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Same active ingredient — pay up to 1% less
These brands contain the same active ingredient (Lamivudine [For Chronic Hepatitis B]). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Hepavir is indicated for:
Pharmacology
Lamivudine is a synthetic nucleoside analogue. Inside the cell it is phosphorylated to lamivudine triphosphate. The monophosphate form is then built into viral DNA by hepatitis B virus (HBV) polymerase, and this ends the DNA chain. Lamivudine triphosphate also inhibits the RNA and DNA-dependent DNA polymerase activities of HIV-1 reverse transcriptase (RT). It is only a very weak inhibitor of mammalian alpha, beta and gamma-DNA polymerases.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For adults with chronic hepatitis B, the usual oral dose of Lamivudine is 100 mg taken once a day.
Side Effects
Several serious side effects have been reported with Lamivudine used for chronic hepatitis B. These are lactic acidosis and severe hepatomegaly with steatosis, worsening of hepatitis B after treatment stops, pancreatitis, and the emergence of viral mutants that are less susceptible to the drug and so lead to a weaker response to treatment. Other effects that may occur are malaise, fatigue, fever, ENT infections, sore throat, nausea, vomiting, abdominal discomfort, pain, diarrhea, myalgia, arthralgia, headache and skin rashes. Lactic acidosis and severe hepatomegaly with steatosis have been reported with this medicine.
Cautions & Contraindications
Warnings & Precautions
A doctor who has experience in managing chronic hepatitis B should assess the patient before Lamivudine [For Chronic Hepatitis B] is started, and should keep assessing them while the treatment goes on.
Contraindications
Don't give Lamivudine to anyone who is hypersensitive to any of the components of the product.
Pregnancy & Breastfeeding
No adequate and well-controlled study has been done in pregnant women, so Lamivudine should be used in pregnancy only if the expected benefit is greater than the risk. It isn't known whether lamivudine passes into human milk. Because it could cause adverse effects in a nursing infant, mothers who are receiving lamivudine should be told not to breastfeed.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Lamivudine [For Chronic Hepatitis B] doses should be adjusted according to kidney function. The adjustment is based on creatinine clearance (CrCl), as follows:
CrCl 50 ml/min: 100 mg once daily
CrCl 30-49 ml/min: 100 mg first dose, then 50 mg once daily
CrCl 15-29 ml/min: 100 mg first dose, then 25 mg once daily
CrCl 5-14 ml/min: 35 mg first dose, then 15 mg once daily
CrCl <5 ml/min: 35 mg first dose, then 10 mg once daily
Use in children: The safety and efficacy of Lamivudine [For Chronic Hepatitis B] for treating chronic hepatitis B in children have not been established.
Storage
Store Lamivudine below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Hepavir 100 mg
What is Hepavir 100 mg Tablet?
Hepavir 100 mg Tablet is a medicine that contains Lamivudine [For Chronic Hepatitis B]. It is made by Square Pharmaceuticals PLC, Pabna. It belongs to the Hepatic viral infections (Hepatitis B) group of medicines.
What is Hepavir used for?
Hepavir is used for: Inflammation.
What are the side effects of Hepavir?
Several serious side effects have been reported with Lamivudine used for chronic hepatitis B. These are lactic acidosis and severe hepatomegaly with steatosis, worsening of hepatitis B after treatment stops, pancreatitis, and the emergence of viral mutants that are less susceptible to the drug and so lead to a weaker response to treatment.
Can I take Hepavir during pregnancy or while breastfeeding?
No adequate and well-controlled study has been done in pregnant women, so Lamivudine should be used in pregnancy only if the expected benefit is greater than the risk. It isn't known whether lamivudine passes into human milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Hepavir?
Store Lamivudine below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Hepavir?
Some medicines can interact with Lamivudine [For Chronic Hepatitis B], for example: Trimethoprim. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Lamivir by Incepta Pharmaceuticals Ltd. has the same ingredient and strength for ৳25.00 per unit, compared with ৳25.17 for Hepavir. Ask your doctor or pharmacist before switching.
Do I need a prescription for Hepavir?
Hepavir is a prescription (Rx) medicine. Take it as your doctor advises.