Pricing

Watch price

10 mg

10 mg vial

৳1,500.00 per pack

Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.

All price changes →

A

ATO

Rx

10 mg • IV Infusion

Arsenic Trioxide • Beacon Pharmaceuticals PLC

🌐 বাংলায় দেখুন

From ৳1,500.00 10 mg vial

Available as: 10 mg · 10 mg vial

More from ATO

Other strengths and forms by Beacon Pharmaceuticals PLC

ATO Injection 10 mg Injection

Indications & Uses

ATO is indicated for:

Cancer

Pharmacology

Scientists don't fully understand how Arsenic Trioxide works. In laboratory studies on NB4 human promyelocytic leukemia cells, it caused morphological changes and DNA fragmentation that are typical of apoptosis. Arsenic Trioxide also damages or breaks down the fusion protein promyelocytic leukemia (PML)-retinoic acid receptor (RAR)-alpha.

Dosage Reference

Reference Information Only

Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.

Adults:

For newly diagnosed low-risk APL, Arsenic Trioxide is used together with tretinoin. During induction, give 0.15 mg/kg/day intravenously every day until the bone marrow goes into remission. Do not go beyond 60 days. For consolidation, give 0.15 mg/kg/day intravenously for 5 days per week during weeks 1 to 4 of each 8-week cycle, for a total of 4 cycles, again with tretinoin.

For relapsed or refractory APL, induction is 0.15 mg/kg/day intravenously every day until bone marrow remission, and this must not exceed 60 days. Consolidation is 0.15 mg/kg/day intravenously for 25 doses over a period of up to 5 weeks.

Side Effects

The most common adverse reactions (>30%) with Arsenic Trioxide are nausea, cough, fatigue, pyrexia, headache, abdominal pain, vomiting, tachycardia, diarrhea, dyspnea, hypokalemia, leukocytosis, hyperglycemia, hypomagnesemia, insomnia, dermatitis, edema, QTc prolongation, rigors, sore throat, arthralgia, paresthesia and pruritus.

Cautions & Contraindications

Warnings & Precautions

Hepatotoxicity Raised aspartate aminotransferase (AST), alkaline phosphatase and serum bilirubin have been seen in patients with newly-diagnosed low-risk APL who were given TRISENOX together with tretinoin. Check hepatic function tests at least twice weekly during induction and at least once weekly during consolidation. If AST, alkaline phosphatase or bilirubin rise to certain levels, hold TRISENOX, then restart at a reduced dose once the levels have settled. Carcinogenesis ATO is a human carcinogen. Patients should be watched for the development of second primary malignancies. Embryo-Fetal Toxicity Arsenic trioxide can cause fetal harm. Patients should be told about the possible risk to a fetus and advised to use effective contraception.

Contraindications

Arsenic Trioxide must not be given to patients who are hypersensitive to arsenic.

Use in Special Populations

Pediatric use: The safety and efficacy of ATO (arsenic trioxide) together with tretinoin have not been established in pediatric patients.

Geriatric use: Doctors saw no overall differences in safety or effectiveness between geriatric patients and younger patients.

Renal impairment: Patients with severe renal impairment may have higher exposure to ATO.

Hepatic impairment: Only limited data are available across all the hepatic impairment groups, so caution is advised when ATO is used in patients with hepatic impairment.

Storage

Keep Arsenic Trioxide at 20°C to 25°C, and don't let it freeze. ATO is a hazardous drug, so follow the special handling and disposal procedures that apply to it.

Drug Interactions

Open checker →

Moderate Tretinoin

Common questions about ATO 10 mg

What is ATO 10 mg IV Infusion?

ATO 10 mg IV Infusion is a medicine that contains Arsenic Trioxide. It is made by Beacon Pharmaceuticals PLC.

What is ATO used for?

ATO is used for: Cancer.

What are the side effects of ATO?