Pricing
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All price changes →Indications & Uses
Amino acids, glucose and electrolytes is given as a source of all three in adults and children who need nutrition through a drip into the vein (IV nutrition). It suits patients whose amino acid needs are at the basal level.
Pharmacology
A crystalline amino acid solution supplies crystalline amino acids to support protein synthesis and wound healing, and to slow down the rate at which the body breaks down its own protein (endogenous protein catabolism). When amino acids are given through a central venous infusion together with concentrated dextrose, electrolytes, vitamins, trace metals and ancillary fat supplements, this makes up total parenteral nutrition (TPN). Amino acids can also be given through a peripheral vein, with dextrose and maintenance electrolytes.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For adults, the dose of Amino acids, Glucose & Electrolytes depends on the nitrogen needed to maintain body protein mass, and that depends on the patient's condition (nutritional state and degree of metabolic stress). The requirement is 0.10 to 0.15 g nitrogen/kg/day when there is no metabolic stress or only minor stress and the nutritional state is normal. It is 0.15 to 0.20 g nitrogen/kg/day with moderate metabolic stress, with or without malnutrition. In severe catabolism, as in burns, sepsis and trauma, it goes up to 0.20 to 0.25 g nitrogen/kg/day. The dosage range of 0.10 to 0.25 g nitrogen/kg/day corresponds to 11 to 27 ml/kg/day. In obese patients, the dose should be based on the estimated ideal weight.
Depending on the patient's requirements, 1000 to 2000 ml may be infused intravenously per 24 hours. Amino acids, Glucose & Electrolytes should be infused slowly, at a rate not exceeding 500 ml in 3 hours, which corresponds to approximately 1.4 to 2.8 ml (30 to 60 drops) per minute.
For infants and children, a maximal rate of infusion of 30 ml/kg body weight/day is recommended, with a step-wise increase in the rate of administration during the first week of treatment.
Side Effects
Amino acids, Glucose & Electrolytes is usually well tolerated, and nausea is rare. If the solution is infused faster than the recommended maximal rate, vomiting, flushing and sweating have been seen. Some people have had a temporary rise in liver tests during intravenous nutrition. The reasons aren't clear at present. The underlying disease has been suggested as one cause, and so have the components of the feeding regimen and the amounts given. Hypersensitivity reactions have also been reported. Like all hypertonic infusion solutions, this one can cause thrombophlebitis when peripheral veins are used. Infusing 10% fat emulsion at the same time may reduce how often this happens.
Cautions & Contraindications
Warnings & Precautions
Hyperphenylalaninemia has been seen in severely ill, premature infants. For these babies, the phenylalanine level should be monitored and the infusion rate adjusted as needed. Amino acids, Glucose & Electrolytes should be used with caution in patients with diabetes mellitus, severe heart failure, or impaired renal function combined with fluid restriction or oliguria/anuria of other origin. If a patient has hyperglycemia, exogenous insulin might be necessary. Don't use the solution if it looks turbid or contains particles. Discard any unused portion.
Contraindications
Doctors should not give this preparation of amino acids, glucose and electrolytes to patients with inborn errors of amino acids metabolism, severe liver damage, or severe uremia when dialysis facilities are not available. Because it contains glucose, it is also contraindicated in patients with hyperosmolar nonketotic diabetic coma. And it must not be used in anyone with known hypersensitivity to any of its ingredients.
Pregnancy & Breastfeeding
Amino acid solution has been given safely and successfully to pregnant women, and this has been reported in humans. No animal reproduction studies have been carried out with the 7% amino acid IV infusion with 10% glucose & electrolytes.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep this amino acids, glucose and electrolytes preparation away from light, at a temperature between 15°C and 25°C. Don't let it freeze. Always keep it out of the reach of children.
Common questions about Clinosol Gold 7%+10%
What is Clinosol Gold 7%+10% IV Infusion?
Clinosol Gold 7%+10% IV Infusion is a medicine that contains Amino acids, Glucose & Electrolytes. It is made by Opsonin Pharma Limited. It belongs to the Parenteral nutritional preparations group of medicines.
What is Clinosol Gold used for?
Amino acids, glucose and electrolytes is given as a source of all three in adults and children who need nutrition through a drip into the vein (IV nutrition). It suits patients whose amino acid needs are at the basal level.
What are the side effects of Clinosol Gold?
Amino acids, Glucose & Electrolytes is usually well tolerated, and nausea is rare. If the solution is infused faster than the recommended maximal rate, vomiting, flushing and sweating have been seen.
Can I take Clinosol Gold during pregnancy or while breastfeeding?
Amino acid solution has been given safely and successfully to pregnant women, and this has been reported in humans. No animal reproduction studies have been carried out with the 7% amino acid IV infusion with 10% glucose & electrolytes. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Clinosol Gold?
Keep this amino acids, glucose and electrolytes preparation away from light, at a temperature between 15°C and 25°C. Don't let it freeze.
Do I need a prescription for Clinosol Gold?
Clinosol Gold is a prescription (Rx) medicine. Take it as your doctor advises.