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These brands contain the same active ingredient (Flunarizine). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Fizi is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Migraine Prophylaxis: The starting dose is 10 mg at night for patients under 65 years of age, and 5 mg daily for patients over 65 years. If depressive, extrapyramidal or other unacceptable symptoms occur during this treatment, it should be stopped. If no significant improvement is seen after 2 months of this initial treatment, the patient should be considered a non-responder and the medicine should be discontinued. Maintenance Treatment: If a patient is responding well and maintenance treatment is needed, the dose should be reduced to 5 days of treatment at the same daily dose, with two consecutive medicine free days each week. Even when prophylactic maintenance treatment is successful and well tolerated, it should be stopped after 6 months and restarted only if the patient relapses. Peripheral Vascular Disease: 10 mg twice daily, up to 30 mg per day if required. Vertigo and Motion Sickness: 10 to 20 mg daily for adults and 5 mg daily for children over 40 kg. Epileptic Seizure: 15 to 20 mg daily for adults and 5 to 10 mg daily for children, as an add on therapy.
Side Effects
Drowsiness and fatigue can occur, along with weight gain or an increased appetite. During long-term treatment with Minium, patients have reported depression, and female patients with a history of depressive illness may be particularly at risk. Extrapyramidal symptoms such as slowed movement, muscle rigidity, restlessness, involuntary facial movements, and tremor have also been reported, with elderly patients seeming particularly at risk. Less commonly reported reactions include heartburn, nausea, stomach pain, insomnia, anxiety, unusual milk production, dry mouth, muscle aches, and skin rash.
Cautions & Contraindications
Warnings & Precautions
Minium can cause drowsiness, and this effect is made worse by drinking alcohol or taking other medicines that slow down the central nervous system. Patients should be careful about driving or doing other tasks that need full mental alertness, since reduced alertness could lead to accidents. Minium is not intended to stop a migraine attack that has already started, so if an attack occurs, the dose should not be increased for this reason. Treatment with Minium can sometimes cause extrapyramidal symptoms, depressive symptoms, or bring out signs of Parkinsonism, particularly in patients who are more prone to this, such as the elderly. For this reason, Minium should be used with care in such patients.
Contraindications
Hypersensitivity to flunarizine is a contraindication, as is a history of depressive illness. Flunarizine should also not be used in patients with pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders.