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Other brands with the same active ingredient
These brands contain the same active ingredient (Clonazepam). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Depanil is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Oral, adults: For seizure disorders, the starting dose should not exceed 1.5 mg a day, split into three doses. The dose may be increased by 0.5 to 1 mg every 3 days until seizures are well controlled or side effects prevent any further increase. The maintenance dose must be tailored to each patient based on response, and the maximum recommended daily dose is 20 mg. For panic disorder, the starting dose is 0.25 mg given in two divided doses, which may be raised to a target of 1 mg a day for most patients after 3 days. Pediatric patients: To minimize drowsiness, infants and children up to 10 years of age or 30 kg of body weight should start with 0.01 to 0.03 mg/kg a day, not exceeding 0.05 mg/kg a day, given in two or three divided doses. Injection: For infants and children, half a vial (0.5 mg) is given by slow IV injection or IV infusion. For adults, 1 vial (1 mg) is given by slow IV injection or IV infusion; this dose can be repeated as needed, and 1 to 4 mg is usually enough to reverse status epilepticus. In adults, the injection rate must not exceed 0.25 to 0.5 mg per minute (0.5 to 1.0 ml of the prepared solution), and a total dose of 10 mg should not be exceeded.
Side Effects
Xyclon's most common side effects stem from CNS (central nervous system) depression. In seizure treatment, drowsiness has occurred in about 50% of patients and unsteady movement (ataxia) in about 30%; these may lessen over time. Behavior problems have been noted in about 25% of patients. Abnormal eye movements, loss of voice, coma, tremor, dizziness, confusion, depression, memory loss, hallucinations, hysteria, increased libido, insomnia, psychosis, and heart palpitations may also occur.
Cautions & Contraindications
Warnings & Precautions
When several different types of seizures are present at the same time, Xyclon may increase how often generalized tonic-clonic seizures occur, or trigger them for the first time. If this happens, other anticonvulsants may need to be added, or their doses increased. Taking Xyclon together with valproic acid may bring on absence status.
Contraindications
Contraindicated in anyone with a known hypersensitivity to benzodiazepines, and in anyone with significant liver disease, whether this shows up clinically or only on liver function tests. Patients with open angle glaucoma can take it if they're already on suitable treatment for that; those with acute narrow angle glaucoma should not take it at all.