Pricing
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These brands contain the same active ingredient (Doxophylline). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Doxofyl SR is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Elderly: one 200 mg tablet two or three times daily. Adults: one 400 mg tablet two or three times daily, or as prescribed by the physician. Children above 12 years of age: 10 ml syrup or one 200 mg tablet two or three times daily. Children aged 6 to 12 years: 6 to 9 mg per kg of body weight twice daily. For example, a child weighing 10 kg would take 3 ml (60 mg) twice daily, or as prescribed by the physician. If the required daily dose of Doxophylline is 400 mg, the Doxophylline SR tablet may be taken once daily, or as prescribed by the physician.
Side Effects
Patients taking xanthine-derivative medicines such as doxophylline may experience nausea, vomiting, stomach (epigastric) pain, headache, irritability, insomnia, a fast heartbeat, extra heartbeats (extrasystoles), and rapid breathing. Rarely, high blood sugar or protein in the urine can occur. These symptoms can be an early warning sign of toxicity, and taking too much of the medicine may lead to serious heart rhythm disturbances or seizures. If side effects appear, the treatment may need to be stopped. Once all signs of toxicity have cleared, the physician may, if appropriate, restart treatment at a lower dose.
Cautions & Contraindications
Warnings & Precautions
Numerous factors can slow the liver's clearance of xanthine derivatives, causing the drug's plasma levels to rise. These include age, congestive cardiac decompensation, chronic obstructive pulmonary disease, severe liver disease, concurrent infections, and the simultaneous use of certain drugs such as erythromycin, TAO, lincomycin, clindamycin, allopurinol, cimetidine, influenza vaccine, and propranolol. Where these factors are present, a dose reduction may be necessary. Whenever such factors could affect clearance of xanthine derivatives, monitoring the drug's blood concentration is recommended to keep it within the therapeutic range. Caution is advised when giving this medicine to patients with cardiac disease, hypertension, severe hypoxemia, hyperthyroidism, chronic cor pulmonale, congestive heart failure, liver disease, peptic ulcer, or renal impairment, as well as to elderly patients. Particular caution is needed in congestive heart failure, since drug clearance is considerably slower in these patients, and high blood levels may persist for a long time even after treatment is stopped. There is no risk of addiction or any other form of dependence.
Contraindications
Doxophylline should not be used by anyone who is hypersensitive to it or to related xanthine medicines. It is also unsuitable for patients who have recently had a heart attack, those with low blood pressure, and women who are breastfeeding.