Indications & Uses
Fosfomax is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage The daily dose of Fosfomycin is determined based on the indication, severity and site of the infection, susceptibility of the pathogen(s) to fosfomycin and the renal function.In children,it is also determined by age and body weight.Adults and adolescents >12 years of age (>40 kg): Fosfomycin is primarily excreted renally unchanged. The general dosage guidelines for adults with estimated creatinine clearance >80 ml/min are as follows: Osteomyelitis: 12-24 gm in 2-3 divided doses Complicated urinary tract infection: 12-16 gm in 3 divided dose Nosocomial lower respiratory tract infection: 12-24 gm in 2-3 divided dose Bacterial meningitis: 16-24 gm in 3-4 divided doses Individual doses must not exceed 8 gm. The high-dose regimen in 3 divided doses should be used in severe infections expected or known to be caused by less susceptible bacteria. There are limited safety data in particular for doses in excess of 16 g/day. Special caution is advised when such doses are prescribed.
Side Effects
The most commonly reported adverse reactions during treatment are gastrointestinal disturbances and injection site reactions. Other important adverse reactions include hypokalaemia and/or hypernatraemia.
Cautions & Contraindications
Warnings & Precautions
To avoid potential development of cross resistance co-administration of Fosfomax with other antibiotics is preferred. A high sodium load associated with the use of fosfomycin may result in decreased levels of potassium in serum or plasma. A low-sodium diet is recommended during treatment. The substitution of potassium may be necessary in some cases. Serum electrolyte levels and water balance must be monitored during therapy. Caution is advised when fosfomycin is used in patients with cardiac insufficiency, hypertension, hyperaldosteronism, hypernatraemia or pulmonary edema. Acute, potentially life-threatening hypersensitivity reactions (anaphylactic shock) may occur in very rare cases. At the first signs (including sweating, nausea, cyanosis), the infusion of fosfomycin must be immediately discontinued.
Contraindications
Hypersensitivity to the active substance, fosfomycin, or to any of the excipients.