Pricing
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All price changes →Indications & Uses
Benoxiclin is indicated for:
Pharmacology
Clindamycin stops bacteria from making protein. It binds to the 23S RNA of the 50S subunit of the bacterial ribosome, and this interferes with both the assembly of the ribosome and the translation process. The molecular mechanism is thought to come from the three-dimensional structure of clindamycin, which closely resembles the 3'-ends of L-Pro-Met-tRNA and deacylated-tRNA during the peptide elongation cycle. Because it acts as a structural analog of these tRNA molecules, clindamycin impairs peptide chain initiation and may stimulate dissociation of peptidyl-tRNA from bacterial ribosomes. In benzoyl peroxide, the peroxide bond is cleaved to form 2 benzoyloxy radicals.1 These radicals interact nonspecifically with bacterial proteins, interfering with their function and with the survival of the bacteria. Over time, the free radical interactions with bacterial proteins lead to decreased keratin and sebum around follicles. Benzoyl peroxide can also increase the turnover rate of epithelial cells, which leads to skin peeling and breaks down comedones.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults and adolescents aged 12 years and above should apply this clindamycin and benzoyl peroxide gel once a day, in the evening, to the whole affected area. Patients should know that putting on more gel won't make it work better, but it may raise the risk of skin irritation. If the skin becomes very dry or starts peeling, the gel should be applied less often, or stopped for a short time.
An effect on inflammatory and non-inflammatory lesions may be seen as early as week 2 to 5 of treatment. The safety and efficacy of this gel have not been studied beyond 12 weeks in acne vulgaris clinical trials, so treatment should not go beyond 12 weeks of continuous use.
Paediatric population: the safety and efficacy of this gel have not been established in children under 12 years of age, so it is not recommended for them.
Elderly patients: no specific recommendations.
The gel should be applied in a thin film after washing the skin gently with a mild cleanser and drying it fully. If the gel does not rub into the skin easily, too much is being applied. Wash your hands after application.
Side Effects
Side-effect information is not available for this brand yet.
Cautions & Contraindications
Warnings & Precautions
Keep Benzoyl Peroxide 5% & Clindamycin 1% gel away from the mouth, eyes, lips and other mucous membranes, and away from irritated or broken skin. Use it with caution on sensitive areas of skin. If the gel touches any of these by accident, rinse well with water. Use the gel with caution in patients with a history of regional enteritis or ulcerative colitis, or a history of antibiotic-associated colitis. Be careful in atopic patients too, because further drying of the skin may occur. During the first weeks of treatment, most patients will have more peeling and reddening. Depending on how severe these effects are, the patient can use a non-comedogenic moisturiser, reduce how often the gel is applied for a while, or stop it for a while. Efficacy has not been established for application less often than once daily, however. If other topical acne treatments are used at the same time, take care. The irritation can add up and sometimes becomes severe, especially with peeling, desquamating or abrasive agents. If severe local irritation occurs (e.g. severe erythema, severe dryness and itching, severe stinging/burning), stop the gel. Benzoyl peroxide may make the skin more sensitive to sunlight. So sunlamps should not be used, and deliberate or prolonged sun exposure should be avoided or kept to a minimum. If strong sunlight can't be avoided, the patient should use a sunscreen and wear protective clothing. Any sunburn should clear up before the gel is used. If diarrhoea is prolonged or significant, or the patient gets abdominal cramps, stop treatment immediately, as these symptoms may point to antibiotic-associated colitis. Suitable diagnostic methods should be used, such as determination of Clostridium difficile and toxin and, if necessary, colonoscopy, and treatment options for colitis should be considered. The product may bleach hair or coloured fabrics, so avoid contact with hair, fabrics, furniture or carpeting. Resistance to clindamycin: patients who have recently used systemic or topical clindamycin or erythromycin are more likely to already carry anti-microbial resistant Propionibacterium acnes and commensal flora. Cross-resistance: with antibiotic monotherapy, cross-resistance may occur with other antibiotics such as lincomycin and erythromycin. Interaction with other medicinal products and other forms of interaction: no formal drug-drug interaction studies have been done with this gel. Use caution with concomitant topical antibiotics, medicated or abrasive soaps and cleansers, soaps and cosmetics with a strong drying effect, and products with high concentrations of alcohol and/or astringents, as a cumulative irritant effect may occur. The gel should not be used together with erythromycin-containing products, because of possible antagonism to the clindamycin component. Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents, so caution should be exercised if they are used together. Avoid applying the gel at the same time as tretinoin, isotretinoin and tazarotene, since benzoyl peroxide may reduce their efficacy and increase irritation. If combination treatment is required, apply the products at different times of the day (e.g. one in the morning and the other in the evening). Using topical benzoyl peroxide-containing preparations together with topical sulfonamide-containing products may cause skin and facial hair to change colour temporarily (yellow/orange).
Contraindications
Don't use Benzoyl Peroxide 5% & Clindamycin 1% gel if the patient is known to be hypersensitive to clindamycin, lincomycin or benzoyl peroxide, or to any of the excipients.
Pregnancy & Breastfeeding
Pregnancy: There isn't enough data on the use of Benzoyl Peroxide 5% & Clindamycin 1% gel in pregnant women. No animal reproductive or developmental studies have been done with this gel or with benzoyl peroxide. Data on clindamycin and benzoyl peroxide used alone in pregnant women are limited. A small number of pregnancies exposed to clindamycin in the first trimester show no adverse effects of clindamycin on the pregnancy or on the health of the foetus or new-born child. Reproduction studies in rats and mice, using subcutaneous and oral doses of clindamycin, found no evidence of impaired fertility or harm to the foetus from clindamycin. The safety of Benzoyl Peroxide 5% & Clindamycin 1% gel in human pregnancy has not been established. So the gel should be prescribed to pregnant women only after the physician in charge has carefully weighed the risk against the benefit.
Breastfeeding: Benzoyl Peroxide 5% & Clindamycin 1% gel has not been studied during breastfeeding. Clindamycin and benzoyl peroxide are absorbed through the skin only in low amounts, but it is not known whether either one passes into human milk after the gel is used. Clindamycin has been reported to appear in breast milk after oral and parenteral use. For this reason, the gel should be used during lactation only if the expected benefit justifies the potential risk to the infant. The gel should not be applied to the breast area, so that the infant does not swallow it by accident.
Fertility: There are no data on the effect of Benzoyl Peroxide 5% & Clindamycin 1% gel on fertility in humans.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Using too much Benzoyl Peroxide 5% & Clindamycin 1% gel can cause severe irritation. If that happens, stop using the gel and wait until the skin has recovered.
Benzoyl peroxide applied to the skin is not usually absorbed in enough amounts to cause effects in the rest of the body. Clindamycin is different. If too much is applied, enough can be absorbed to produce effects in the body as a whole.
If someone swallows the gel by accident, they may get gastrointestinal side effects similar to those seen with clindamycin taken by mouth or given by injection.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Clindamycin + Benzoyl peroxide in a refrigerator at 2°-8°C, and don't let it freeze. Once it has been dispensed, don't store it above 25°C.
Drug Interactions
Common questions about Benoxiclin 1%+5%
What is Benoxiclin 1%+5% Topical Gel?
Benoxiclin 1%+5% Topical Gel is a medicine that contains Clindamycin + Benzoyl peroxide. It is made by Unimed Unihealth Pharmaceuticals Ltd. It belongs to the Benzoyl peroxide group of medicines.
What is Benoxiclin used for?
Benoxiclin is used for: Acne Vulgaris.
Can I take Benoxiclin during pregnancy or while breastfeeding?
Pregnancy: There isn't enough data on the use of Benzoyl Peroxide 5% & Clindamycin 1% gel in pregnant women. No animal reproductive or developmental studies have been done with this gel or with benzoyl peroxide. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Benoxiclin?
Using too much Benzoyl Peroxide 5% & Clindamycin 1% gel can cause severe irritation. If that happens, stop using the gel and wait until the skin has recovered. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Benoxiclin?
Keep Clindamycin + Benzoyl peroxide in a refrigerator at 2°-8°C, and don't let it freeze. Once it has been dispensed, don't store it above 25°C.
Can I take other medicines with Benoxiclin?
Some medicines can interact with Clindamycin + Benzoyl peroxide, for example: Chloramphenicol, Linezolid, Atracurium Besylate, Warfarin Sodium. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Benoxiclin?
Benoxiclin is a prescription (Rx) medicine. Take it as your doctor advises.