Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →Indications & Uses
Bestron is indicated for:
Pharmacology
Conjugated Estrogens and Bazedoxifene work by binding to the estrogen receptors (ER) α and β and activating them. Bazedoxifene is an estrogen agonist / antagonist. That means it acts as an agonist in some estrogen-sensitive tissues and as an antagonist in others (the uterus, for example).
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Take Conjugated Estrogen + Bazedoxifene once daily. You can take it with or without food, and the tablets should be swallowed whole.
Women using Conjugated Estrogen + Bazedoxifene to prevent postmenopausal osteoporosis should add supplemental calcium and/or vitamin-D to their diet if their daily intake is inadequate.
Use in Children: Conjugated Estrogen + Bazedoxifene is not indicated for use in children.
Side Effects
Conjugated Estrogen + Bazedoxifene can cause high blood pressure, blood clots, liver problems, thyroid problems, fluid retention, hypocalcemia and dementia. Other effects reported are breast lumps, unusual vaginal bleeding, severe headache, muscle spasms, weakness and fatigue, nausea, diarrhea, throat pain and dizziness, among others.
Cautions & Contraindications
Warnings & Precautions
Conjugated Estrogen + Bazedoxifene, like other estrogen therapy, shouldn't be used to prevent cardiovascular disease or dementia. Women who still have a uterus face a higher risk of endometrial cancer if they use unopposed estrogens.
Contraindications
Conjugated Estrogen + Bazedoxifene must not be given to women with undiagnosed abnormal uterine bleeding, or with known, suspected or past breast cancer. It is also contraindicated in known or suspected estrogen-dependent neoplasia, and in active deep venous thrombosis, pulmonary embolism, or a history of these conditions. Women with active arterial thromboembolic disease should not take it either. The same applies to anyone with hypersensitivity (for example, anaphylaxis or angioedema) to estrogens, bazedoxifene or any of the ingredients, and to women with known hepatic impairment or other known thrombophilic disorders.
Pregnancy & Breastfeeding
Conjugated Estrogen + Bazedoxifene is Pregnancy Category X. Women who are pregnant, or who may become pregnant, must not use it.
Women who are breastfeeding should not use Conjugated Estrogen + Bazedoxifene either. It isn't known whether the drug passes into human milk. Estrogen given to nursing mothers has been shown to reduce both the quantity and the quality of the milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
If someone takes too much Conjugated Estrogen + Bazedoxifene, there is no specific antidote, so treatment is based on the symptoms. Overdose of products that contain estrogen may cause nausea, vomiting, breast tenderness, dizziness, abdominal pain and fatigue. Withdrawal bleeding may also occur.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Conjugated Estrogen + Bazedoxifene out of the reach of children. Don't store it above 30°C, and keep it away from light. Once you open the foil pouch, use the product within 60 days.
Common questions about Bestron 0.45 mg+20 mg
What is Bestron 0.45 mg+20 mg Tablet?
Bestron 0.45 mg+20 mg Tablet is a medicine that contains Conjugated Estrogen + Bazedoxifene. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Female Sex hormones group of medicines.
What is Bestron used for?
Bestron is used for: Osteoporosis.
What are the side effects of Bestron?
Conjugated Estrogen + Bazedoxifene can cause high blood pressure, blood clots, liver problems, thyroid problems, fluid retention, hypocalcemia and dementia. Other effects reported are breast lumps, unusual vaginal bleeding, severe headache, muscle spasms, weakness and fatigue, nausea, diarrhea, throat pain and dizziness, among others.
Can I take Bestron during pregnancy or while breastfeeding?
Conjugated Estrogen + Bazedoxifene is Pregnancy Category X. Women who are pregnant, or who may become pregnant, must not use it. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Bestron?
If someone takes too much Conjugated Estrogen + Bazedoxifene, there is no specific antidote, so treatment is based on the symptoms. Overdose of products that contain estrogen may cause nausea, vomiting, breast tenderness, dizziness, abdominal pain and fatigue. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Bestron?
Keep Conjugated Estrogen + Bazedoxifene out of the reach of children. Don't store it above 30°C, and keep it away from light.
Is there a cheaper medicine with the same ingredient?
Bestron is already among the lowest-priced brands of Conjugated Estrogen + Bazedoxifene at this strength.
Do I need a prescription for Bestron?
Bestron is a prescription (Rx) medicine. Take it as your doctor advises.