Indications & Uses
Dotin 0.5 is indicated for:
Pharmacology
Dotinurad is a selective inhibitor of URAT1, a transporter that takes urate back into the body from the kidney. By blocking URAT1, dotinurad reduces urate reabsorption, so more urate leaves in the urine and serum urate levels fall.
It also has only weak effects on ABCG2, OAT1 and OAT3 (apart from URAT143,44). Because of this, it is expected to lower serum uric acid effectively without interfering with uric acid secretion through these transporters. Dotinurad is therefore called a selective urate reabsorption inhibitor (SURI). Its high selectivity for URAT1 means it blocks the reabsorption pathway mediated by URAT1 and leaves the secretion pathway mediated by ABCG2, OAT1 and OAT3 alone.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual adult dose of Dotinurad is 0.5 mg, taken by mouth once a day. After that, the doctor raises the dose step by step as needed, checking the blood uric acid level along the way. The maintenance dose is usually 2 mg once a day. It may be adjusted according to the patient's condition, but the maximum is 4 mg once a day.
Precautions related to dosage and administration
In the early stages of treatment with urate-lowering drugs, a rapid fall in blood uric acid can bring on gouty arthritis (a gout attack). For this reason the dose is increased gradually, to 1 mg once a day after 2 weeks and to 2 mg once a day after 6 weeks. Patients should be watched carefully after each increase in dose.
Missing dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed one and carry on with your regular schedule. Never take two doses at once. Don't stop taking this medicine unless your doctor advises it.
Overdose
If you accidentally take too much, consult your doctor or pharmacist.
Side Effects
The side effects people report most often with Dotinurad are gouty arthritis and limb discomfort, and these were seen in 1% to less than 5% of patients. Several others have been reported in less than 1% of patients: loose stools, increased y-GTP, arthralgia, kidney stones, nephrocalcinosis, increased urinary y2 macroglobulin, increased blood creatinine, increased urine albumin/creatinine ratio and positive urine albumin.
Cautions & Contraindications
Warnings & Precautions
Gouty arthritis: Dotinurad lowers the uric acid level in the blood, and lowering it just as a gout attack begins may make the gouty arthritis worse. So if a patient already has a gout attack before treatment, don't start the medicine until the symptoms settle. If an attack comes on while the patient is taking it, continue without changing the dose. Colchicine, non-steroidal anti-inflammatory drugs, corticosteroids and similar medicines may be given together with it, depending on the symptoms. Patients with urolithiasis: Don't give it unless treatment cannot be avoided. The medicine increases the amount of uric acid passed in the urine, and this action may make the symptoms of urinary stones worse. Patients with renal impairment: Consider treatment with other medicines. Dotinurad works in the renal proximal tubule, so how well it works may fall depending on the degree of kidney dysfunction. It should be avoided in patients with oliguria or anuria, because no benefit can be expected. Patients with hepatic impairment: Follow the patient carefully. Serious liver damage has been seen with other uricosuric agents.
Contraindications
Dotinurad must not be given to anyone who is known to be allergic to the medicine or to any of its components.
Pregnancy & Breastfeeding
Dotinurad should be used in pregnancy only when the doctor judges that the benefit to the mother outweighs the risk. The medicine passes into breast milk, so talk to your doctor before you breastfeed.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Dotinurad in a dry place below 30°C, away from light. Keep it out of the reach of children.
Drug Interactions
Common questions about Dotin 0.5 500 mcg
What is Dotin 0.5 500 mcg Tablet?
Dotin 0.5 500 mcg Tablet is a medicine that contains Dotinurad. It is made by General Pharmaceuticals Ltd. It belongs to the Drugs used in Gout group of medicines.
What is Dotin 0.5 used for?
Dotin 0.5 is used for: Gout.
What are the side effects of Dotin 0.5?
The side effects people report most often with Dotinurad are gouty arthritis and limb discomfort, and these were seen in 1% to less than 5% of patients. Several others have been reported in less than 1% of patients: loose stools, increased y-GTP, arthralgia, kidney stones, nephrocalcinosis, increased urinary y2 macroglobulin, increased blood creatinine, increased urine albumin/creatinine ratio and positive urine albumin.
Can I take Dotin 0.5 during pregnancy or while breastfeeding?
Dotinurad should be used in pregnancy only when the doctor judges that the benefit to the mother outweighs the risk. The medicine passes into breast milk, so talk to your doctor before you breastfeed. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Dotin 0.5?
Keep Dotinurad in a dry place below 30°C, away from light. Keep it out of the reach of children.
Can I take other medicines with Dotin 0.5?
Some medicines can interact with Dotinurad, for example: Aspirin, Pyrazinamide, Salicylic Acid. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Dotin 0.5?
Dotin 0.5 is a prescription (Rx) medicine. Take it as your doctor advises.