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Other brands with the same active ingredient
These brands contain the same active ingredient (Sotalol Hydrochloride). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Sotalol HCl 80 mg is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Initially 80 mg daily in 1 to 2 divided doses. After ECG monitoring and measurement of corrected QT interval and arrhythmias, the dose is increased gradually at intervals of 2 to 3 days to a usual dose of 160 to 320 mg daily in 2 divided doses; higher doses of 480 to 640 mg daily may be used for life-threatening ventricular arrhythmias under specialist supervision. The dosage should be reduced in renal impairment. If creatinine clearance is greater than 60 ml/min, the recommended dose is 160 mg twice daily, while in those with creatinine clearance between 40 and 60 ml/min, the dose is given once daily. In patients with creatinine clearance less than 40 ml/min, Sotalol is contraindicated.
Side Effects
The most notable side effects of Sotalol are those typically seen with class I and class II antiarrhythmic actions, including a prolonged duration of the cardiac action potential.
Cautions & Contraindications
Warnings & Precautions
Sotalex isn't suitable for every patient with irregular heart rhythms (atrial fibrillation). It should not be used by people who have serious kidney problems or are on dialysis; lung disease causing breathlessness (such as asthma, chronic bronchitis, or emphysema); signs of heart failure (such as breathlessness on exertion or swelling of the ankles or legs); or a very slow heartbeat without an implanted pacemaker.
Contraindications
Sotalol should not be used in patients with a slow heart rate (sinus bradycardia), sick sinus syndrome, or second- or third-degree AV block, unless a functional pacemaker is fitted. It is also contraindicated in those with congenital or acquired long QT syndrome, torsades de pointes, uncontrolled congestive heart failure, or cardiogenic shock. Further contraindications include anaesthesia likely to depress heart function, hypotension not caused by an arrhythmia, severe peripheral circulatory disturbances, chronic obstructive airway disease or bronchial asthma, renal failure (creatinine clearance below 40 mL/min), and known hypersensitivity to sotalol. Sotalol should not be given to patients with diabetic ketoacidosis or metabolic acidosis; treatment can be started or resumed once the underlying metabolic condition has been corrected.