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Other brands with the same active ingredient
These brands contain the same active ingredient (Pregabalin). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
AGP is indicated for:
Pharmacology
Pregabalin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), but it does not act directly on GABAA, GABAB, or benzodiazepine receptors. Instead, it binds with high affinity to the alpha2-delta site, an auxiliary subunit of voltage-gated calcium channels in central nervous system tissue. Pregabalin's exact mechanism of action is not yet fully understood, but animal studies suggest that this binding to the alpha2-delta subunit may contribute to its pain-relieving and antiseizure effects.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Diabetic peripheral neuropathy (DPN) in adults: The maximum recommended dose of Pregabalin is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 ml/min. Treatment should begin at 50 mg three times a day (150 mg/day). Based on how well it works and how well the patient tolerates it, the dose may be raised to 300 mg/day within 1 week. For the Pregabalin CR capsule, start at 165 mg once daily and increase to 330 mg once daily within 1 week, depending on the individual patient's response and tolerability. The maximum recommended dose of the Pregabalin CR capsule is 330 mg once daily.
Postherpetic neuralgia (PHN) in adults: The recommended dose of Pregabalin is 75 to 150 mg two times a day or 50 to 100 mg three times a day (150 to 300 mg/day) in patients with creatinine clearance of at least 60 ml/min. Treatment should begin at 75 mg two times a day or 50 mg three times a day (150 mg/day). The dose may be raised to 300 mg/day within 1 week, based on efficacy and tolerability. If a patient gets insufficient pain relief after 2 to 4 weeks on 300 mg/day, and is able to tolerate Pregabalin, the dose may go up to 300 mg two times a day or 200 mg three times a day (600 mg/day).
For the Pregabalin CR capsule, start at 165 mg once daily and increase to 330 mg once daily within 1 week, based on individual response and tolerability. If pain relief is insufficient after 2 to 4 weeks on 330 mg once daily, and the patient tolerates the Pregabalin CR capsule, up to 660 mg once daily may be used. The adverse reactions are dose-dependent, and more patients stop treatment because of them at higher doses. So dosing above 330 mg/day should be kept only for patients who still have ongoing pain and are tolerating 330 mg daily. The maximum recommended dose of the Pregabalin CR capsule is 660 mg once daily.
Management of fibromyalgia in adults: The recommended dose of Pregabalin is 300 to 450 mg/day. Treatment should begin at 75 mg two times a day (150 mg/day). Within 1 week, the dose may be increased to 150 mg two times a day (300 mg/day), based on efficacy and tolerability. If a patient doesn't get enough benefit from 300 mg/day, it may be increased further to 225 mg two times a day (450 mg/day).
Neuropathic pain associated with spinal cord injury in adults: The recommended dose range of Pregabalin is 150 to 600 mg/day. The recommended starting dose is 75 mg two times a day (150 mg/day). The dose may be increased to 150 mg two times a day (300 mg/day) within 1 week, based on efficacy and tolerability. Patients who don't get enough pain relief after 2 to 3 weeks on 150 mg two times a day, and who tolerate Pregabalin, may be treated with up to 300 mg two times a day.
Conversion from Pregabalin capsules to Pregabalin CR capsule: When switching, patients should take their morning dose of the Pregabalin capsule as prescribed on the day of the switch. They should then start the Pregabalin CR capsule after an evening meal.
Pregabalin total daily dose (taken 2 or 3 times daily) and the matching Pregabalin CR capsule dose (taken once a day):
75 mg/day: 82.5 mg/day
150 mg/day: 165 mg/day
225 mg/day: 247.5 mg/day
300 mg/day: 330 mg/day
450 mg/day: 495 mg/day
600 mg/day: 660 mg/day
Side Effects
Most adults taking pregabalin tend to notice dizziness and drowsiness, along with dry mouth, swelling (edema), blurred vision, weight gain, and some difficulty concentrating or thinking clearly. In children being treated for partial-onset seizures, the main issues reported are weight gain and an increased appetite.
Cautions & Contraindications
Warnings & Precautions
Angioedema (for example, swelling of the throat, head, and neck) can occur and may be associated with life threatening respiratory compromise requiring emergency treatment. Rebalin should be discontinued immediately in these cases. Rebalin should also be discontinued immediately if hypersensitivity reactions (for example, hives, dyspnea and wheezing) occur. Antiepileptic drugs, including Rebalin, increase the risk of suicidal thoughts or behavior. Respiratory depression may occur with Rebalin when it is used together with other central nervous system (CNS) depressants or in patients with underlying respiratory impairment. Patients need to be monitored and their dosage adjusted as appropriate. Rebalin may cause dizziness and somnolence and can impair a patient's ability to drive or operate machinery. Increased seizure frequency or other adverse reactions may occur if Rebalin is stopped too quickly. Rebalin should instead be withdrawn gradually over a minimum of 1 week. Rebalin may cause peripheral edema. Caution should be exercised when Rebalin is given together with thiazolidinedione antidiabetic agents.
Contraindications
Pregabalin should not be used by patients who are known to be hypersensitive to Pregabalin or to any of the other ingredients in the formulation.
Pregnancy & Breastfeeding
Pregnancy & Breastfeeding
There haven't been enough well-controlled studies of pregabalin in pregnant women to establish its safety, so pregnant women should be made aware of the possible risk to the baby. Trace amounts of pregabalin have also been found in the breast milk of nursing mothers, and because of a possible risk of tumour formation, breastfeeding is not advised while being treated with pregabalin.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Use in children and adolescents: Pregabalin has not been shown to be safe or effective in paediatric patients for neuropathic pain linked to diabetic peripheral neuropathy, postherpetic neuralgia or spinal cord injury, or for fibromyalgia. When it is used as add-on therapy for partial onset seizures, safety and effectiveness have not been established in children below the age of 1 month. The safety and effectiveness of Pregabalin extended-release tablet in paediatric patients have not been established either.
Overdose
An overdose of Pregabalin can cause reduced consciousness, depression or anxiety, a confusional state, agitation and restlessness. Seizures and heart block have also been reported.
There is no specific antidote. If it's indicated, the doctor may try to remove any unabsorbed drug by inducing vomiting or by gastric lavage, taking the usual precautions to keep the airway protected. The patient also needs general supportive care, which includes monitoring vital signs and watching the patient's clinical status.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Pregabalin in a cool, dry place below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about AGP 75 mg
What is AGP 75 mg Capsule?
AGP 75 mg Capsule is a medicine that contains Pregabalin. It is made by Novo Healthcare and Pharma Ltd. It belongs to the Adjunct anti-epileptic drugs group of medicines.
What is AGP used for?
AGP is used for: Epilepsy, Neuropathic Pain, Pain.
What are the side effects of AGP?
Most adults taking pregabalin tend to notice dizziness and drowsiness, along with dry mouth, swelling (edema), blurred vision, weight gain, and some difficulty concentrating or thinking clearly. In children being treated for partial-onset seizures, the main issues reported are weight gain and an increased appetite.
Can I take AGP during pregnancy or while breastfeeding?
Pregnancy & Breastfeeding There haven't been enough well-controlled studies of pregabalin in pregnant women to establish its safety, so pregnant women should be made aware of the possible risk to the baby. Trace amounts of pregabalin have also been found in the breast milk of nursing mothers, and because of a possible risk of tumour formation, breastfeeding is not advised while being treated with pregabalin. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much AGP?
An overdose of Pregabalin can cause reduced consciousness, depression or anxiety, a confusional state, agitation and restlessness. Seizures and heart block have also been reported. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store AGP?
Store Pregabalin in a cool, dry place below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with AGP?
Some medicines can interact with Pregabalin, for example: Amisulpride. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for AGP?
AGP is a prescription (Rx) medicine. Take it as your doctor advises.