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Indications & Uses
Arthera is indicated for:
Pharmacology
Iguratimod has immunomodulatory effects, because it acts on both T and B lymphocytes to suppress the immune response. Its anti-inflammatory action comes from inhibiting the production of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6 and IL-17, which contribute to inflammation. It also has an osteoprotective activity. Iguratimod promotes bone formation while inhibiting the differentiation and activity of osteoclasts, the cells that resorb bone.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For rheumatoid arthritis, the usual adult dose of Iguratimod is 25 mg by mouth twice daily, taken in the morning and evening after meals. Some doctors start with 25 mg once daily for 1 to 2 weeks so the patient can tolerate it better, and then increase to 25 mg twice daily.
In mild kidney or liver impairment, the dose usually doesn't need to change, but the medicine should still be used with caution. It is not typically recommended for children, because its safety and efficacy haven't been established in them. Liver function, kidney function and blood counts need to be checked regularly during treatment. Iguratimod is often used alone, or together with methotrexate or other DMARDs.
Side Effects
Common side effects of Iguratimod fall into three groups. Gastrointestinal side effects include nausea, stomach pain, diarrhea and indigestion. General side effects include headache, dizziness and tiredness. Laboratory findings can show a mild increase in liver enzymes (ALT, AST), and sometimes a mild decrease in blood counts.
Cautions & Contraindications
Warnings & Precautions
Liver toxicity Iguratimod may raise liver enzymes (ALT, AST). Liver function tests (LFTs) are needed at the start and then from time to time. Stop the medicine if significant hepatotoxicity occurs. Bone marrow suppression It can cause leukopenia, neutropenia, anemia or thrombocytopenia, so CBC should be checked regularly. Renal impairment Use with caution and monitor renal function. Infections Being an immunomodulator, Iguratimod can increase the risk of infections (respiratory, urinary, etc.). Don't use it in patients with active infections (e.g., TB, hepatitis). Gastrointestinal effects Nausea, dyspepsia and diarrhea may occur. Taking the medicine after meals helps reduce GI upset. Pregnancy & breastfeeding Iguratimod is contraindicated because it may cause fetal harm. Effective contraception is required during treatment and for some time after discontinuation. Drug interactions Be careful when it is used with other immunosuppressants, DMARDs, hepatotoxic drugs or anticoagulants. Combining it with methotrexate is common, but it needs close monitoring.
Storage
Store Iguratimod below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Common questions about Arthera 25 mg
What is Arthera 25 mg Tablet?
Arthera 25 mg Tablet is a medicine that contains Iguratimod. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Disease-modifying antirheumatic drugs (DMARDs) group of medicines.
What is Arthera used for?
Arthera is used for: Rheumatoid Arthritis.
What are the side effects of Arthera?
Common side effects of Iguratimod fall into three groups. Gastrointestinal side effects include nausea, stomach pain, diarrhea and indigestion.
How should I store Arthera?
Store Iguratimod below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Is there a cheaper medicine with the same ingredient?
Arthera is already among the lowest-priced brands of Iguratimod at this strength.
Do I need a prescription for Arthera?
Arthera is a prescription (Rx) medicine. Take it as your doctor advises.