Indications & Uses
Sodium Picosulfate, Magnesium Oxide and Anhydrous Citric Acid, given as an oral solution or as a powder made up into an oral solution, is used to clean out the colon before a colonoscopy. It can be given to adults and to children aged 9 years and above. It is also used before a barium enema, an x-ray exam or surgical procedures that need a clean colon.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
There are two dosing regimens for Sodium Picosulfate + Magnesium Oxide + Citric Acid, and each one needs two separate dosing times.
Split-Dose Dosing Regimen (Preferred Method): This is the preferred dosing method. Tell patients to take two separate doses with fluids, as follows. The first dose (1 bottle/1 sachet) is taken in the evening before the colonoscopy (e.g., 5:00 to 9:00 PM). Afterwards, patients drink 1200 ml of clear liquids (5x 240 ml drinks, using the provided measuring cup) before bed, finishing them within 5 hours. The second dose (1 bottle/1 sachet) is taken the next day, about 5 hours before the colonoscopy, followed by at least 720 ml (3x240 ml) of clear liquids. These should be finished within the next 5 hours, but at least 2 hours before the time of the colonoscopy.
Day-Before Dosing Regimen (Alternative Method): This is the alternative dosing method, for patients in whom Split-Dosing is inappropriate. Again, tell patients to take two separate doses with fluids. The first dose (1 bottle/1 sachet) is taken in the afternoon or early evening (e.g., 4:00 to 6:00 PM) before the colonoscopy. It is followed by 1200 ml (5x 240 ml, using the provided measuring cup) of clear liquids before the next dose, and these are finished within 5 hours. The second dose (1 bottle/1 sachet) is taken about 6 hours later, in the late evening (e.g., 10:00 PM to 12:00 AM) of the night before the colonoscopy. Patients then drink at least 720 ml (3x240 ml) of clear liquids before bed, again finishing them within 5 hours.
In both regimens, patients must drink extra fluids after every dose. Tell them to take only clear liquids (no solid food or milk) on the day before the colonoscopy, right up until 2 hours before the time of the colonoscopy. If a patient has severe bloating, distention or abdominal pain after the first dose, the second dose should be delayed until the symptoms resolve.
Side Effects
The most common side effects of Sodium Picosulfate + Magnesium Oxide + Citric Acid, seen in more than 1% of people, are nausea, headache and vomiting. Abdominal bloating, distension, pain or cramping, and watery diarrhea that didn't need any treatment were not recorded.
Cautions & Contraindications
Warnings & Precautions
Serious Fluid and Serum Chemistry Abnormalities Advise patients to drink enough fluid before, during and after using Sodium Picosulfate + Magnesium Oxide + Citric Acid. Take care when replacing fluids in patients with congestive heart failure. If a patient has significant vomiting or signs of dehydration, including signs of orthostatic hypotension, after taking this solution, consider doing post-colonoscopy lab tests (electrolytes, creatinine and BUN) and treat accordingly. Fluid and electrolyte disturbances can lead to serious adverse events, including cardiac arrhythmias, seizures and renal impairment. Any fluid and electrolyte abnormalities should be corrected before treatment with this solution. Generalized tonic-clonic seizures have been reported with bowel preparation products, even in patients with no prior history of seizures. These cases were linked with electrolyte abnormalities (e.g. hyponatremia, hypokalemia, hypocalcemia and hypomagnesemia) and low serum osmolality. The neurologic abnormalities resolved once the fluid and electrolyte abnormalities were corrected.
Contraindications
Sodium Picosulfate + Magnesium Oxide + Citric Acid solution must not be used in people with severely reduced kidney function (creatinine clearance less than 30 ml/minute), because magnesium may build up in the body. It must also not be used in these conditions: gastrointestinal obstruction or ileus, bowel perforation, toxic colitis or toxic megacolon, and gastric retention. It is also contraindicated in anyone with an allergy to any of the ingredients in this solution.
Pregnancy & Breastfeeding
Sodium Picosulfate + Magnesium Oxide + Citric Acid is Pregnancy Category B. No adequate and well-controlled studies have been done in pregnant women. Animal reproduction studies don't always predict how humans will respond, so this solution should be used during pregnancy only if clearly needed.
It isn't known whether this medicine passes into human milk. Many medicines do pass into milk, so caution should be exercised when the solution is given to a nursing woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric Use
The safety and effectiveness of this Sodium Picosulfate + Magnesium Oxide + Citric Acid oral solution in pediatric patients has not been established.
Renal Insufficiency
Take extra care in patients with impaired renal function, and in patients who are also taking medicines that may affect renal function (such as diuretics, angiotensin-converting enzyme inhibitors or angiotensin receptor blockers). These patients should be made aware of the importance of adequate hydration before, during and after use of this oral solution. In patients with severely reduced renal function (creatinine clearance <30 mL/min), magnesium may accumulate in plasma.
Storage
Store at a temperature between 15°C and 30°C.
Drug Interactions
Common questions about EzyColon 10 mg+3.5 gm+12 gm
What is EzyColon 10 mg+3.5 gm+12 gm Oral Powder?
EzyColon 10 mg+3.5 gm+12 gm Oral Powder is a medicine that contains Sodium Picosulfate + Magnesium Oxide + Citric Acid. It is made by Pharmasia Ltd. It belongs to the Enema & bowel cleansing solution group of medicines.
What is EzyColon used for?
Sodium Picosulfate, Magnesium Oxide and Anhydrous Citric Acid, given as an oral solution or as a powder made up into an oral solution, is used to clean out the colon before a colonoscopy. It can be given to adults and to children aged 9 years and above.
What are the side effects of EzyColon?
The most common side effects of Sodium Picosulfate + Magnesium Oxide + Citric Acid, seen in more than 1% of people, are nausea, headache and vomiting. Abdominal bloating, distension, pain or cramping, and watery diarrhea that didn't need any treatment were not recorded.
Can I take EzyColon during pregnancy or while breastfeeding?
Sodium Picosulfate + Magnesium Oxide + Citric Acid is Pregnancy Category B. No adequate and well-controlled studies have been done in pregnant women. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store EzyColon?
Store at a temperature between 15°C and 30°C.
Can I take other medicines with EzyColon?
Some medicines can interact with Sodium Picosulfate + Magnesium Oxide + Citric Acid, for example: Carbamazepine, Digoxin, Iron, Magnesium, Penicillamine, Chlorpromazine Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for EzyColon?
EzyColon is a prescription (Rx) medicine. Take it as your doctor advises.