Indications & Uses
Lidocaine 1% is indicated for:
Pharmacology
Lidocaine works mainly by blocking the entry of sodium into nerve cells through channels in the cell membrane known as voltage gated sodium channels. When this sodium entry is blocked, the nerve cannot generate an action potential, so the signal is not carried forward. The site it binds to is thought to lie on the inner, cytoplasmic side of the sodium channel. Because lidocaine attaches more readily to sodium channels that are in their activated state, it blocks nerves that are firing rapidly more quickly than those that are not; this is known as state dependent blockade.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Urethral anaesthesia: For surface anaesthesia of the adult male urethra, 400 mg is required to achieve adequate analgesia. For surface anaesthesia of the adult female urethra, instil 100 to 200 mg in small portions to fill the whole urethra. To obtain adequate anaesthesia, allow several minutes before performing the urological procedure. Lubrication for endotracheal intubation: Apply 100 mg to the surface of the tube just before insertion. Take care to avoid introducing the product into the lumen of the tube. Endoscopy: Instillation of 200 to 400 mg is recommended for adequate analgesia, and a small amount should be applied to the instrument for lubrication. Debilitated patients, elderly patients and children should be given doses in keeping with their age and physical condition. Note: The applicator is sterilised for 5 minutes in boiling water, cooled and attached to the tube. The jelly is instilled slowly as required. The applicator should be detached after each use and the tube kept tightly closed.
Side Effects
Possible side effects include nervousness, dizziness, blurred vision, tremors, drowsiness, convulsions, unconsciousness, respiratory arrest, low blood pressure, myocardial depression, slow heart rate, cardiac arrest and anaphylactic reactions (skin lesions, urticaria, oedema).
Cautions & Contraindications
Warnings & Precautions
Lidocaine absorbs quite well through wounds and mucous membranes, particularly in the airways of the lungs. Z-Lidocaine Jelly should therefore be used carefully where the skin or mucosa is damaged or where there is infection (sepsis) at the site where it will be applied. If the dose or the site of use is likely to produce high blood levels, Z-Lidocaine should be used with caution in people with epilepsy, poor heart function, slow heart rate (bradycardia), impaired liver function or severe shock. This is the same caution that applies to other local anaesthetics. Topical anaesthetics used in the mouth or throat can affect swallowing, which raises the risk of aspiration (food or liquid entering the airways). This matters more in children, who eat often. Numbness of the tongue or the inside of the cheek can also raise the risk of biting injury.
Contraindications
Lidocaine Hydrochloride should not be used in patients with a known history of hypersensitivity to amide-type local anaesthetics.
Pregnancy & Breastfeeding
During pregnancy, there isn't enough reliable evidence to say for certain that lidocaine hydrochloride is safe, though it has been used widely for many years without apparent problems. If treatment is needed during pregnancy, it may be used when no safer option is available. Lidocaine does pass into breast milk, but only in amounts small enough that it generally poses no risk to a nursing child at the doses used for treatment.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Children need a smaller dose of Lidocaine Hydrochloride, adjusted to their age, body weight and physical condition. Elderly patients can be more sensitive to its effects on the body as a whole, so they may also need the dose reduced.
Overdose
Too much Lidocaine Hydrochloride 10% Spray usually shows first as light-headedness, drowsiness and dizziness, and sometimes blurred vision. If the overdose is serious, trembling, seizures or unconsciousness may follow.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Lidocaine Hydrochloride below 25°C in a dry place, away from light.
Drug Interactions
Common questions about Lidocaine 1% 20 mg/ml
What is Lidocaine 1% 20 mg/ml Injection?
Lidocaine 1% 20 mg/ml Injection is a medicine that contains Lidocaine Hydrochloride. It is made by Guardian Healthcare Ltd. It belongs to the Local & Surface anesthesia group of medicines.
What is Lidocaine 1% used for?
Lidocaine 1% is used for: Pain.
What are the side effects of Lidocaine 1%?
Possible side effects include nervousness, dizziness, blurred vision, tremors, drowsiness, convulsions, unconsciousness, respiratory arrest, low blood pressure, myocardial depression, slow heart rate, cardiac arrest and anaphylactic reactions (skin lesions, urticaria, oedema).
Can I take Lidocaine 1% during pregnancy or while breastfeeding?
During pregnancy, there isn't enough reliable evidence to say for certain that lidocaine hydrochloride is safe, though it has been used widely for many years without apparent problems. If treatment is needed during pregnancy, it may be used when no safer option is available. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Lidocaine 1%?
Too much Lidocaine Hydrochloride 10% Spray usually shows first as light-headedness, drowsiness and dizziness, and sometimes blurred vision. If the overdose is serious, trembling, seizures or unconsciousness may follow. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Lidocaine 1%?
Keep Lidocaine Hydrochloride below 25°C in a dry place, away from light.
Can I take other medicines with Lidocaine 1%?
Some medicines can interact with Lidocaine Hydrochloride, for example: Lidocaine. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Lidocaine 1%?
Lidocaine 1% is a prescription (Rx) medicine. Take it as your doctor advises.