Indications & Uses
ATO Injection is indicated for:
Pharmacology
Scientists don't fully understand how Arsenic Trioxide works. In laboratory studies on NB4 human promyelocytic leukemia cells, it caused morphological changes and DNA fragmentation that are typical of apoptosis. Arsenic Trioxide also damages or breaks down the fusion protein promyelocytic leukemia (PML)-retinoic acid receptor (RAR)-alpha.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For newly diagnosed low-risk APL, Arsenic Trioxide is used together with tretinoin. During induction, give 0.15 mg/kg/day intravenously every day until the bone marrow goes into remission. Do not go beyond 60 days. For consolidation, give 0.15 mg/kg/day intravenously for 5 days per week during weeks 1 to 4 of each 8-week cycle, for a total of 4 cycles, again with tretinoin.
For relapsed or refractory APL, induction is 0.15 mg/kg/day intravenously every day until bone marrow remission, and this must not exceed 60 days. Consolidation is 0.15 mg/kg/day intravenously for 25 doses over a period of up to 5 weeks.
Side Effects
The most common adverse reactions (>30%) with Arsenic Trioxide are nausea, cough, fatigue, pyrexia, headache, abdominal pain, vomiting, tachycardia, diarrhea, dyspnea, hypokalemia, leukocytosis, hyperglycemia, hypomagnesemia, insomnia, dermatitis, edema, QTc prolongation, rigors, sore throat, arthralgia, paresthesia and pruritus.
Cautions & Contraindications
Warnings & Precautions
Hepatotoxicity Raised aspartate aminotransferase (AST), alkaline phosphatase and serum bilirubin have been seen in patients with newly-diagnosed low-risk APL who were given TRISENOX together with tretinoin. Check hepatic function tests at least twice weekly during induction and at least once weekly during consolidation. If AST, alkaline phosphatase or bilirubin rise to certain levels, hold TRISENOX, then restart at a reduced dose once the levels have settled. Carcinogenesis ATO is a human carcinogen. Patients should be watched for the development of second primary malignancies. Embryo-Fetal Toxicity Arsenic trioxide can cause fetal harm. Patients should be told about the possible risk to a fetus and advised to use effective contraception.
Contraindications
Arsenic Trioxide must not be given to patients who are hypersensitive to arsenic.
Use in Special Populations
Pediatric use: The safety and efficacy of ATO (arsenic trioxide) together with tretinoin have not been established in pediatric patients.
Geriatric use: Doctors saw no overall differences in safety or effectiveness between geriatric patients and younger patients.
Renal impairment: Patients with severe renal impairment may have higher exposure to ATO.
Hepatic impairment: Only limited data are available across all the hepatic impairment groups, so caution is advised when ATO is used in patients with hepatic impairment.
Storage
Keep Arsenic Trioxide at 20°C to 25°C, and don't let it freeze. ATO is a hazardous drug, so follow the special handling and disposal procedures that apply to it.
Drug Interactions
Common questions about ATO Injection 10 mg
What is ATO Injection 10 mg Injection?
ATO Injection 10 mg Injection is a medicine that contains Arsenic Trioxide. It is made by Beacon Pharmaceuticals PLC.
What is ATO Injection used for?
ATO Injection is used for: Cancer.
What are the side effects of ATO Injection?
The most common adverse reactions (>30%) with Arsenic Trioxide are nausea, cough, fatigue, pyrexia, headache, abdominal pain, vomiting, tachycardia, diarrhea, dyspnea, hypokalemia, leukocytosis, hyperglycemia, hypomagnesemia, insomnia, dermatitis, edema, QTc prolongation, rigors, sore throat, arthralgia, paresthesia and pruritus.
How should I store ATO Injection?
Keep Arsenic Trioxide at 20°C to 25°C, and don't let it freeze. ATO is a hazardous drug, so follow the special handling and disposal procedures that apply to it.
Can I take other medicines with ATO Injection?
Some medicines can interact with Arsenic Trioxide, for example: Tretinoin. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for ATO Injection?
ATO Injection is a prescription (Rx) medicine. Take it as your doctor advises.