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Same active ingredient — pay up to 82% less
These brands contain the same active ingredient (Pregabalin). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Nervalin CR is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage Neuropathic pain associated with diabetic peripheral neuropathy in adults (DPN): The maximum recommended dose of Pregabalin is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 ml/min. Dosing should begin at 50 mg three times a day (150 mg/day). The dose may be increased to 300 mg/day within 1 week based on efficacy and tolerability. Begin dosing of Pregabalin CR capsule at 165 mg once daily and increase to 330 mg once daily within 1 week based on individual patient response and tolerability. The maximum recommended dose of Pregabalin CR capsule is 330 mg once daily.Postherpetic neuralgia in adults (PHN): The recommended dose of Pregabalin is 75 to 150 mg two times a day or 50 to 100 mg three times a day (150 to 300 mg/day) in patients with creatinine clearance of at least 60 ml/min. Dosing should begin at 75 mg two times a day or 50 mg three times a day (150 mg/day). The dose may be increased to 300 mg/day within 1 week based on efficacy and tolerability. Patients who do not experience sufficient pain relief following 2 to 4 weeks of treatment with 300 mg/day and who are able to tolerate Pregabalin, may be treated with up to 300 mg two times a day or 200 mg three times a day (600 mg/day).Begin dosing of Pregabalin CR capsule at 165 mg once daily and increase to 330 mg once daily within 1 week based on individual patient response and tolerability. Patients who do not experience sufficient pain relief following 2 to 4 weeks of treatment with 330 mg once daily and who are able to tolerate Pregabalin CR capsule, may be treated with up to 660 mg once daily. In view of the dose-dependent adverse reactions and the higher rate of treatment discontinuation due to adverse reactions, dosing above 330 mg/day should be reserved only for those patients who have on-going pain and are tolerating 330 mg daily. The maximum recommended dose of Pregabalin CR capsule is 660 mg once daily.Management of fibromyalgia in adults: The recommended dose of Pregabalin is 300 to 450 mg/day. Dosing should begin at 75 mg two times a day (150 mg/day). The dose may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability. Patients who do not experience sufficient benefit with 300 mg/day may be further increased to 225 mg two times a day (450 mg/day).Neuropathic pain associated with spinal cord injury in adults: The recommended dose range of Pregabalin is 150 to 600 mg/day. The recommended starting dose is 75 mg two times a day (150 mg/day). The dose may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability. Patients who do not experience sufficient pain relief after 2 to 3 weeks of treatment with 150 mg two times a day and who tolerate Pregabalin may be treated with up to 300 mg two times a day. Conversion from Pregabalin capsules to Pregabalin CR capsule tablet: When switching from Pregabalin capsules to Pregabalin CR capsule tablet on the day of the switch, instruct patients to take their morning dose of Pregabalin capsule as prescribed and initiate Pregabalin CR capsule therapy after an evening meal.Pregabalin tablet total daily dose (dosed 2 or 3 times daily): Pregabalin CR capsule capsule dose (dosed once a day) 75 mg/daily: 82.5 mg/day 150 mg/daily: 165 mg/day 225 mg/daily: 247.5 mg/day 300 mg/daily: 330 mg/day 450 mg/daily: 495 mg/day 600 mg/daily: 660 mg/day
Side Effects
Most adults taking pregabalin tend to notice dizziness and drowsiness, along with dry mouth, swelling (edema), blurred vision, weight gain, and some difficulty concentrating or thinking clearly. In children being treated for partial-onset seizures, the main issues reported are weight gain and an increased appetite.
Cautions & Contraindications
Warnings & Precautions
Angioedema (for example, swelling of the throat, head, and neck) can occur and may be associated with life threatening respiratory compromise requiring emergency treatment. Rebalin should be discontinued immediately in these cases. Rebalin should also be discontinued immediately if hypersensitivity reactions (for example, hives, dyspnea and wheezing) occur. Antiepileptic drugs, including Rebalin, increase the risk of suicidal thoughts or behavior. Respiratory depression may occur with Rebalin when it is used together with other central nervous system (CNS) depressants or in patients with underlying respiratory impairment. Patients need to be monitored and their dosage adjusted as appropriate. Rebalin may cause dizziness and somnolence and can impair a patient's ability to drive or operate machinery. Increased seizure frequency or other adverse reactions may occur if Rebalin is stopped too quickly. Rebalin should instead be withdrawn gradually over a minimum of 1 week. Rebalin may cause peripheral edema. Caution should be exercised when Rebalin is given together with thiazolidinedione antidiabetic agents.
Contraindications
Pregabalin should not be used by patients who are known to be hypersensitive to Pregabalin or to any of the other ingredients in the formulation.