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Indications & Uses
Acilog Mix is indicated for:
Pharmacology
Biphasic Insulin Aspart (30% Insulin Aspart and 70% Insulin Aspart Protamine, rDNA) is a human insulin analog suspension. It contains 30% soluble Insulin Aspart and 70% Insulin Aspart Protamine crystals. This medicine lowers blood glucose, and it has an earlier onset and an intermediate duration of action.
Insulin Aspart is homologous with regular human insulin, with one exception: the proline in position B28 is replaced by aspartic acid. It is made by recombinant DNA technology using Saccharomyces cerevisiae (baker's yeast).
The primary function of insulin, including Insulin Aspart, is to regulate glucose metabolism. Insulin and its analogs lower blood glucose by stimulating peripheral glucose uptake, mainly by skeletal muscle and fat, and by inhibiting hepatic glucose production. Insulin also inhibits lipolysis and proteolysis, and it enhances protein synthesis.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Biphasic Insulin Aspart doses must be worked out for each person individually.
For subcutaneous injection, insulin aspart should generally be given immediately, within 5 to 10 minutes before a meal starts.
When it is used in a pump, change the insulin aspart in the reservoir at least every 6 days. The infusion set and the infusion set insertion site should be changed at least every 3 days. Don't mix insulin aspart with other insulins or with a diluent in the pump.
For intravenous use, insulin aspart should be used at concentrations from 0.05 U/mL to 1.0 U/mL in infusion systems that use polypropylene infusion bags. It has been shown to be stable in infusion fluids such as 0.9% sodium chloride.
Side Effects
Insulin Aspart can cause hypoglycemia, lipodystrophy, weight gain and peripheral edema.
Cautions & Contraindications
Warnings & Precautions
Dose adjustment and monitoring Anyone treated with Biphasic Insulin Aspart, or any other insulin, should have their blood glucose monitored. Change the insulin regimen carefully, and only under medical supervision. Renal or hepatic impairment In people with kidney or liver problems, the dose of Insulin Aspart may need to be reduced.
Contraindications
Biphasic Insulin Aspart (rDNA) must not be used during episodes of hypoglycemia. It must also not be used in people who are hypersensitive to Insulin Aspart or to any of its excipients.
Pregnancy & Breastfeeding
Biphasic Insulin Aspart is pregnancy category B. Blood glucose needs careful monitoring in pregnant women, because insulin requirements change at different stages of pregnancy. So women taking insulin aspart should be told to inform their doctor if they plan to become pregnant, or if they become pregnant while on it.
Lactation: It is not known whether insulin aspart passes into human milk, as human insulin does. There are no adequate and well-controlled studies of insulin aspart in breastfeeding women. Women who are breastfeeding may need their insulin doses adjusted.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Children: Biphasic Insulin Aspart has not been studied in children with type 2 diabetes. It has also not been studied in children with type 1 diabetes who are under 2 years of age.
Overdose
Too much Insulin Aspart can cause hypoglycemia. If the episode is mild, oral carbohydrates will usually bring the sugar back up. Severe hypoglycemia may need glucose given parenterally or an injection of glucagon. After an overdose, the dose of the medicine, the pattern of meals or the amount of exercise may also need to be adjusted.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Biphasic Insulin Aspart in a refrigerator at 2°C to 8°C, and don't let it freeze. The insulin you are using at the moment doesn't need to go in the refrigerator. Keep it in a cool place, away from heat and light. You can leave the insulin in use at room temperature for a month.
Drug Interactions
Common questions about Acilog Mix 30%+70%
What is Acilog Mix 30%+70% SC Injection?
Acilog Mix 30%+70% SC Injection is a medicine that contains Biphasic Insulin Aspart. It is made by Advanced Chemical Industries PLC. It belongs to the Combination Insulin group of medicines.
What is Acilog Mix used for?
Acilog Mix is used for: Type 2 Diabetes Mellitus, Type 1 Diabetes Mellitus, Diabetes Mellitus.
What are the side effects of Acilog Mix?
Insulin Aspart can cause hypoglycemia, lipodystrophy, weight gain and peripheral edema.
Can I take Acilog Mix during pregnancy or while breastfeeding?
Biphasic Insulin Aspart is pregnancy category B. Blood glucose needs careful monitoring in pregnant women, because insulin requirements change at different stages of pregnancy. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Acilog Mix?
Too much Insulin Aspart can cause hypoglycemia. If the episode is mild, oral carbohydrates will usually bring the sugar back up. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Acilog Mix?
Keep Biphasic Insulin Aspart in a refrigerator at 2°C to 8°C, and don't let it freeze. The insulin you are using at the moment doesn't need to go in the refrigerator.
Can I take other medicines with Acilog Mix?
Some medicines can interact with Biphasic Insulin Aspart, for example: Niacin, Isoniazid, Disopyramide, Somatropin, Danazol, Fluoxetine. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Acilog Mix?
Acilog Mix is a prescription (Rx) medicine. Take it as your doctor advises.