Indications & Uses
Doriject is used to treat the following infections. Complicated intra-abdominal infections caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides caccae, Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Streptococcus intermedius, Streptococcus constellatus, and Peptostreptococcus micros. Complicated urinary tract infections, including pyelonephritis, caused by Escherichia coli (including cases with concurrent bacteremia), Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Acinetobacter baumannii.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage The recommended dosage of Doripenem is 500 mg given every 8 hours by intravenous infusion over one hour in patients over 18 years of age. For complicated intra abdominal infection, the dose is 500 mg every 8 hours for 5 to 14 days, infused over 1 hour. For complicated UTI, including pyelonephritis, the dose is 500 mg every 8 hours for 10 days, infused over 1 hour. Dosage of Doripenem in patients with renal impairment: for CrCl above 50 mL/min, no dosage adjustment is necessary. For CrCl from 30 to 50 mL/min, the dose is 250 mg given intravenously over 1 hour every 8 hours. For CrCl above 10 and below 30 mL/min, the dose is 250 mg given intravenously over 1 hour every 12 hours. Geriatric patients: no dosage adjustment is recommended for elderly patients with normal (for their age) renal function.
Side Effects
Headache, diarrhea, nausea, phlebitis, rash, and vulvomycotic infection.
Cautions & Contraindications
Warnings & Precautions
Serious hypersensitivity reactions, including anaphylaxis and severe skin reactions, have occasionally been fatal in patients taking beta-lactam antibiotics. Before starting Doriject, patients should be carefully asked about any past hypersensitivity reactions to other medicines in this class or to beta-lactam antibiotics generally, and Doriject should be used with caution if such a history exists. If a hypersensitivity reaction occurs during treatment, Doriject should be stopped immediately and appropriate measures taken, since severe acute hypersensitivity (anaphylactic) reactions require immediate emergency care.
Contraindications
Doripenem should not be used in patients with a known serious hypersensitivity to any component of the product, to other drugs in the same class, or in patients who have had an anaphylactic reaction to beta-lactam antibiotics.