ইঙ্গিত ও ব্যবহার
Fosfomax এর জন্য নির্দেশিত:
ডোজ নির্দেশিকা
শুধুমাত্র নির্দেশিকা তথ্য
প্রদর্শিত ডোজগুলি সরকারি উৎসের সাধারণ নির্দেশিকা। ব্যক্তিগতকৃত ডোজের জন্য সর্বদা আপনার ডাক্তার বা ফার্মাসিস্টের পরামর্শ নিন।
প্রাপ্তবয়স্ক:
Dosage The daily dose of Fosfomycin is determined based on the indication, severity and site of the infection, susceptibility of the pathogen(s) to fosfomycin and the renal function.In children,it is also determined by age and body weight.Adults and adolescents >12 years of age (>40 kg): Fosfomycin is primarily excreted renally unchanged. The general dosage guidelines for adults with estimated creatinine clearance >80 ml/min are as follows: Osteomyelitis: 12-24 gm in 2-3 divided doses Complicated urinary tract infection: 12-16 gm in 3 divided dose Nosocomial lower respiratory tract infection: 12-24 gm in 2-3 divided dose Bacterial meningitis: 16-24 gm in 3-4 divided doses Individual doses must not exceed 8 gm. The high-dose regimen in 3 divided doses should be used in severe infections expected or known to be caused by less susceptible bacteria. There are limited safety data in particular for doses in excess of 16 g/day. Special caution is advised when such doses are prescribed.
পার্শ্বপ্রতিক্রিয়া
The most commonly reported adverse reactions during treatment are gastrointestinal disturbances and injection site reactions. Other important adverse reactions include hypokalaemia and/or hypernatraemia.
সতর্কতা ও নিষেধাজ্ঞা
সতর্কতা ও সাবধানতা
To avoid potential development of cross resistance co-administration of Fosfomax with other antibiotics is preferred. A high sodium load associated with the use of fosfomycin may result in decreased levels of potassium in serum or plasma. A low-sodium diet is recommended during treatment. The substitution of potassium may be necessary in some cases. Serum electrolyte levels and water balance must be monitored during therapy. Caution is advised when fosfomycin is used in patients with cardiac insufficiency, hypertension, hyperaldosteronism, hypernatraemia or pulmonary edema. Acute, potentially life-threatening hypersensitivity reactions (anaphylactic shock) may occur in very rare cases. At the first signs (including sweating, nausea, cyanosis), the infusion of fosfomycin must be immediately discontinued.
নিষেধাজ্ঞা
Hypersensitivity to the active substance, fosfomycin, or to any of the excipients.