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These brands contain the same active ingredient (Vilanterol Trifenatate + Fluticasone Furoate + Umeclidinium Bromide). Same strength and form. Confirm the switch with your doctor or pharmacist.
Tritide
Rx25 mcg+100 mcg+62.5 mcg • Dry Powder Inhalation Capsule (DPI)
Indications & Uses
Tritide is indicated for:
Pharmacology
This capsule contains an inhalation powder that delivers three medicines by oral inhalation: fluticasone furoate (an ICS), umeclidinium (an anticholinergic) and vilanterol (a LABA). The effects of beta 2-adrenoceptor agonists such as vilanterol come, at least in part, from stimulating intracellular adenyl cyclase. This enzyme catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3, 5 -adenosine monophosphate (cyclic AMP). Higher cyclic AMP levels relax the bronchial smooth muscle and inhibit the release of mediators of immediate hypersensitivity from cells, especially from mast cells. The precise way fluticasone furoate affects COPD and asthma symptoms is not known. Inflammation is an important part of how COPD and asthma develop, and corticosteroids have been shown to act on many cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, lymphocytes) and many mediators (e.g., histamine, eicosanoids, leukotrienes, cytokines) involved in inflammation. Umeclidinium is a long-acting muscarinic antagonist, often called an anticholinergic. It has similar affinity for the muscarinic receptor subtypes M1 to M5. In the airways, it works by inhibiting the M3 receptor at the smooth muscle, which leads to bronchodilation.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Don't swallow the Vilanterol Trifenatate + Fluticasone Furoate + Umeclidinium Bromide inhalation capsule. Use it only with the device, and take the capsule out of the blister pack just before you put it into the inhalation device. After inhaling, rinse your mouth with water without swallowing it, to reduce the risk of oropharyngeal candidiasis.
Adults (18 years or older) should use the capsule at the same time every day, and not more than once every 24 hours. If shortness of breath or other asthma symptoms come on between doses, take an inhaled SABA (Short Acting β-Agonist) for immediate relief.
Maintenance treatment of COPD: 1 inhalation capsule once daily.
Maintenance treatment of Asthma: 1 inhalation capsule once daily.
Side Effects
With Vilanterol Trifenatate + Fluticasone Furoate + Umeclidinium Bromide in COPD, the most common adverse reactions (those seen in 1% or more of patients) are upper respiratory tract infection, pneumonia, bronchitis, oral candidiasis, headache, back pain, arthralgia, influenza, sinusitis, pharyngitis, rhinitis, dysgeusia, constipation, urinary tract infection, diarrhoea, gastroenteritis, oropharyngeal pain, cough and dysphonia. In asthma, the most common adverse reactions (those seen in 2% or more) are pharyngitis/nasopharyngitis, upper respiratory tract infection/viral upper respiratory tract infection, bronchitis, respiratory tract infection/viral respiratory tract infection, sinusitis/acute sinusitis, urinary tract infection, rhinitis, influenza, headache and back pain.
Cautions & Contraindications
Warnings & Precautions
A LABA used alone raises the risk of serious asthma-related events. Don't start Vilanterol Trifenatate + Fluticasone Furoate + Umeclidinium Bromide in COPD or asthma that is getting worse suddenly, and don't use it to treat sudden symptoms. Don't use it together with any other therapy that contains a LABA, because of the risk of overdose. A Candida albicans infection of the mouth and throat may occur, so check patients from time to time. Advise the patient to rinse the mouth with water after inhalation and not to swallow the water, as this helps reduce the risk. The risk of pneumonia is higher in patients with COPD, so watch them for signs and symptoms of pneumonia. If paradoxical bronchospasm occurs, stop the medicine and start alternative therapy. Use it with caution in patients with cardiovascular disorders, because of beta-adrenergic stimulation. Urinary retention may get worse, so be careful in patients with prostatic hyperplasia or bladder-neck obstruction. Take the same care in patients with convulsive disorders, thyrotoxicosis, diabetes mellitus and ketoacidosis.
Contraindications
Don't use this medicine as the main treatment for status asthmaticus, or for acute episodes of COPD or asthma that need intensive measures. Don't use it either if you have a severe hypersensitivity to milk proteins or to any of its ingredients.
Use in Special Populations
Children and adolescents: This combination of vilanterol trifenatate, fluticasone furoate and umeclidinium bromide is not indicated for use in children and adolescents. Safety and efficacy have not been established in pediatric patients aged 17 years and younger.
Elderly population: Based on the data available, the dose doesn't need to be adjusted in older patients. Still, some older people may be more sensitive to the medicine, and that cannot be ruled out.
Renal impairment: The medicine has not been studied in people with renal impairment.
Hepatic impairment: The medicine has not been studied in people with hepatic impairment.
Overdose
Clinical trials have not produced any data on overdose with this inhalation capsule.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep this medicine away from direct sunlight and heat. Store it in a cool, dry place. Keep it away from your eyes and out of reach of children.
Drug Interactions
Common questions about Tritide 25 mcg+100 mcg+62.5 mcg
What is Tritide 25 mcg+100 mcg+62.5 mcg Dry Powder Inhalation Capsule (DPI)?
Tritide 25 mcg+100 mcg+62.5 mcg Dry Powder Inhalation Capsule (DPI) is a medicine that contains Vilanterol Trifenatate + Fluticasone Furoate + Umeclidinium Bromide. It is made by Unimed Unihealth Pharmaceuticals Ltd. It belongs to the Combined bronchodilators group of medicines.
What is Tritide used for?
Tritide is used for: Asthma, Chronic Obstructive Pulmonary Disease.
What are the side effects of Tritide?
With Vilanterol Trifenatate + Fluticasone Furoate + Umeclidinium Bromide in COPD, the most common adverse reactions (those seen in 1% or more of patients) are upper respiratory tract infection, pneumonia, bronchitis, oral candidiasis, headache, back pain, arthralgia, influenza, sinusitis, pharyngitis, rhinitis, dysgeusia, constipation, urinary tract infection, diarrhoea, gastroenteritis, oropharyngeal pain, cough and dysphonia. In asthma, the most common adverse reactions (those seen in 2% or more) are pharyngitis/nasopharyngitis, upper respiratory tract infection/viral upper respiratory tract infection, bronchitis, respiratory tract infection/viral respiratory tract infection, sinusitis/acute sinusitis, urinary tract infection, rhinitis, influenza, headache and back pain.
What happens if I take too much Tritide?
Clinical trials have not produced any data on overdose with this inhalation capsule. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Tritide?
Keep this medicine away from direct sunlight and heat. Store it in a cool, dry place.
Can I take other medicines with Tritide?
Some medicines can interact with Vilanterol Trifenatate + Fluticasone Furoate + Umeclidinium Bromide, for example: Ketoconazole. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Respimax Pro by Incepta Pharmaceuticals Ltd. has the same ingredient and strength for ৳45.00 per unit, compared with ৳90.00 for Tritide. Ask your doctor or pharmacist before switching.
Do I need a prescription for Tritide?
Tritide is a prescription (Rx) medicine. Take it as your doctor advises.