ইঙ্গিত ও ব্যবহার
Lurbin এর জন্য নির্দেশিত:
ডোজ নির্দেশিকা
শুধুমাত্র নির্দেশিকা তথ্য
প্রদর্শিত ডোজগুলি সরকারি উৎসের সাধারণ নির্দেশিকা। ব্যক্তিগতকৃত ডোজের জন্য সর্বদা আপনার ডাক্তার বা ফার্মাসিস্টের পরামর্শ নিন।
প্রাপ্তবয়স্ক:
The recommended dosage of Lurbinectedin is 3.2 mg/m2 by intravenous infusion over 60 minutes every 21 days until disease progression or unacceptable toxicity.Initiate treatment with Lurbinectedin only if absolute neutrophil count (ANC) is at least 1,500 cells/mm3 and platelet count is at least 100,000/mm3.
পার্শ্বপ্রতিক্রিয়া
The most common adverse reactions, including laboratory abnormalities, (≥20%) are leukopenia, lymphopenia, fatigue, anemia, neutropenia, increased creatinine, increased alanine aminotransferase, increased glucose,thrombocytopenia, nausea, decreased appetite, musculoskeletal pain, decreased albumin, constipation, dyspnea, decreased sodium, increased aspartate aminotransferase, vomiting, cough, decreased magnesium and diarrhea.
সতর্কতা ও নিষেধাজ্ঞা
সতর্কতা ও সাবধানতা
Myelosuppression: Monitor blood counts prior to each administration. Initiate treatment with Lurbin only if baseline neutrophil count is ≥1,500 cells/mm3 and platelet count is ≥100,000/mm3. Withhold, reduce the dose, or permanently discontinue Lurbin based on severity.Hepatotoxicity: Monitor liver function tests prior to initiating Lurbin, periodically during treatment and as clinically indicated. Withhold, reduce the dose, or permanently discontinue Lurbin based on severity.Extravasation Resulting in Tissue Necrosis: Consider use of a central venous catheter to reduce the risk of extravasation. Monitor patients for signs and symptoms of extravasation during the Lurbin infusion. If extravasation occurs, immediately discontinue the infusion, remove the infusion catheter, and monitor for signs and symptoms of tissue necrosis.Rhabdomyolysis: Monitor creatine phosphokinase (CPK) prior to initiating Lurbin and periodically during treatment as clinically indicated. Withhold, reduce the dose, or permanently discontinue Lurbin based on severity.Embryo-Fetal Toxicity: Can cause fetal harm. Advise females and males of reproductive potential of the potential risk to a fetus and to use an effective method of contraception.