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These brands contain the same active ingredient (Vilanterol Trifenatate + Fluticasone Furoate + Umeclidinium Bromide). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Trilexa
Rx25 mcg+200 mcg+62.5 mcg • Dry Powder Inhalation Capsule (DPI)
Indications & Uses
Trilexa is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
This inhalation capsule must not be swallowed. Only to be used with the device. Remove the capsule from the blister pack only immediately before using it in the inhalation device. After inhalation, rinse your mouth with water without swallowing to reduce the risk of oropharyngeal candidiasis.Adults (18 years or older): Should be used at the same time every day, not more than once every 24 hours. If shortness of breath or other asthma symptoms arise in the period between doses, an inhaled SABA (Short Acting β-Agonist) should be taken for immediate relief.Maintenance treatment of COPD: 1 inhalation capsule once daily.Maintenance treatment of Asthma: 1 inhalation capsule once daily.
Side Effects
COPD: Most common adverse reactions (incidence ≥1%) are upper respiratory tract infection, pneumonia, bronchitis, oral candidiasis, headache, back pain, arthralgia, infuenza, sinusitis, pharyngitis, rhinitis, dysgeusia, constipation, urinary tract infection, diarrhea, gastroenteritis, oropharyngeal pain, cough, and dysphonia.Asthma: Most common adverse reactions (incidence ≥2%) are pharyngitis/nasopharyngitis, upper respiratory tract infection/viral upper respiratory tract infection, bronchitis, respiratory tract infection/viral respiratory tract infection, sinusitis/acute sinusitis, urinary tract infection, rhinitis, infuenza, headache, and back pain.
Cautions & Contraindications
Warnings & Precautions
LABA monotherapy increases the risk of serious asthma-related events. Do not initiate in acutely deteriorating COPD or asthma. Do not use to treat acute symptoms. Do not use in combination with additional therapy containing a LABA because of risk of overdose. Candida albicans infection of the mouth and pharynx may occur. Monitor patients periodically. Advise the patient to rinse his/her mouth with water without swallowing after inhalation to help reduce the risk. Increased risk of pneumonia in patients with COPD. Monitor patients for signs and symptoms of pneumonia. If paradoxical bronchospasm occurs, discontinue and institute alternative therapy. Use with caution in patients with cardiovascular disorders because of beta-adrenergic stimulation. Worsening of urinary retention may occur. Use with caution in patients with prostatic hyperplasia or bladder-neck obstruction. Use with caution in patients with convulsive disorders, thyrotoxicosis, diabetes mellitus, and ketoacidosis.
Contraindications
Primary treatment of status asthmaticus or acute episodes of COPD or asthma requiring intensive measures Severe hypersensitivity to milk proteins or any ingredients.