Indications & Uses
Doriject is used to treat the following infections. Complicated intra-abdominal infections caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides caccae, Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Streptococcus intermedius, Streptococcus constellatus, and Peptostreptococcus micros. Complicated urinary tract infections, including pyelonephritis, caused by Escherichia coli (including cases with concurrent bacteremia), Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Acinetobacter baumannii.
Pharmacology
Doripenem is a broad-spectrum carbapenem antibiotic. It works against aerobic and anaerobic Gram-positive and Gram-negative bacteria.
Doripenem kills bacteria by stopping them from building their cell walls. It binds to several essential penicillin-binding proteins (PBPs), which blocks cell wall synthesis and leads to the death of the cell. In E. coli and P. aeruginosa, doripenem binds to PBP 2, which helps maintain cell shape, as well as to PBPs 3 and 4.
Absorption: After a single 1-hour intravenous infusion of a 500 mg dose in 24 healthy subjects, the mean plasma concentration of doripenem was 23.0 (6.6) pg/mL. When given intravenously over 1 hour, doripenem's Cmax and AUC rise in a straight line across doses from 500 mg to 1 g. With multiple intravenous infusions of either 500 mg or 1 g every 8 hours for 7 to 10 days, doripenem does not build up in people with normal kidney function.
Distribution: About 8.1% of doripenem binds to plasma proteins, and this does not change with the drug concentration in the plasma. In healthy subjects at steady state, the median volume of distribution (range) is 16.8 L (8.09-55.5 L), which is close to the extracellular fluid volume of 18.2 L.
Metabolism: Doripenem is broken down mainly by dehydropeptidase-I into a ring-opened metabolite, doripenem-M1, which has no antibacterial activity. In pooled human liver microsomes, no metabolism of doripenem could be detected in the lab, so doripenem is not a substrate for hepatic CYP450 enzymes.
Excretion: The kidneys remove most doripenem from the body in its unchanged form. In healthy non-elderly adults, the mean plasma terminal elimination half-life is about 1 hour, and plasma clearance is 15.9 (SD 5.3) L/hour. Mean renal clearance is 10.8 (3.5) L/hour. After a single 500 mg dose in healthy adults, an average of 70% of the dose was recovered in urine as unchanged drug and 15% as the ring-opened metabolite within 48 hours.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage
The recommended dosage of Doripenem is 500 mg given every 8 hours by intravenous infusion over one hour in patients over 18 years of age. For complicated intra abdominal infection, the dose is 500 mg every 8 hours for 5 to 14 days, infused over 1 hour. For complicated UTI, including pyelonephritis, the dose is 500 mg every 8 hours for 10 days, infused over 1 hour.
Dosage of Doripenem in patients with renal impairment: for CrCl above 50 mL/min, no dosage adjustment is necessary. For CrCl from 30 to 50 mL/min, the dose is 250 mg given intravenously over 1 hour every 8 hours. For CrCl above 10 and below 30 mL/min, the dose is 250 mg given intravenously over 1 hour every 12 hours.
Geriatric patients: no dosage adjustment is recommended for elderly patients with normal (for their age) renal function.
Side Effects
Headache, diarrhea, nausea, phlebitis, rash, and vulvomycotic infection.
Cautions & Contraindications
Warnings & Precautions
Serious hypersensitivity reactions, including anaphylaxis and severe skin reactions, have occasionally been fatal in patients taking beta-lactam antibiotics. Before starting Doriject, patients should be carefully asked about any past hypersensitivity reactions to other medicines in this class or to beta-lactam antibiotics generally, and Doriject should be used with caution if such a history exists. If a hypersensitivity reaction occurs during treatment, Doriject should be stopped immediately and appropriate measures taken, since severe acute hypersensitivity (anaphylactic) reactions require immediate emergency care.
Contraindications
Doripenem should not be used in patients with a known serious hypersensitivity to any component of the product, to other drugs in the same class, or in patients who have had an anaphylactic reaction to beta-lactam antibiotics.
Pregnancy & Breastfeeding
Pregnancy Category B. Well-controlled studies in pregnant women have not been done, and because animal studies don't always predict how humans will respond, Doripenem should be used in pregnancy only when clearly necessary. Whether it passes into human breast milk isn't known, but since many drugs do, a nursing mother should use it with caution.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Doripenem away from light and protect it from moisture. Don't keep it in a place warmer than 25°C. Keep it out of reach of children.
Drug Interactions
Common questions about Doripen 500 IV 500 mg
What is Doripen 500 IV 500 mg Injection?
Doripen 500 IV 500 mg Injection is a medicine that contains Doripenem. It is made by Eskayef Pharmaceuticals Ltd., Narayanganj. It belongs to the Other beta-lactam antibiotics group of medicines.
What is Doripen 500 IV used for?
Doriject is used to treat the following infections. Complicated intra-abdominal infections caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides caccae, Bacteroides fragilis, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Streptococcus intermedius, Streptococcus constellatus, and Peptostreptococcus micros.
What are the side effects of Doripen 500 IV?
Headache, diarrhea, nausea, phlebitis, rash, and vulvomycotic infection.
Can I take Doripen 500 IV during pregnancy or while breastfeeding?
Pregnancy Category B. Well-controlled studies in pregnant women have not been done, and because animal studies don't always predict how humans will respond, Doripenem should be used in pregnancy only when clearly necessary. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Doripen 500 IV?
Store Doripenem away from light and protect it from moisture. Don't keep it in a place warmer than 25°C.
Can I take other medicines with Doripen 500 IV?
Some medicines can interact with Doripenem, for example: Valproic Acid. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Doripen 500 IV?
Doripen 500 IV is a prescription (Rx) medicine. Take it as your doctor advises.