Indications & Uses
Amino Acid + Calcium is used to prevent and treat damage caused by faulty or low protein metabolism in chronic renal insufficiency. It goes with a limited protein intake in the diet of 40 g/day (for adults), so in general it is meant for patients with a glomerular filtration rate (GFR) of 25 mL/minutes.
Pharmacology
This tablet lets the body take in essential amino acids while keeping the intake of amino-nitrogen as low as possible. After absorption, the keto- and hydroxy-analogues are transaminated into the matching essential amino acids. They do this by taking nitrogen from non-essential amino acids, so less urea forms because the amino group is used again. This reduces the build-up of uraemic toxins.
Keto and hydroxy acids do not cause hyperfiltration of the residual nephrons. Supplements that contain ketoacids also have a positive effect on renal hyperphosphataemia and secondary hyperparathyroidism, and renal osteodystrophy may improve as well.
When the tablet is used together with a very low protein diet, nitrogen intake can be reduced. At the same time, it helps prevent the harmful effects of too little dietary protein and malnutrition.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults (70 kg body weight): if your doctor has not prescribed otherwise, take 4 to 8 tablets three times a day during meals. Swallow them whole and don't chew them. Taking the tablets with meals helps them absorb properly and break down into the corresponding amino acids.
Duration of application: these tablets are given as long as the glomerular filtration rate (GFR) is between 5 and about 15 mL/minute. During this time, the diet should also contain 40 g/day of protein or less (adults).
Side Effects
Hypercalcaemia may develop with Amino Acid + Calcium. If it does, the usual advice is to cut down the Vitamin D intake first. If the calcium level stays high, reduce the dose of this tablet, and reduce any other source of calcium too. The serum calcium level should be checked regularly. Make sure the calorie intake is sufficient. No experience has been gained so far with giving this medicine to paediatric patients.
Cautions & Contraindications
Warnings & Precautions
Check the serum calcium level regularly while using Amino Acid + Calcium, and make sure the person gets enough calories. The tablet contains phenylalanine, so take care in people with hereditary phenylketonuria. If aluminium hydroxide is given at the same time, the serum phosphate levels need to be monitored.
Pregnancy & Breastfeeding
There isn't enough data on the use of this Amino Acid + Calcium tablet in pregnant women. Animal studies don't show any direct or indirect harmful effects on pregnancy, on the development of the embryo or foetus, on childbirth, or on development after birth. Even so, caution should be exercised when prescribing it to pregnant women. There is no experience so far with its use during breastfeeding. No case of overdose has been reported.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Amino Acid + Calcium at a temperature no higher than 30° C. Leave the tablets in their original package, and keep the blisters tightly closed so moisture can't get in.
Drug Interactions
Common questions about Ketosteril
What is Ketosteril Tablet?
Ketosteril Tablet is a medicine that contains Amino Acid + Calcium. It is made by Janata Traders. It belongs to the Drugs used in chronic kidney dialysis group of medicines.
What is Ketosteril used for?
Amino Acid + Calcium is used to prevent and treat damage caused by faulty or low protein metabolism in chronic renal insufficiency. It goes with a limited protein intake in the diet of 40 g/day (for adults), so in general it is meant for patients with a glomerular filtration rate (GFR) of 25 mL/minutes.
What are the side effects of Ketosteril?
Hypercalcaemia may develop with Amino Acid + Calcium. If it does, the usual advice is to cut down the Vitamin D intake first.
Can I take Ketosteril during pregnancy or while breastfeeding?
There isn't enough data on the use of this Amino Acid + Calcium tablet in pregnant women. Animal studies don't show any direct or indirect harmful effects on pregnancy, on the development of the embryo or foetus, on childbirth, or on development after birth. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Ketosteril?
Keep Amino Acid + Calcium at a temperature no higher than 30° C. Leave the tablets in their original package, and keep the blisters tightly closed so moisture can't get in.
Can I take other medicines with Ketosteril?
Some medicines can interact with Amino Acid + Calcium, for example: Ciprofloxacin, Iron. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Ketosteril?
Ketosteril is a prescription (Rx) medicine. Take it as your doctor advises.