Pricing
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All price changes →Indications & Uses
Alurol is used to reduce the making of urate, also called uric acid, in people who already have urate or uric acid built up in the body. This includes gouty arthritis, skin tophi and kidney stones (nephrolithiasis). Alurol is also used to treat 2,8-dihydroxyadenine (2,8-DHA) kidney stones caused by low activity of the enzyme adenine phospho ribosyltransferase. Another use is for recurrent mixed calcium oxalate kidney stones when there is too much uric acid in the urine (hyperuricosuria), but only after fluids, diet and similar measures have not worked.
Pharmacology
Allopurinol is a xanthine oxidase inhibitor, and you take it by mouth. It works on purine catabolism (the breakdown of purines) and leaves the making of purines alone. It lowers uric acid production by blocking the biochemical steps that come just before uric acid is formed.
Structurally, allopurinol is an analogue of hypoxanthine, a natural purine base. Xanthine oxidase is the enzyme that converts hypoxanthine to xanthine, and then xanthine to uric acid, which is the end product of purine metabolism. Allopurinol inhibits this enzyme.
About 90% of a dose is absorbed from the GI tract. Peak plasma levels usually come between 1.5 hours and 4.5 hours after the dose. The plasma half life is about 1 to 2 hours. Around 20% of the allopurinol swallowed is excreted in the faeces.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults: Doctors usually start allopurinol at a low dose, such as 100 mg per day, to limit the chance of side effects, and increase it only if the response in serum urate levels is not satisfactory. Extra care is needed when kidney function is poor. Suggested dosage schedules are 100 to 200 mg daily for mild conditions, 300 to 600 mg daily for moderately severe conditions, and 700 to 900 mg daily for severe conditions.
Children: In children under 15 years, the dose is 10 to 20 mg per kg of body weight per day, up to a maximum of 400 mg daily. Use in children is rarely needed, except in malignant conditions (especially leukaemia) and certain enzyme disorders such as Lesch-Nyhan syndrome.
Elderly: Without specific data to guide dosing, the lowest dose that gives a satisfactory reduction in urate should be used.
Dosage in renal impairment: In severe renal insufficiency, it may be best to use less than 100 mg per day, or to give single doses of 100 mg at intervals longer than one day.
Side Effects
Rashes, gastrointestinal upset, and occasionally malaise, headache, dizziness, drowsiness, and disturbances of vision and taste may occur. Other reported effects include high blood pressure, hair loss, liver toxicity, nerve damage, breast enlargement in men, and blood disorders.
Cautions & Contraindications
Warnings & Precautions
Alurol should be stopped right away if a skin rash or any other sign of sensitivity develops. In patients with liver or kidney impairment, a reduced dose should be used. People being treated for high blood pressure or heart failure may also have some degree of reduced kidney function, so Alurol should be used cautiously in this group.
Contraindications
Allopurinol tablets should not be used by anyone who is known to be hypersensitive (allergic) to allopurinol.
Pregnancy & Breastfeeding
There isn't enough evidence to confirm Allopurinol is safe to use during human pregnancy. It should only be used in pregnancy if no safer option is available and if the underlying condition itself poses a risk to the mother or the unborn child. No information is currently available on how allopurinol or its breakdown products affect a breastfeeding baby.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
One patient is reported to have taken up to 22.5 g of Purinol with no adverse effect. Another patient who took 20 gm had nausea, vomiting, diarrhoea and dizziness. Drinking enough fluid to keep urine output at a good level helps the body clear Purinol and its metabolites. Haemodialysis can be used if it is thought necessary.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Allopurinol below 30°C, away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Alurol 100 mg
What is Alurol 100 mg Tablet?
Alurol 100 mg Tablet is a medicine that contains Allopurinol. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Drugs used in Gout group of medicines.
What is Alurol used for?
Alurol is used to reduce the making of urate, also called uric acid, in people who already have urate or uric acid built up in the body. This includes gouty arthritis, skin tophi and kidney stones (nephrolithiasis).
What are the side effects of Alurol?
Rashes, gastrointestinal upset, and occasionally malaise, headache, dizziness, drowsiness, and disturbances of vision and taste may occur. Other reported effects include high blood pressure, hair loss, liver toxicity, nerve damage, breast enlargement in men, and blood disorders.
Can I take Alurol during pregnancy or while breastfeeding?
There isn't enough evidence to confirm Allopurinol is safe to use during human pregnancy. It should only be used in pregnancy if no safer option is available and if the underlying condition itself poses a risk to the mother or the unborn child. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Alurol?
One patient is reported to have taken up to 22.5 g of Purinol with no adverse effect. Another patient who took 20 gm had nausea, vomiting, diarrhoea and dizziness. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Alurol?
Store Allopurinol below 30°C, away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Alurol?
Some medicines can interact with Allopurinol, for example: Amoxicillin + Clavulanic Acid, Chlorthalidone, Doxophylline, Theophylline, Aluminium Oxide + Magnesium Trisilicate, Phenytoin Sodium. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Alurol is already among the lowest-priced brands of Allopurinol at this strength.
Do I need a prescription for Alurol?
Alurol is a prescription (Rx) medicine. Take it as your doctor advises.