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Indications & Uses
Pharmacology
Cefpodoxime proxetil is an oral 3rd generation cephalosporin. It is stable against beta lactamases and works against both Gram negative and Gram positive bacteria. Doctors can use it to treat infections before the infecting organism has been identified. Cefpodoxime proxetil is a prodrug, and its active metabolite is Cefpodoxime. About 29 to 33% of Cefpodoxime is passed out unchanged in the urine within 12 hours.
Cefpodoxime is indicated for patients infected with susceptible strains of microorganisms, which include a wide range of gram-positive and gram-negative bacteria. Because it is highly stable in the presence of the β-lactamase enzyme, it is more effective against gram-positive bacteria than other 3rd generation oral cephalosporins.
The susceptible gram-positive bacteria include S. aureus (including penicillinase producing strains), S. saprophyticus, S. pneumoniae, S. pyogenes, S. agalactiae and P. magnus. The susceptible gram-negative bacteria include E. coli, K. pneumoniae, H. influenzae (including β-lactamase producer and Ampicillin resistant strains), M. catarrhalis, N. gonorrhoeae (including penicillinase producing strains), P. mirabilis, C. diversus, H. parainfluenzae, K. oxytoca, P. vulgaris and P. rettgeri.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults and adolescents (13 years and older)
The dose of Cefpodoxime Proxetil depends on the infection being treated. For pharyngitis/tonsillitis, it is 100 mg 12 hourly for 5 to 10 days. Acute maxillary sinusitis needs 200 mg 12 hourly for 10 days, and community-acquired pneumonia needs 200 mg 12 hourly for 14 days. For acute bacterial exacerbations of chronic bronchitis, the dose is 200 mg 12 hourly for 10 days. Skin and skin structure infections need 400 mg 12 hourly for 7 to 14 days. Uncomplicated urinary tract infection is treated with 100 mg 12 hourly for 7 days. Uncomplicated gonorrhea and rectal gonococcal infections in women are each treated with a single dose of 200 mg.
Infants and pediatric patients (2 months to 12 years)
For acute otitis media, the dose is 5 mg/kg body weight 12 hourly for 5 days. Pharyngitis/tonsillitis is treated with 5 mg/kg body weight 12 hourly for 5 to 10 days, and acute maxillary sinusitis with 5 mg/kg body weight 12 hourly for 10 days.
Patients with renal dysfunction
In severe renal impairment (creatinine clearance <30 ml/min), the dosing interval should be increased to 24 hourly.
Patients with liver cirrhosis
The pharmacokinetics of Cefpodoxime Proxetil in cirrhotic patients are similar to those in healthy subjects, so dose adjustment is not necessary in this population.
Side Effects
Cefpodoxime Proxetil causes very few side effects. The ones that can happen include diarrhea, nausea, fungal infection of the skin and vagina, abdominal pain, headache, chest pain, myalgia, dyspepsia, dizziness, vertigo and cough, among others. Fungal skin rash is seen more often in children than in adults.
Cautions & Contraindications
Warnings & Precautions
If a patient's urine output is reduced, either for a short time or continuously, because of renal insufficiency, the total daily dose of Cefpodoxime Proxetil should be lowered. Like other cephalosporins, it should be given with caution to patients who are also taking potent diuretics. Using Cefpodoxime Proxetil for a long time, as with other broad spectrum antibiotics, may lead to overgrowth of non-susceptible organisms. So the patient's condition needs to be evaluated again and again during treatment.
Contraindications
Cefpodoxime Proxetil should not be given to anyone who is known to be allergic to Cefpodoxime or to any other antibiotic in the cephalosporin group.
Pregnancy & Breastfeeding
In animal studies, Cefpodoxime was not teratogenic and did not kill the embryo. But there is no adequate, well-controlled study of Cefpodoxime Proxetil in pregnant women, so it should be used during pregnancy only if it is clearly needed. Cefpodoxime passes into human milk. Because of this, a decision should be made either to stop breastfeeding or to stop the medicine.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Cefpodoxime Proxetil in a dry place, away from light and heat. Keep it out of the reach of children.
Drug Interactions
Common questions about Cefomin 40 mg/5 ml
What is Cefomin 40 mg/5 ml Powder For Suspension?
Cefomin 40 mg/5 ml Powder For Suspension is a medicine that contains Cefpodoxime Proxetil. It is made by Popular Pharmaceuticals PLC. It belongs to the Third generation cephalosporins group of medicines.
What is Cefomin used for?
Cefomin is used for: Chronic Obstructive Pulmonary Disease, Pneumonia, Bronchitis, Sinusitis, Pharyngitis, Tonsillitis, Skin and Soft Tissue Infection, Viral Infection, Otitis Media.
What are the side effects of Cefomin?
Cefpodoxime Proxetil causes very few side effects. The ones that can happen include diarrhea, nausea, fungal infection of the skin and vagina, abdominal pain, headache, chest pain, myalgia, dyspepsia, dizziness, vertigo and cough, among others.
Can I take Cefomin during pregnancy or while breastfeeding?
In animal studies, Cefpodoxime was not teratogenic and did not kill the embryo. But there is no adequate, well-controlled study of Cefpodoxime Proxetil in pregnant women, so it should be used during pregnancy only if it is clearly needed. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Cefomin?
Store Cefpodoxime Proxetil in a dry place, away from light and heat. Keep it out of the reach of children.
Can I take other medicines with Cefomin?
Some medicines can interact with Cefpodoxime Proxetil, for example: Sodium Bicarbonate, Cefpodoxime. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Cefomin?
Cefomin is a prescription (Rx) medicine. Take it as your doctor advises.