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Indications & Uses
Insulet N is indicated for:
Pharmacology
Insulin Human is a sterile, clear, colourless solution. It is a fast-acting insulin, and its action lasts a relatively short time compared with other insulins. It may be used together with long-acting insulins.
Insulin lowers blood glucose because it binds to receptors on muscle and fat cells, which helps these cells take up glucose. At the same time, it stops the liver from releasing glucose.
In the blood stream, insulin has a half-life of a few minutes. It does not bind profoundly to plasma proteins.
After a subcutaneous injection, the average action profile is as follows:
Onset of action: within 30 minutes
Peak plasma levels: reached between 1 to 3 hours
Duration of action: approximately 4 to 6 hours
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage is individual, and the physician decides it according to the needs of the patient.
For maintenance therapy in type 1 diabetic patients, the average total daily insulin requirement lies between 0.5 and 1.0 IU/Kg. In pre-pubertal children it usually varies from 0.7 to 1.0 IU/Kg.
The daily insulin requirement may be higher in patients with insulin resistance (for example during puberty in the young, or due to obesity). It may be lower in patients with endogenous insulin production, or during a period of partial remission.
The initial dosage for type 2 diabetic patients is often lower, for example 0.3 to 0.6 IU/Kg/Day. An injection should be followed within 30 minutes by a meal or snack containing carbohydrates.
Side Effects
Most of the side effects seen in patients using Insulin Human [rDNA] depend on the dose, and they come from the pharmacological effect of the insulin itself. As with other insulin products, hypoglycaemia is generally the most frequent unwanted effect. It can happen when the insulin dose is too high for what the body actually needs. Lipodystrophy may develop at the injection site if the injection sites are not rotated within an area. Generalised hypersensitivity can cause a skin rash all over the body, itching, sweating, gastrointestinal upset, angioneurotic oedema, difficulty in breathing, palpitation and a fall in blood pressure. These reactions can be life threatening. Oedema may appear when insulin treatment is started. These symptoms usually pass after a short time.
Cautions & Contraindications
Warnings & Precautions
If the dose of insulin is too low, or if treatment is stopped, hyperglycaemia can develop, especially in type 1 diabetes. In type 1 diabetes, hyperglycaemic events that go untreated will eventually lead to diabetic ketoacidosis, which can be lethal. Hypoglycaemia may occur if the insulin dose is too high for the amount of insulin the body needs. Transferring a patient to another type or brand of insulin should be done under strict medical supervision. A change in strength, brand (manufacturer), type (rapid acting insulin, dual acting insulin, intermediate and long acting insulin etc.), species (animal, human insulin analogue) or method of manufacture (recombinant DNA versus animal source insulin) may mean the dose has to be changed. Before travelling between different time zones, patients should be advised to talk to their doctor. Travel like this may mean they have to take insulin and meals at different times.
Contraindications
Insulin Human [rDNA] should never be given to a patient who has hypoglycaemia, or to anyone who is hypersensitive to human insulin or to any of the excipients in the product.
Pregnancy & Breastfeeding
Insulin Human [rDNA] can be used to treat diabetes during pregnancy without any restriction, because insulin doesn't cross the placental barrier. Poorly controlled diabetes is the real danger. Both hypoglycaemia and hyperglycaemia can happen when diabetes therapy isn't adequate, and either one raises the risk of malformations and death in utero.
Insulin requirements usually fall in the first trimester. They then rise through the second and third trimesters. After delivery, the requirement goes back quickly to what it was before pregnancy.
A nursing mother can take insulin without any risk to her baby. Her insulin dosage, her diet or both may still need to be adjusted.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Diasulin Ns has no specific overdose definitions. Hypoglycaemia can still develop, though, and it may come on in stages. Mild hypoglycaemic episodes can be treated with glucose or sugary products taken by mouth. In a severe episode the patient becomes unconscious. A trained person can then give glucagon (0.5 to 1 mg) intramuscularly or subcutaneously, or a medical professional can give glucose intravenously. Glucose must also be given intravenously if the patient does not respond to glucagon within 10 to 15 minutes. Upon regaining consciousness, the patient is recommended to take oral carbohydrate to prevent a relapse.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Insulin Human [rDNA] in a refrigerator, between 2°C and 8°C. If a preparation has been frozen, don't use it. Leave it in its outer carton so the light stays off it, and keep it away from excessive heat and direct sunlight.
Check the solution before use. If it isn't water-clear and colorless, it should not be used.
A vial that is in use should not be put in the refrigerator. Once you start using it, the vial can be used for up to 6 weeks if it is stored below 25°C, or for 4 weeks if it is stored below 30°C.
Drug Interactions
Common questions about Insulet N 100 IU/ml
What is Insulet N 100 IU/ml SC Injection?
Insulet N 100 IU/ml SC Injection is a medicine that contains Insulin Human [rDNA]. It is made by Aristopharma Limited. It belongs to the Long Acting Insulin group of medicines.
What is Insulet N used for?
Insulet N is used for: Type 2 Diabetes Mellitus, Type 1 Diabetes Mellitus, Diabetes Mellitus.
What are the side effects of Insulet N?
Most of the side effects seen in patients using Insulin Human [rDNA] depend on the dose, and they come from the pharmacological effect of the insulin itself. As with other insulin products, hypoglycaemia is generally the most frequent unwanted effect.
Can I take Insulet N during pregnancy or while breastfeeding?
Insulin Human [rDNA] can be used to treat diabetes during pregnancy without any restriction, because insulin doesn't cross the placental barrier. Poorly controlled diabetes is the real danger. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Insulet N?
Diasulin Ns has no specific overdose definitions. Hypoglycaemia can still develop, though, and it may come on in stages. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Insulet N?
Keep Insulin Human [rDNA] in a refrigerator, between 2°C and 8°C. If a preparation has been frozen, don't use it.
Can I take other medicines with Insulet N?
Some medicines can interact with Insulin Human [rDNA], for example: Danazol, Insulin (Human) 30/70, Octreotide Acetate. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Insulet N?
Insulet N is a prescription (Rx) medicine. Take it as your doctor advises.