doses. The doctor then adjusts the dose every 2 to 3 weeks, depending on the serum phosphate level. Take it with meals or straight after them.
Lanthanum Carbonate chewable tablets must not be swallowed whole. Chew them or crush them completely before swallowing.
Side Effects
The most common side effects seen with Lanthanum Carbonate were stomach and bowel problems, such as nausea, vomiting and abdominal pain. These usually eased over time as people kept taking the medicine. Since the medicine was approved, a few more reactions have been reported with Lanthanum Carbonate: constipation, dyspepsia, allergic skin reactions, and tooth injury while chewing the tablet.
Cautions & Contraindications
Warnings & Precautions
Gastrointestinal adverse effects have been reported in patients taking Lanthanum Carbonate. Serious cases of gastrointestinal obstruction, ileus, subileus, gastrointestinal perforation and fecal impaction have occurred, and some patients needed surgery or hospitalization. Doctors and patients should stay alert during treatment for signs and symptoms of gastrointestinal disorders, especially constipation and abdominal pain or distention, because these may point to bowel obstruction, ileus or subileus. If a patient develops severe constipation or other severe gastrointestinal signs and symptoms, treatment should be re-evaluated. Patients who are prescribed Lanthanum Carbonate Chewable Tablets should be told to chew the tablet completely and not to swallow it whole. Serious gastrointestinal complications have been reported with unchewed or incompletely chewed tablets.
Contraindications
Lanthanum Carbonate must not be used by people with a bowel obstruction. This includes ileus and fecal impaction.
Pregnancy & Breastfeeding
Pregnancy: The case reports available on Lanthanum Carbonate in pregnant women don't give enough information to say whether the medicine carries a risk of major birth defects, miscarriage, or other harmful outcomes for the mother or the baby. In a pregnant woman, use a phosphate binder that does not contain Lanthanum.
Lactation: There are no data on whether Lanthanum Carbonate passes into human milk, what effect it has on a breastfed infant, or whether it changes milk production. In a woman who is breastfeeding, use a phosphate binder that does not contain Lanthanum.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: The safety and efficacy of Lanthanum Carbonate in pediatric patients have not been established, so its use in this group is not recommended.
Geriatric use: In the clinical studies of Lanthanum Carbonate, 32% (538) of the patients were over 65 years of age, and 9.3% (159) were over 75. The studies found no overall difference in safety or effectiveness between patients over 65 and younger patients.
Overdose
An overdose of Lanthanum Carbonate causes the same kinds of adverse reactions the medicine can cause at normal doses, such as headache, nausea and vomiting. In clinical trials in healthy adults, people reported gastrointestinal (GI) symptoms with daily doses of up to 6,000 mg/day of Lanthanum Carbonate taken with food.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Lanthanum Carbonate in a cool, dry place where the temperature stays below 30° C, and away from light. Keep it out of the reach of children.
Drug Interactions
Common questions about Lanfos 250 mg
What is Lanfos 250 mg Chewable Tablet?
Lanfos 250 mg Chewable Tablet is a medicine that contains Lanthanum Carbonate. It is made by Beacon Pharmaceuticals PLC. It belongs to the Drugs used in chronic kidney dialysis group of medicines.
What is Lanfos used for?
Lanthanum Carbonate is a phosphate binder. Doctors use it to lower the level of phosphate in the blood (serum phosphate) in patients with end-stage renal disease (ESRD).
What are the side effects of Lanfos?
The most common side effects seen with Lanthanum Carbonate were stomach and bowel problems, such as nausea, vomiting and abdominal pain. These usually eased over time as people kept taking the medicine.
Can I take Lanfos during pregnancy or while breastfeeding?
Pregnancy: The case reports available on Lanthanum Carbonate in pregnant women don't give enough information to say whether the medicine carries a risk of major birth defects, miscarriage, or other harmful outcomes for the mother or the baby. In a pregnant woman, use a phosphate binder that does not contain Lanthanum. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Lanfos?
An overdose of Lanthanum Carbonate causes the same kinds of adverse reactions the medicine can cause at normal doses, such as headache, nausea and vomiting. In clinical trials in healthy adults, people reported gastrointestinal (GI) symptoms with daily doses of up to 6,000 mg/day of Lanthanum Carbonate taken with food. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Lanfos?
Keep Lanthanum Carbonate in a cool, dry place where the temperature stays below 30° C, and away from light. Keep it out of the reach of children.
Can I take other medicines with Lanfos?
Some medicines can interact with Lanthanum Carbonate, for example: Roxadustat, Ciprofloxacin, Magnesium, Levothyroxine Sodium. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Lanfos is already among the lowest-priced brands of Lanthanum Carbonate at this strength.
Do I need a prescription for Lanfos?
Lanfos is a prescription (Rx) medicine. Take it as your doctor advises.