Pricing
Prices are indicative MRP and may vary by pharmacy. Trend compares against the last recorded price.
All price changes →Isozine
Rx20 mg + 37.5 mg • Tablet
Indications & Uses
Isozine is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Route of administration: Isozine should be taken in oral route.This tablet should be initiated at a dose of one tablet, three times a day. Dosing should be titrated to a maximum of two tablets three times daily, if tolerated. Although titration of this tablet can be rapid (3-5 days), some patients may experience side effects and may take longer to reach their maximum tolerated dose. The dosage may be decreased to as one-half of this tablet three times a day, if intolerable side effects occur. Efforts should be made to titrate up as soon as side effects subside.Use in children and adolescents: The safety and effectiveness of this combination in children have not been established.
Side Effects
The following adverse reactions have been identified during post-approval use of this tablet- Cardiac Disorders: Palpitations Ear and labyrinth disorders: Tinnitus, vertigo Eye Disorders: Eyelid edema, vision blurred Gastrointestinal Disorders: Abdominal discomfort, constipation General Disorders and Administration Site Conditions: Facial pain, flushing, chest discomfort, chest pain, peripheral edema Musculoskeletal and Connective Tissue Disorders: Pain in extremity, myalgia Nervous Disorders: Dysgeusia, hypoaesthesia, migraine, syncope Renal and Urinary Disorders: Chromaturia, pulmonary renal syndrome Respiratory, Thoracic and Mediastinal Disorders: Dyspnea Reproductive System and Breast Disorders: Erectile dysfunction Skin and Subcutaneous Tissue Disorders: Erythema, hyperhidrosis, pruritus, face swelling
Cautions & Contraindications
Warnings & Precautions
Symptomatic hypotension, particularly with upright posture, may occur with even small doses of Isozine. Hypotension is most likely to occur in patients who have been volume or salt depleted; it should be corrected prior to initiation of Isozine. Hydralazine hydrochloride has been reported to cause a drug-induced systemic lupus erythematosus (SLE) syndrome. Symptoms and signs usually regress when hydralazine hydrochloride is discontinued. Hydralazine hydrochloride can cause tachycardia and hypotension potentially leading to myocardial ischemia and angina, particularly in patients with hypertrophic cardiomyopathy. Hydralazine hydrochloride has been associated with peripheral neuritis, evidenced by paresthesia, numbness and tingling, which may be related to an antipyridoxine effect. Pyridoxine should be added to Isozine therapy if such symptoms develop.
Contraindications
This combination is contraindicated in patients with known hypersensitivity to isosorbide dinitrate or hydralazine hydrochloride or organic nitrates or any other components of this product. It is also contraindicated in patients who are taking PDE-5 inhibitors or soluble guanylate cyclase (sGC) stimulator riociguat.