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Other brands with the same active ingredient
These brands contain the same active ingredient (Efavirenz). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Adiva in combination with other antiretroviral agents is indicated for the treatment of HIV-1 infection. This indication is based on analyses of plasma HIV- RNA levels and CD4 cell counts in controlled studies of up to 24 weeks in duration. At present, there are no results from controlled trials evaluating long term suppression of HIVRNA with Adiva.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage in Adults: The recommended dose of Efavirenz is 600 mg taken by mouth once daily, combined with a protease inhibitor and/or nucleoside analogue reverse transcriptase inhibitors (NRTIs). Dosage in Pediatric Patients: For children 3 years of age or older weighing between 10 and 40 kg, the recommended dose of Efavirenz depends on body weight. Children weighing 10 to less than 15 kg should receive 200 mg once daily. Those weighing 15 to less than 20 kg should receive 250 mg once daily. Those weighing 20 to less than 25 kg should receive 300 mg once daily. Those weighing 25 to less than 32.5 kg should receive 350 mg once daily. Those weighing 32.5 to less than 40 kg should receive 400 mg once daily. Children weighing 40 kg or more, as well as those weighing more than 40 kg, should receive the same dose used in adults, which is 600 mg once daily.
Side Effects
Efavirenz can cause skin rashes and a range of psychiatric or CNS (central nervous system) effects, including amnesia, agitation, confusion, dizziness, vertigo, headache, a feeling of euphoria, insomnia or excessive sleepiness, difficulty concentrating, abnormal thinking or dreaming, and depersonalisation, as well as convulsions and hallucinations. Other reported effects include nausea, vomiting, diarrhoea, pancreatitis, fatigue, liver failure, and photoallergic dermatitis (a skin reaction triggered by light). It has also been linked to autoimmune disorders, such as Graves' disease, polymyositis, and Guillain-Barre syndrome, as well as osteonecrosis (bone tissue death). The medicine may also cause accumulation or redistribution of body fat (lipodystrophy), which can appear as central obesity, wasting of fat from the face and limbs, a buffalo hump, breast enlargement, or a cushingoid (steroid-like) appearance. Metabolic abnormalities may also occur, including high cholesterol, high blood sugar, high triglycerides, elevated lactate levels, and insulin resistance.
Cautions & Contraindications
Warnings & Precautions
Use with caution in patients with a history of seizures, psychiatric disorders, or acute porphyria, and in those taking voriconazole or rifampicin (weight ≥50 kg). Stop if severe rash or fever occurs. Use with caution in moderate hepatic and severe renal impairment. Caution in children and pregnancy.
Contraindications
Do not use if hypersensitive to it, in severe liver impairment, or while breastfeeding. Avoid combining with terfenadine, astemizole, cisapride, midazolam, triazolam, pimozide, bepridil, ergot alkaloids, or St John's wort.