Pricing
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All price changes →Indications & Uses
Icosa is indicated for:
Pharmacology
Icosapent Ethyl is an ethyl ester of the omega-3 fatty acid eicosapentaenoic acid (EPA). EPA reduces the synthesis and/or secretion of hepatic very low-density lipoprotein triglycerides (VLDL-TG), and it also improves the clearance of TG from circulating VLDL particles. The possible mechanisms of action include increased p-oxidation, inhibition of acyl-CoA:1,2-diacylglycerol acyltransferase (DGAT), decreased lipogenesis in the liver, and increased plasma lipoprotein lipase activity.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The daily dose of Icosapent Ethyl is 4 grams. This is taken as two 1 gm capsules twice daily with food. Patients should swallow the capsules whole. Don't break open, crush, dissolve or chew Icosapent Ethyl.
Renal impairment: Icosapent ethyl has not been studied in patients with renal impairment.
Hepatic impairment: In patients with hepatic impairment, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels should be monitored periodically during therapy with Icosapent ethyl.
Pediatric use: Safety and effectiveness in pediatric patients have not been established.
Geriatric use: Icosapent ethyl is safe and effective in geriatric patients.
Side Effects
In the cardiovascular outcomes trial, the common side effects of Icosapent Ethyl were musculoskeletal pain, peripheral edema, constipation, gout and atrial fibrillation. In the hypertriglyceridemia trials, the common ones were arthralgia and oropharyngeal pain.
Cautions & Contraindications
Warnings & Precautions
Icosapent Ethyl was linked to a higher risk of atrial fibrillation or atrial flutter needing hospital admission in a double-blind, placebo-controlled trial. Atrial fibrillation was more common in patients who had atrial fibrillation or atrial flutter before. Fish allergy is another concern. The medicine contains ethyl esters of the omega-3 fatty acid eicosapentaenoic acid (EPA), which comes from fish oil. It isn't known whether people with allergies to fish and/or shellfish have a higher risk of an allergic reaction to it. Patients with known hypersensitivity to fish and/or shellfish should be made aware of the potential for allergic reactions. They should stop Icosapent Ethyl and seek medical attention. Bleeding risk was also higher in the same double-blind, placebo-controlled trial. Bleeding happened more often in patients who were also taking antithrombotic medicines such as aspirin, clopidogrel or warfarin.
Contraindications
Icosapent Ethyl must not be given to anyone who is known to be hypersensitive to it, for example someone who has had an anaphylactic reaction to Icosapent Ethyl or to any of its components.
Pregnancy & Breastfeeding
Icosapent Ethyl should be used in pregnancy only when the possible benefit to the mother is greater than the possible risk to the fetus. Omega-3 fatty acids, including EPA, have been found in human milk. Because the nursing infant could be affected, the mother and doctor need to decide whether to stop nursing or stop the medicine, and the decision should take into account how much the mother needs the medicine.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Icosapent Ethyl at a temperature no higher than 25°C, and protect it from light. Keep it out of the reach of children.
Drug Interactions
Common questions about Icosa 1 gm
What is Icosa 1 gm Capsule?
Icosa 1 gm Capsule is a medicine that contains Icosapent Ethyl. It is made by DBL Pharmaceuticals Limited. It belongs to the Anti-anginal & lipid lowering drugs group of medicines.
What is Icosa used for?
Icosa is used for: Angina Pectoris, Myocardial Infarction, Stroke, Diabetes Mellitus.
What are the side effects of Icosa?
In the cardiovascular outcomes trial, the common side effects of Icosapent Ethyl were musculoskeletal pain, peripheral edema, constipation, gout and atrial fibrillation. In the hypertriglyceridemia trials, the common ones were arthralgia and oropharyngeal pain.
Can I take Icosa during pregnancy or while breastfeeding?
Icosapent Ethyl should be used in pregnancy only when the possible benefit to the mother is greater than the possible risk to the fetus. Omega-3 fatty acids, including EPA, have been found in human milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Icosa?
Keep Icosapent Ethyl at a temperature no higher than 25°C, and protect it from light. Keep it out of the reach of children.
Can I take other medicines with Icosa?
Some medicines can interact with Icosapent Ethyl, for example: Omega 3 Fish Oil. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Icosa is already among the lowest-priced brands of Icosapent Ethyl at this strength.
Do I need a prescription for Icosa?
Icosa is a prescription (Rx) medicine. Take it as your doctor advises.