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Indications & Uses
Fragmin is indicated for:
Pharmacology
Dalteparin Na is an antithrombotic medicine. It works mainly by boosting the way antithrombin inhibits factor Xa and thrombin. Its effect on factor Xa inhibition is relatively stronger than its effect on prolonging aPTT.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dalteparin Sodium is given by the intravenous route for prophylaxis of clotting in extracorporeal circulation in haemodialysis or haemofiltration. The dose is 30 to 40 U/kg as an IV injection, then 10 to 15 U/kg/hr as an IV infusion. By the subcutaneous route, for venous thromboembolism, the dose is 200 U/kg/day, given as a single dose or in 2 divided doses, in pregnant and high-risk patients. The maximum is 18,000 U/day. For prophylaxis of venous thromboembolism during surgical procedures, the dose depends on the risk. In moderate risk, give 2,500 U 1 to 2 hr pre-op, then 2,500 U once daily for 5 to 7 days or until the patient is fully ambulant. In high risk, give 2,500 U 1 to 2 hr before and 8 to 12 hr after the procedure, then 5,000 U daily. For unstable angina, the dose is 120 U/kg 12 hrly, continued for 5 to 8 days with low-dose aspirin. The maximum here is 10,000 U 12 hrly.
Side Effects
Dalteparin Sodium can raise the serum transaminase levels (AST and ALT). Allergic reactions are possible too, such as pruritus, rash, fever, a reaction at the injection site and bullous eruption. Some people also have pain at the injection site. More serious effects include epidural or spinal haematomas, which may result in permanent paralysis, as well as severe haemorrhage and thrombocytopenia.
Cautions & Contraindications
Warnings & Precautions
Take care with Dalteparin Sodium in patients who have a higher risk of bleeding. This includes people after surgery or trauma, and those with haemorrhagic stroke, thrombocytopenia or defective platelet function, uncontrolled HTN, or hypertensive or diabetic retinopathy. Spinal or epidural haematomas are more likely in patients having neuraxial anaesth or a spinal puncture, especially when indwelling epidural catheters are used after the operation. Use caution too in hepatic and renal impairment, and in pregnancy and lactation.
Contraindications
Dalteparin Sodium must not be used in people with hypersensitivity, active major bleeding or severe coagulation disorders. It is also not for use with lumbar puncture, sympathetic block, or surgery on the brain, spinal cord, eye or ear, or in severe hypertension.
Pregnancy & Breastfeeding
Dalteparin Sodium is Pregnancy Category B. This means one of two things. Either animal-reproduction studies have not shown a foetal risk, but there are no controlled studies in pregnant women. Or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester, and there is no evidence of a risk in later trimesters.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
An overdose of dalteparin sodium can cause bleeding complications. To manage it, give protamine sulfate by slow IV injection at a dose of 1 mg for every 100 anti-Xa U of dalteparin Na given.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Drug Interactions
Common questions about Fragmin 7500 IU/0.3 ml
What is Fragmin 7500 IU/0.3 ml SC Injection?
Fragmin 7500 IU/0.3 ml SC Injection is a medicine that contains Dalteparin Sodium. It is made by Janata Traders. It belongs to the Parenteral anti-coagulants group of medicines.
What is Fragmin used for?
Fragmin is used for: Angina Pectoris, Deep Vein Thrombosis.
What are the side effects of Fragmin?
Dalteparin Sodium can raise the serum transaminase levels (AST and ALT). Allergic reactions are possible too, such as pruritus, rash, fever, a reaction at the injection site and bullous eruption.
Can I take Fragmin during pregnancy or while breastfeeding?
Dalteparin Sodium is Pregnancy Category B. This means one of two things. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Fragmin?
An overdose of dalteparin sodium can cause bleeding complications. To manage it, give protamine sulfate by slow IV injection at a dose of 1 mg for every 100 anti-Xa U of dalteparin Na given. In an emergency call 999 or go to the nearest hospital emergency department.
Can I take other medicines with Fragmin?
Some medicines can interact with Dalteparin Sodium, for example: Sulfinpyrazone, Dipyridamole, Aspirin, Tetracycline Hydrochloride, Ascorbic Acid 25 gm/100 gm. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Fragmin?
Fragmin is a prescription (Rx) medicine. Take it as your doctor advises.